Open Access DOI:10.23937/2377-4630/1410083

Dexmedetomidine Infusion an Effective Intra-Operative Medication for Patients Undergoing Laparoscopic Cholecystectomy

Summaira Jan, Tawheed Ahmad and Saima Rashid

Article Type: Research Article | First Published: December 20, 2018

Laparoscopic surgeries involves creation of pneumo-peritoneum with insufflation of gas usually CO2 thereby increasing intra-abdominal pressure. The Intra-abdominal pressure above 10 mmHg causes adverse hemodynamic changes. Various agents have been used to attenuate these adverse effects. Dexmedetomidine alpha-2 agonist has sedative, sympatholytic, analgesic and anxiolytic properties and used in laparoscopic cholecystectomies for attenuation of adverse hemodynamic changes and to maintain hemodyna...

 Open Access DOI:10.23937/iaoms-2017/1710019

Single Surgery Mandibular Resection, Reconstruction and Bone Graft via Intra-Oral Approach: A Novel Technique

Jameel Desai and Coelette Smit

Article Type: Case Report | First Published: December 20, 2018

Challenges in mandibular bony defect reconstruction still exist. The use of compacted autogenous particulate corticocancellous bone, together with a human humerus allograft presents an exciting opportunity to simplify the reconstruction of such defects. This is especially the case when the surgery may be done in one stage via an intra-oral approach. We present a case where all of the above have been incorporated for the reconstruction of the mandible....

 Open Access DOI:10.23937/iaoms-2017/1710018

The Use of Allogenic Human Demineralised Humerus as a Mandibular Reconstructive Conduit: A Novel Technique

Jameel Desai and Coelette Smit

Article Type: Brief Report | First Published: December 20, 2018

Reconstructing mandibular defects after trauma or ablative surgery is reliably done with compressed autogenous cortical and cancellous particulate bone. We present the use of a demineralised allogenic humerus shaft as a conduit for the autogenous particulate bone. This technique simplifies surgery, is less morbid for the patient, the graft also resembles the remaining native mandible and reduces overall treatment cost for such patients....

 Open Access DOI:10.23937/ijrdd-2017/1710005

Evaluation and Valuation of the Price of Expensive Medicinal Products: Application of the Discounted Cash Flow to Orphan Drugs

Mark Nuijten, Hans Joerg Fugel and Jan Vis

Article Type: Research Article | First Published: December 19, 2018

The current policy for price negotiations on high prices of orphan drugs in Europe is neither a transparent nor a structural solution for reimbursement decisions for orphan drugs. In a previous paper, we proposed the Discounted Cash Flow model as an alternative assessment methodology for the price of innovative drugs including the investor's perspective. The objective of this current paper was to apply this concept to orphan drugs in The Netherlands, where pharmaceutical companies were recently ...

 Open Access DOI:10.23937/2469-5742/1510050

Penile Prosthesis Surgery in Italy: Personal Experiences, Complications and Considerations after 552 Cases

Diego Pozza, Mariangela Pozza and Carlotta Pozza

Article Type: Review Article | First Published: December 19, 2018

The Implant of Penile Prostheses (Silicone, Malleable, Inflatable) represents an efficient solution for patients affected by Erectile Dysfunction (ED) and penetrating incapacity who do not respond to the other treatment modalities (PDE5i, PGE1, Vacuum Systems). Patients with penile prostheses regain the spontaneity of intercourses without having to assume drugs, to introduce mechanically medical substances or to activate complex mechanisms. Just like the whole field of prosthetic surgery, introd...

 Open Access DOI:10.23937/2378-3656/1410248

Progressive Cervical Myelopathy Caused by Bilateral Spontaneous High-Flow Vertebro-Vertebral Arteriovenous Fistulas Associated with Fibromuscular Dysplasia Successfully Treated by Endovascular V2 Segments Sacrifice Using Fibered Coils: A Case Report

Prasert Iampreechakul, Anusak Liengudom, Korrapakc Wangtanaphat, Punjama Lertbutsayanukul, Yodkhwan Wattanasen and Somkiet Siriwimonmas

Article Type: Case Report | First Published: December 19, 2018

The authors reported an extremely rare case of bilateral spontaneous vertebro-vertebral arteriovenous fistulas (VVAVFs) associated with fibromuscular dysplasia (FMD). A 53-year-old hypertensive woman has been placed on antiplatelet drug following diagnosis of supratentorial ischemic stroke for 2 years. Few months before hospitalization, she developed bilateral audible bruits and progressive spastic quadriparesis. Magnetic resonance imaging (MRI) of the cervical spine showed bilateral dilated epi...

 Open Access DOI:10.23937/iaphcm-2017/1710015

Paradigm Shift in Healthcare through Technology and Patient-Centeredness

Abdulrahman Mohammed Al Muammar, Zakiuddin Ahmed and Abdullah M. Aldahmash

Article Type: Review Article | First Published: December 15, 2018

Amidst the background of numerous challenges confronting the healthcare sector (such as rising costs, chronic disease upsurge and issues related to patient safety), this narrative review aims to shed light on the opportunities provided by patient-centered care and technology use as a means to improve and reshape the healthcare sector. The evolution of technology use in healthcare from telemedicine to the present era of connected health is highlighted and discussed as a pertinent emerging model t...

 Open Access DOI:10.23937/iacvd-2017/1710013

Clinical Significance and Applications of D-Ribose in Cardiovascular Disease

Melike Bayram, David Perkowski, JA St Cyr and William T Abraham

Article Type: Review Article | First Published: December 15, 2018

Cardiovascular disease is the leading cause of deaths worldwide. Myocardial ischemia, a common etiological factor in cardiovascular disease, lowers cellular high-energy phosphate levels, i.e. adenosine triphosphate (ATP), with an accompanying impairment in myocardial function. Furthermore, scientists have argued for the importance of ATP levels in supporting both systolic and diastolic function in heart failure. The magnitude of ischemic heart disease and congestive heart failure is generally we...

 Open Access DOI:10.23937/2474-1353/1510086

Magnitude of Home Delivery and Associated Factors among Antenatal Care Booked Mothers in Delanta District, South Wollo Zone, North East Ethiopia: A Cross-Sectional Study, March 2018

Tilahun Wodaynew, Bekana Fekecha and Biru Abdisa

Article Type: Original Article | First Published: December 13, 2018

Home delivery is childbirth in a non-clinical setting that takes place in residence than in health institution. Globally, every day more than 800 women died due to complications during pregnancy or childbirth. In Ethiopia, few are known about the factors that affect women's place of delivery after utilization of antenatal care service. Therefore, the aim of this study was to assess the magnitude of home delivery and associated factors among antenatal care booked mothers in Delanta district, Nort...

 Open Access DOI:10.23937/2474-1353/1510085

Oncofertility: An Area of Reproductive Medicine Capable to Protect the Fertility of Cancer Patients

Ana Flavia Bezerra da Silva, Thais Perez Leal, Amanda Torres Panta and Deborah de Melo Magalhaes Padilha

Article Type: Review Article | First Published: December 13, 2018

Cancer, also called malignant neoplasm, is a disorder which can be manifested in almost anywhere in the body as a result of errors in the cell cycle control machinery, resulting in the formation of tumors. Although the pursuit of a cure is still a top priority for cancer research, the concern about the side effects that the treatment of the disease can produce is an important factor that must be taken into account. One undesirable consequence is infertility, since patients are subordinate to the...