Open Access DOI:10.23937/2643-4539/1710010
A Review on Alzheimer Disease
Deeksha Kaloni and Abhishek Negi
Article Type: Review Article | First Published: September 18, 2019
Alzheimer is one of the most common causes of dementia that influence nerve cells in various parts of the brain. Pathologically it is caused because of intracellular neurofibrillary tangles and extracellular amyloidal protein and results in the deposition of plaques which obstruct the communication between the nerve cells resulting in this neurodegenerative disease. The genetic risk factor found to be associated with this disease is mutation in APP, PSEN1 and PSEN2 genes. Also, the diet and nutr...
Open Access DOI:10.23937/2643-3885/1710035
A Novel Approach to Post-Traumatic Foot and Ankle Pains using Percutaneous Ultrasound Guided Cryoneurolysis: A Case Report
David H Sherwood, DO, Jason-Flor V Sisante, PhD and Neil A Segal, MD, MS
Article Type: Case Report | First Published: September 20, 2019
Cryoneurolysis is a minimally invasive, low side effect profile, evidence-supported intervention currently with FDA approval to produce lesions in peripheral nervous tissue, including for relief of pain associated with knee osteoarthritis. The mechanism of action on a peripheral nerve is temporary axonal signal disruption via Wallerian degeneration. While the axon and myelin sheath degenerate, the endoneurium, perineurium and epineurium are unaffected. Schwann cells and macrophages clear debris,...
Open Access DOI:10.23937/2643-3885/1710034
Extreme Thrombocytosis Resulting from Minimally Invasive Foot Surgery with Forefoot Necrosis: A Rare Case Report
Cuervas-Mons Manuel, Alvarez Baena Lucia, Garcia Ruano Angela and Arnal Burro Javier
Article Type: Case Report | First Published: September 19, 2019
Essential thrombocythemia is a chronic myeloproliferative syndrome characterised by excessive proliferation of platelets and megakaryocytes, with a relatively favourable course. We present a case of extreme thrombocytosis resulting from minimally invasive foot surgery with forefoot necrosis. A 72-year-old female patient presented with hallux valgus and metatarsalgia. A platelet count of 560,000/ µL was detected as an unexpected finding. Minimally invasive surgery was performed, and in the first...
Open Access DOI:10.23937/2377-3634/1410111
More Than Just 1200 Foot Care Nurses in America are Needed for 30.3 Million People Who Have Diabetes
Jacqueline E Sharpe, PhD, RN, CHES
Article Type: Commentary | First Published: September 23, 2019
There is an outstanding group of registered nurses who specialized in the care of wounds and working with DFUs. Since there are only about 1200 of them in the US and 30.3 million people who have diabetes, these nurses need some help and that help can come from the community. Looking at the increasing number of people with diabetes and their need to know preventive care information, there is no time better than this for community organizing and community building for health and wellness. One does...
Open Access DOI:10.23937/2377-3634/1410110
Is it Time to Review the Role of Continuous Glucose Monitoring Systems in Diabetes Management?
Le Minh Quang, MSc, MD
Article Type: Review Article | First Published: September 19, 2019
Hemoglobin A1C (HbA1c) and self-monitoring of blood glucose (SMBG) are widely used as standardized measurements in diabetes management. HbA1c is a measure of the mean blood glucose level over a period of 8-12 weeks. This index is easy to measure, relatively inexpensive and internationally standardized. HbA1c helps to predict the complications, particularly microvascular complications in patients with diabetes. However, because HbA1c represents only an average measure of glucose levels, it does n...
Open Access DOI:10.23937/2378-3419/1410124
TCM Combined Chemoradiotherapy in the Treatment of LimitedStage Small Cell Lung Cancer: Current Status and Perspectives
Shulin He, Rui Liu, Qiujun Guo, Huamin Wei, Yanjiu Bao, Xinyao Xu, Shuntai Chen, Honggang Zheng and Baojin Hu
Article Type: Review Article | First Published: September 21, 2019
About 13% of lung cancer cases are of the small cell subtype, but this variant is highly aggressive, and approximately 40% of patients with small cell lung cancer will have limited-stage disease, which is potentially curable with the combination of chemotherapy and radiation therapy. The standard therapy for limited-stage small cell lung cancer is concurrent chemoradiotherapy, and the 5-year survival rate observed in clinical trials is approximately 25%. For patients who obtain a near complete o...
Open Access DOI:10.23937/2474-3674/1510092
Isoproterenol and Lidocaine for Recurrent Torsades de Pointes in a 32-Year-Old Pregnant Woman
Breyanna Reachi, PharmD, Jenna Negrelli, PharmD, Abby Hickman, PharmD, MBA, BCCCP, Sarah Beesley, MD and Jeffrey Osborn, MD
Article Type: Case Report | First Published: September 19, 2019
A 15-week pregnant 32-year-old female was admitted to an outside hospital for alcohol withdrawal and developed multiple episodes of ventricular tachycardia (VT) and TdP resulting in her prompt transfer to our hospital for escalation of care. On arrival she was awake, alert, and hemodynamically stable but quickly began experiencing recurrent episodes of TdP that developed into pulseless VT despite defibrillation, magnesium and calcium administration, and chest compressions. We initiated lidocaine...