Open Access DOI:10.23937/2474-3631/1510040

Understanding Addiction: Insights from Research and Medicine

Kieran Poland, MbChBMRes and Patrick Davies, BMedSci BMB MRCPCH

Article Type: Research Article | Publication Updated: 2024/06/06

Addiction, a multifaceted neurobiological disorder characterized by compulsive substance use despite negative consequences, poses significant challenges to public health worldwide. This paper presents a comprehensive examination of addiction research and medicine, delving into the intricate neurobiological mechanisms, current treatment modalities, and future prospects for intervention. By synthesizing existing knowledge and exploring emerging avenues of inquiry, this review aims to contribute to...

 Open Access DOI:10.23937/2474-3631/1510039

Inhibitory Potential of Struchium sparganophora Phytochemicals on Cyclooxygenases and Their Health Implications on Inflammations and Pains

Ololade Zacchaeus S, Oyebanji Olawumi T, Onifade Olayinka F, Olaniran Anikeola C, Idowu Oluwatope O, Quadri-Oloye Mariam T and Tommy Bessie E

Article Type: Research Article | Publication Updated: 2024/06/06

The inhibition of cyclooxygenases provides analgesic effect to relief inflammation and pain. The in silico study herein aimed to predict and elucidate the inhibitory potential of S. Sparganophora phytochemicals on the enzymes. An integrated molecular modeling approach which includes molecular docking, MMGBA, and pharmacokinetic profiling was employed to identify potential inhibitors of COX-1 and COX-2 from the characterized phytochemicals of S. Sparganophora....

 Open Access DOI:10.23937/2469-5696/1410096

The Association between Iron Deficiency Anaemia and Leukopenia, and the Effect of Intravenous Iron Correction on Leukopenia

Joanna Kae Ling Wong, Charlotte Chu-Hong Zheng, Samuel McGowan-Smyth and Chiraag Talati

Article Type: Original Article | Publication Updated: 2024/06/06

Iron deficiency anaemia (IDA) has been observed concomitantly with unexplained leukopenia. However, this association is limited in literature. We investigated the association between IDA and leukopenia and explored iron therapy as a novel approach to improving immune function in patients with leukopenia....

 Open Access DOI:10.23937/2378-3656/1410451

Diffuse Large B Cell Lymphoma: A Case Report with a Review on the Diverse Immunohistochemical Characteristics and Current Therapeutic Challenges

Ayushi Jain1, Arushi Tomar1, Shalini Gupta, Veerendra Verma and Sameer Gupta

Article Type: Case Report & Review of Literature | Publication Updated: 2024/05/31

An aggressive non-Hodgkin lymphoma, with subtype of diffuse large B-cell lymphoma (DLBCL) is most frequent lymphoid malignancy in this category, especially in the tonsillar region. However, despite the numerous clinical series available, there is a lack of clear clinicopathological and immunohistochemical characteristics available due to diverse patterns seen in this tumour. So, more directed approach is needed for the treatment which is presented with the case review in the following study....

 Open Access DOI:10.23937/2377-3634/1410184

Prevalence of Major Comorbidities and Associated Factors among Adult Diabetic Patients Attending Diabetic Follow up Clinic at Selected Public Hospitals of Addis Ababa, Ethiopia

Haleluya Girma, Kabtiymer Shiferaw and Mesfin Aklilu

Article Type: Research Article | Publication Updated: 2024/06/05

Data was collected from April 28 to May 29, 2023. 417 study participants from 4 public hospitals were selected with simple random sampling technique. Data was collected by using structured and pretested questionnaire, medical record was used in order to obtain relevant information’s and measurement was done to obtain BMI. Data was analyzed using SPSS version 25. Bivariable and Multivariable binary logistic regression analysis were done to determine the association between the outcome variable ...

 Open Access DOI:10.23937/2643-4512/1710098

Knowledge, Attitudes and Practices of Obstetric Care Providers Regarding Pre-Eclampsia in the Yaoundé IV District

Wilfried Loïc TATSIPIE, Junie Annick METOGO NTSAMA, Amandine BAYOKOLAK, Gwenaelle DIOH NYAMBI, Madye NGO DINGOM, Pascal MPONO, Claude Cyrille NOA NDOUA, Julius DOHBIT SAMA and Pascal FOUMANE

Article Type: Original Article | Publication Updated: 2024/06/05

Pre-eclampsia is a pregnancy-related condition which complicates 7 to 9% of all pregnancies and is a major risk factor, exposing both mother and foetus to multiple complications, some of which may be life-threatening. It is the third leading cause of maternal mortality in Africa. In Cameroon, the prevention and management of pre-eclampsia remains sub-optimal, particularly in peripheral health facilities, which are very busy....

 Open Access DOI:10.23937/2643-4571/1710059

Researching Fabry Disease in Autosomal Dominant Polycystic Kidney Disease Patients

Yakup Özgüngör and Abdulmecit Yildiz

Article Type: Original Article | Publication Updated: 2024/06/03

This study aims to determine the frequency of Fabry disease misdiagnosis with autosomal dominant polycystic kidney disease (ADPKD). Additionally, the study aims to characterize the clinical and biochemical features of Fabry disease patients initially diagnosed with ADPKD....

 Open Access DOI:10.23937/2474-3674/1510161

Serratus Anterior Plane Block for Multiple Rib Fractures- A Novel Pain Management Technique

Aaron Dsouza and Divya Vincent

Article Type: Original Article | Publication Updated: 2024/05/31

Rib fractures are mostly traumatic. Commonly seen in patients suffering from multiple injuries due to road traffic accidents or fall from height, conventional treatment is with intravenous/oral analgesics or opioid patches. The innervation of the ribs passes through the Serratus Anterior Plane and hence we aim to administer anaesthetic in this plane to achieve reliable and quality pain relief....

 Open Access DOI:10.23937/2469-5807/1510152

Adult Hirschsprung's Disease- A Case Report

Meena Pangarkar, Anuja Nasare and Radhika Pagey

Article Type: Case Report | Publication Updated: 2024/06/03

Adult Hirschsprung's disease (HD) is a rare motor disorder of the gut that is frequently misdiagnosed as refractory constipation and treated with laxatives. The primary pathology of adult HD is the total absence of intramural ganglion cells of the submucosal and myenteric neural plexuses in the affected segment of the bowel. 94% of HD cases are diagnosed before the patient reaches 5-years of age, however, on rare occasion, mild cases of HD may go undiagnosed until they reach adulthood and presen...

 Open Access DOI:10.23937/2643-4512/1710097

Educational Intervention to Limit Occupational Tuberculosis among Healthcare Workers in Kaduna State, Northwestern Nigeria

Chiroma Laminu, AdesolaZaidat Musa and Tubosun Alex Olowolafe

Article Type: Review Article | Publication Updated: 2024/06/03

Tuberculosis (TB) has been documented as one of the occupational diseases affecting general healthcare workers globally, caused by mycobacterium tuberculosis (MTB) affecting the lungs (Pulmonary TB) and other part of the body (Extra pulmonary TB). The study provides educational interventions that limit occupational transmission of tuberculosis among healthcare workers in Kaduna State, Nigeria....