Open Access DOI:10.23937/IACVD-2017/1710015
An Unusual Thrombosis Mimicking Cor Triatriatum Dextra
Murat Surucu, MD, Hazım Alper Gursu and I Ilker Cetin
Article Type: CASE REPORT | First Published: February 25, 2019
Central venous catheters are commonly used in clinical practice. Right atrial thrombosis is a relatively common complication associated with indwelling catheter use. Thrombosis can be in different locations and forms within vascular and intracardiac structures. Echocardiographic images may mimic some anatomic and pathologic variants. We describe a case of a two-months-old girl with a thrombus which cor triatriatum dexter-like appearance in the right atrium due to the central venous catheter....
Open Access DOI:10.23937/IACVD-2017/1710014
Effects of Morning versus Evening Administration of Perindopril on the Circadian Control of Blood Pressure in Cameroonian Type 2 Diabetes Individuals: A Crossover Randomized Trial
Liliane Mfeukeu Kuate, Helene Ornella Bongha Ondoa, Jean-Claude Katte, Aurel Tiakouang Tankeu, Mireille Claudia Abeng Bokam, Andre Michel Bimbai, Ahmadou Musa Jingi, Chris Nadege Nganou-Gnindjio, Mesmin Yefou Dehayem, Francois Folefack Kaze, Jean Claude Mbanya, Andre Pascal Kengne and Eugene Sobngwi
Article Type: RESEARCH ARTICLE | First Published: February 25, 2019
Renin-angiotensin system antagonists are the mainstays of blood pressure (BP) lowering strategies in people with diabetes. Perindopril a long half-life Angiotensin Converting Enzyme (ACE) inhibitor offers the advantage of a single daily dose, usually empirically taken in the morning. We therefore aimed to assess the influence of time of administration on the effect of Perindopril on circadian BP in type 2 diabetes (T2D) individuals with previously untreated stage 1 hypertension. Twenty T2D patie...
Open Access DOI:10.23937/2469-5726/1510070
Severe MTX Toxicity in Rheumatic Diseases - Analysis of 22 Cases
Bergner R, Wadsack D and Loffler C
Article Type: REVIEW ARTICLE | First Published: Febrayry 25, 2019
Severe MTX (methotrexate) toxicity due to low dose MTX used in rheumatic diseases is rare but linked with a high mortality ranging from 13 to 44%. We analyzed 22 cases with a minimum toxicity of CTC (common toxicity criteria) grade 2, that were admitted to our hospital. We retrospectively analyzed epidemiological data, the weekly MTX dosage, renal function before and at the beginning of the adverse event, co-medication with influence on MTX toxicity or on renal function and potential other co-fa...
Open Access DOI:10.23937/2378-3672/1410035
Cancer Immunotherapy Therapeutic Manipulation of the CD8-HLA Class I Interaction: Potential and Challenges
P Savage
Article Type: REVIEW ARTICLE | First Published: February 23, 2019
The interaction between CD8 and HLA class I is largely monomorphic and of low affinity. Previous HLA mutation studies have indicated that manipulation of the affinity of this interaction can have dramatic biological effects. Reductions in CD8-HLA class I affinity can lead to inhibition of T cell mediated target cell killing, whilst modest affinity increases lead to enhanced target cell killing whilst retaining antigenic specificity. Here it is shown that target cells bearing a high affinity chim...
Open Access DOI:10.23937/2378-3001/1410080
Charcot-Marie-Tooth Disease Type 1A and Inflammatory-Demyelinating Lesions in the Central Nervous System
Daniel A Garcia-Estevez, Carmen Cid-Rodriguez and Guillermo Ozaita-Arteche
Article Type: CASE REPORT | First Published: February 23, 2019
Charcot-Marie-Tooth disease (CMT) is a hereditary sensorimotor polyneuropathy which is occasionally associated with demyelinating lesions in the central nervous system, although it remains unclear whether this finding is coincidental or whether the two processes share a common pathogenic mechanism. A male patient with sensorimotor polyneuropathy presented with symptoms consistent with cauda equina syndrome at age 47 in relation to an inflammatory lesion in the conus medullaris. Six years later, ...
Open Access DOI:10.23937/2469-5769/1510050
Looking toward the Future: An Inquiry into the Acceptance of a Hypothetical Laboratory-based Screening Test for Autism Spectrum Disorder
Jane M DeLuca, PhD, RN, CPNP-PC, Sara M Sarasua, PhD, MSPH and Luigi Boccuto, MD
Article Type: ORIGINAL RESEARCH | First Published: February 23, 2019
Currently, a clinical diagnosis of autism spectrum disorder (ASD) is determined by behavioral/ observational evaluations performed on children ages 2-5 years. Research suggests that laboratory-based tests for screening or diagnosis of ASD may be available in the future. In this study, we examined attitudes towards the acceptance of a hypothetical laboratory-based screening test for children for ASD. For this study, a survey was developed to capture opinions about a hypothetical ASD laboratory te...
Open Access DOI:10.23937/2572-3286.1510042
Hyper-Acute Presentation of Access Based Cardiac Disease
Mohamed A Sheta, MD, Axita Patel, OMS and John R Ross, MD
Article Type: CASE REPORT | First Published: February 23, 2019
Fifty years after the creation of the first arteriovenous access, little is known about the deleterious cardiac effects of this pathological circuit. Understanding the pathophysiology of Access Based Cardiac Disease (ABCD) is critical, given the fact that cardiac abnormalities are the leading cause of morbidity and mortality in end stage kidney disease patients on dialysis. However, this has been a challenge, as many of hemodialysis patients have preexisting cardiac disease, they invariably have...
Open Access DOI:10.23937/2377-9004/1410140
Hyperextension of the Fetal Neck
CR Elizalde, P Dieste, J Fernandez, V Fernadnez and C Zulueta-Santos
Article Type: CASE REPORT | First Published: February 22, 2019
The purpose of this study was to review the current challenges that the diagnosis and clinical management of hyperextension of the fetal neck represent and to describe the clinical significance and differential diagnosis of this entity, detected by ultrasound prior to the onset of labour. A case of hyperextension the fetal neck is presented. The key points in the diagnosis and management of fetuses with these sonographic finding are reviewed. Hyperextension of the fetal neck is a sonographic fin...
Open Access DOI:10.23937/IAOS-2017/1710005
Age and Gender-Related Collagen Alterations in the Transverse Carpal Ligament of Carpal Tunnel Syndrome
Srinath Kamineni, Satya Alluri, Hamza Ashfaq and Yoshida Ruriko
Article Type: RESEARCH ARTICLE | First Published: February 21, 2019
The aim of our study was to examine both age and gender-related alterations in collagen expression of the transverse carpal ligament (TCL) in patients with idiopathic carpal tunnel syndrome (CTS). Resected TCLs were collected from 10 patients undergoing open carpal tunnel decompression. These were randomly divided equally into two groups of five patients, with equal numbers of men (average age 49.6) and women (average age 57.4). Histological staining [Hematoxylin & eosin and Picrosirius red (PSR...