Open Access DOI:10.23937/2378-2951/1410216
Coronary Risk Factors and its Reduction by Plant-Based Diet with Emphasis on Diabetes: A Preliminary Report
Gunadhar Panigrahi, MD, FACC, FACP, DipABLM
Article Type: Research Article | First Published: February 13, 2021
Heart disease has been the leading cause of death since 1933 in the US according to the mortality records from CDC. In 2009 coronary heart disease accounted for 64% of the cardiac deaths. This is due to diet high in processed foods, high in meat, saturated fat, added sugars and other high glycemic index carbohydrate, along with sedentary lifestyle. A comprehensive survey of cardiovascular disease of the New Guinea highlanders indicated rare incidence of ischemic heart disease, and no diabetes or...
Open Access DOI:10.23937/2378-2951/1410215
Left Ventricular Assist Devices and Their Role in Cardiogenic Shock: Literature Review and Contemporary Data
S Tzikas, AP Evangeliou, A Boulmpou, G Loufopoulos, CE Papadopoulos and V Vassilikos
Article Type: Review Article | First Published: January 30, 2021
Despite tremendous progress in the therapeutic algorithms of hemodynamically unstable patients, cardiogenic shock remains a clinical challenge with high mortality rate. Conservative management with inotropic agents remains the first-choice treatment, though it has been associated with serious adverse events and is not always adequate. Circulatory support with mechanical devices has been widely implemented in patients with cardiogenic shock during high- risk percutaneous coronary interventions or...
Open Access DOI:10.23937/2572-4142.1510010
Is Immunohistochemistry Enough to Diagnose Xp11.2 Renal Cell Carcinoma?
Paulo Victor Zattar Ribeiro and Leonora Zonula Pope, MD
Article Type: Commentary | First Published: February 05, 2021
The correct diagnosis methods of Renal Cell Carcinoma (RCC) with Xp11.2 translocations are controversial in the current literature. Due to the possible failures of immunohistochemistry alone. So we present a possible scientific based answer with the articles yet available. Renal cell carcinoma (RCC) with Xp11.2 translocations was delineated as a distinct entity in 2004 by the World Health Organization. It was primarily associated with TFE3 gene fusion and TFE3 protein overexpression in immunohis...
Open Access DOI:10.23937/2469-5823/1510153
Review of Feasibility Studies to Ensure Conducting the Proper Nursing Intervention Research
Michiyo Oka, RN, PhD, Satsuki Takahashi, RN, MHS and Mitsuhiro Matsumoto, RN, MSN, CNS
Article Type: Commentary | First Published: January 30, 2021
When introducing a new nursing system, it is the responsibility of the introducing side to incorporate what has been confirmed. However, it is difficult to conduct a large-scale randomized controlled trial (RCT) to confirm the evidence according to the protocol. Therefore, as a nursing researcher, we would like to utilize feasibility research. In this paper, we will introduce the necessity of feasibility study, the definition of feasibility study, and the parameters for high-quality feasibility ...
Open Access DOI:10.23937/2643-3966/1710036
Mitochondrial Dynamics and Cardiovascular Risk: An Insight at the Molecular Level
Ivan Lozada Martinez, Daniela Torres Llinás and Andres Llamas Nieves
Article Type: Commentary | First Published: February 06, 2021
Mitochondria are cellular organelles; whose function goes beyond generating adenosine triphosphate (ATP). They are part of the machinery involved in the production of substances related to iron, sulfur, and heme group, involved in lipid metabolism, calcium homeostasis, heat generation, cell signaling, stem cell pathway determination, and apoptotic processes. A vast variety of pathologies have been related to mitochondrial deficit, within these, cardiovascular diseases. Mitochondrial dysfunction ...
Open Access DOI:10.23937/2643-3966/1710035
Homocysteine Levels and Cardiovascular Risk: Potential Predictor of Morbidity and Mortality
Ivan Lozada Martinez, Daniela Torres Llinás and Andres Llamas Nieves
Article Type: Commentary | First Published: February 06, 2021
Homocysteine is a sulfurated amino acid, deriving out of methionine from the metabolism of the methyl group. It is a non-protein substance that has been associated with the dynamics of endothelial function, platelet activation, and leukocyte interaction, with the capacity to intensify the inflammatory response in the cardiovascular system, it is therefore considered a potential cardiovascular risk marker. Some studies have evaluated homocysteine in risk groups, where it has been found that the e...
Open Access DOI:10.23937/2378-3656/1410337
Myoclonus-Opsoclonus-Ataxia Syndrome Secondary to Advanced HIV Infection: A Rare and Atypical Case with Management Considerations
Ashley Ryan Vidad, OMS-III, Ahjay Bhatia, OMS-III, Himadri Shah, OMS-III, Divy Mehra, OMS-III, Shrinand Shah, OMS-I and Olu Ogunjemilusi, PGY-I
Article Type: Case Report | First Published: February 17, 2021
Opsoclonus-myoclonus-ataxia syndrome (OMAS) is a rare but serious neurologic disorder that commonly presents with both spontaneous multidirectional saccades (opsoclonus) and involuntary shock-like muscular contractions (myoclonus), but may or may not present with ataxia. This disorder has an incidence of 0.18 cases per million in the total population but has a higher incidence of 0.27-0.40 per million in children due to its link to specific pathologies. OMAS is mostly idiopathic or associated wi...
Open Access DOI:10.23937/2378-3656/1410336
Distal RTA with Hypokalemic Quadriparesis as the Initial Presentation of Primary Sjogren’s Syndrome
Tejaswee Banavathu, MBBS, Swapnil Tripathi, MBBS, Pankaj Sukhadiya, MBBS, Mahesh Kumar Barodia, MD and Gopal Krishna Bohra, MD
Article Type: Case Report | First Published: January 30, 2021
Sjogren syndrome (SS) is a multisystemic autoimmune disorder with predominant exocrine gland involvement leading to sicca symptoms. Among extraglandular manifestations, renal involvement is commonly seen. Renal involvement can be either tubulointerstitial (TIN) or glomerular, the former being more common. Distal RTA is the most common manifestation of TIN presenting as mild hypokalaemia, metabolic acidosis and rarely with hypokalaemic periodic paralysis. We report a case of a 70-year-old female ...
Open Access DOI:10.23937/2378-3656/1410335
High-Dose Intravenous Hydroxocobalamin for Persistent Vasoplegic Syndrome after Cardiac Surgery
Mohamed Ben-Omran, MD, Ellen Huang, PharmD, Vijay S. Patel, MD, Nadine Odo, BA, CCRC, Taylor Glenn MD and Vaibhav Bora, MD
Article Type: Case Report | First Published: January 30, 2021
Vasoplegic syndrome is a vasodilatory shock characterized by significant hypotension, normal or high cardiac output, and increased requirement for intravenous fluid resuscitation and vasopressors. It is a relatively common complication following cardiac surgery. We describe the case of a 77-year-old man who developed prolonged vasoplegic syndrome which was refractory to high doses of conventional vasopressors following coronary artery bypass graft surgery. Given the possible increased risk of se...