Open Access DOI:10.23937/2469-5793/1510121
Evidence-Based Health Policy Making: A Roadmap for Filling the Research and Decision-Making Gap
Nader Aghakhani, Kazhal Mobaraki and Jamal Ahmadzadeh
Article Type: Letter to the Editor | First Published: June 18, 2020
The ultimate aim of a health care system is progression of community health in an equal manner and various factors can be contributed in achieving it. Many health policy makers or managers try to produce evidences to be used in the health care system for this goal and they need many types of scientific documents to make well-informed decisions. For this reason, the importance of evidence-based health policy making as a complicated task that affects many various individual and organizational acti...
Open Access DOI:10.23937/2469-5750/1510086
Pemphigoid Gestationis: A Third-Trimester Multigravida with a Severe Disease
López Gutiérrez Andrea Fernanda, Gonzalez Saldaña Sandra, Mendez Flores Raul Gerardo, Gomez Cevallos Teresa Aranzazu and Salas Nuñez Lupita Nazaret
Article Type: Case Report | First Published: June 13, 2020
Pemphigoid gestationis is a rare autoimmune vesiculobullous disease that occurs during pregnancy or postpartum. It is caused by circulating IgG autoantibodies that target the extracellular non-collagenous domain of the hemidesmosomal protein BP180. Urticarial papules and plaques with posterior development of tense vesicles and bullae with an erythematous background are the hallmark of the disease. It affects both primigravidas and multigravidas and can occur in any trimester or postpartum but pr...
Open Access DOI:10.23937/2469-584X/1510074
COVID-19 and Liver Injury: Hepatology Perspectives
Natassia Vianna Bocchese, Noele Gurgel Dávila, Maria Beatriz Maia Rodrigues, Irami Araújo- Neto, Mariana de Oliveira Costa, Diniz de Meiroz Grillo Barbalho, Amália Cinthia Meneses Rêgo and Irami Araújo-Filho
Article Type: Review Article | First Published: June 27, 2020
SARS-CoV-2, a severe acute respiratory syndrome caused by Coronavirus 2, discovered in 2019 in China, is responsible for the current pandemic declared by the WHO since March 2020. The clinical syndrome caused by Covid-19 has a broad spectrum of severity. The most common clinical manifestations are fever, dry cough, dyspnea, fatigue, and anosmia. The virus binds to receptors for angiotensin-converting enzyme 2 (ECA2) and serine protease TMPRSS2 for protein S initiation, which are expressed not on...
Open Access DOI:10.23937/2469-567X/1510065
A Review on Remdesivir: An Alternative Antiviral Drug to Fight against COVID-19
Nimesh Singh, Bharat Suthar, Abhay Mehta, Sandeep Shukla and Archna Pandey
Article Type: Review Article | First Published: June 20, 2020
Coronavirus contamination that was found in mid-2019 has just hampered the world’s motivation up until now. The quantity of irresistible cases has become worldwide to 35 lakhs thus the episode has been portrayed as a pandemic by the planet’s wellbeing association, yet there have not been any “particular medications” or antibodies accessible to date. Applicable reports have distinguished a novel coronavirus with 80% homology. So there are not many signs accessible when different nations a...
Open Access DOI:10.23937/2469-567X/1510064
Vitamin D: A Review and Proposed Evidence for Treatment or Prevention in COVID-19
Nimesh Singh, Bharat Suthar, Abhay Mehta, Sandeep Shukla and Archna Pandey
Article Type: Review Article | First Published: June 20, 2020
WHO declared COVID-19 a worldwide pandemic. The ambitions of this paper are to assess if there is any affiliation between mean levels of diet D in various countries and cases respectively mortality because of COVID-19. Low vitamin D repute in winter allows viral epidemics. During iciness, those who do not take Vitamin D supplements are possibly to have low serum 25-hydroxyvitamin D [25(OH)D] (25-hydroxyvitamin D) concentrations. Vitamin D can reduce the chance of viral epidemics and pandemics in...
Open Access DOI:10.23937/2643-461X/1710033
Malaria Control Efforts in the Era of COVID-19: A Call to Remain Vigilant in Endemic Areas
Eliningaya J Kweka
Article Type: Commentary | First Published: June 19, 2020
Success in controlling malaria has been reported across the world mainly through the use of long-lasting insecticidal nets, indoor residual spray, and appropriate diagnosis and treatment. However, in the era of COVID-19, more attention has been shifted to cases and mortality caused by the SARS-CoV-2 virus, which are jeopardizing the continuity of efforts attained so far in malaria control. This commentary proposes alternatives to be adopted during the COVID-19 pandemic to maintain the attained m...
Open Access DOI:10.23937/2469-5769/1510064
Prevalence of Femoral Head Ostenecrosis in Patients with Falciform Anemia: A Bibliographic Review in Pediatrics
Valeria Botelho, Ingridy Caroline Ferreira Silva, Paula Braga Daltro, Indiry Caroline Ferreira Silva, Rodrigo Jorge de Souza da Fonseca, Jane Mary de Medeiros Guimarães, Gildásio Daltro
Article Type: Review Article | First Published: June 25, 2020
An electronic search for studies developed in the last 20 years in the main databases was carried out: PUBMED, SCIELO, MEDLINE and BIREME using the descriptors: Femoral head osteonecrosis, sickle cell anemia, prevalence associated with Boolean operators: or and and. Studies published in English, pediatric age range between 0 and 18 years and studies available for access, were adopted as limits. At the end, 28 scientific articles were found. After reading the title and summary, only one study fit...
Open Access DOI:10.23937/2643-4563/1710024
Hepatosplenic Gamma Delta T-cell Lymphoma Presenting as Progressive Hepatosplenomegaly Highlighted during Pregnancy
Hussam Almasri, MD, Mahir Petkar, MBBS, MD, FRCPath, Abdulaziz Zafar, MBBS, MRCP, Mohammed Abuwahed, MBBS, Mohammad Altermanini, MBBCH, Rita Ahmad, MD and Mouhammad Sharaf Eldean, MD, FCAP
Article Type: Case Report | First Published: June 19, 2020
Hepatosplenic T-cell lymphoma (HSGDTL) is a rare variant of T-cell lymphoma with few reported cases in literature. It usually presents with hepatosplenomegaly and constitutional symptoms, primarily in young to middle aged patients. The prognosis is generally poor, with maximum reported survival periods of 2-3 years. There is a link to immunodeficiency and some biological treatments. Liver biopsy with flow cytometry is required to confirm the diagnosis....
Open Access DOI:10.23937/2378-3001/1410100
COVID-19 and Nervous System: Under Estimated Clinical and Prognostic Aspects
Alyne Barreto Mesquita de Goés, Bruno Barreira Cardoso, Francisco de Assis Fernandes Tavares, Rebecca Renata Lapenda do Monte, Renata Carneiro Melo, Irami Araújo- Neto, Renato Serquiz Elias Pinheiro, Amália Cinthia Meneses Rêgo and Irami Araújo- Filho
Article Type: Review Article | First Published: June 24, 2020
The coronavirus pandemic transformed the world abruptly due to the speed of transmission and high morbidity and mortality. Many deaths have been quantified, and the scientific community intensifies the search for molecular targets, protein sequences and polymorphismson SARS-CoV-2, to improve the clinical evolution and survival of patients. Initially, COVID-19 was described with respiratory changes, flu, and fever. With the spread of the disease, clinical manifestations were observed in other org...
Open Access DOI:10.23937/2378-3672/1410051
A Systemic Review: Structural Mechanism of SARS-CoV-2A Promising Preventive Cure by Phytochemicals
Dr. Roli Jain, Dr. Sandeep Shukla, Dr. Neeti Nema and Dr. Archna Panday
Article Type: Review Article | First Published: June 24, 2020
Phytochemicals are a powerful group of compounds, belonging to secondary metabolites of plants and including a diverse range of chemical entities such as polyphenols, flavonoids, steroidal saponins, organ Sulphur compounds, and vitamins. The potential biological benefits such as antioxidant, anti-inflammatory, anticancer, antibacterial, antifungal and antiviral activities. The ideal technology would be vaccine that gives lifelong immunity with a single dose. When whole world community of scienti...