Orbital Apex Syndrome and Carotid Artery Injury Associated with Transorbital Stab Injury
Dimitri Laurent, MD, Brian Corlis, MD and Gregory JA Murad, MD
Article Type: Case Report | First Published: December 09, 2020
Transorbital penetrating injuries are particularly rare in the adult population. We present a case of TOPI sustained in an assault using a ballpoint pen-with concomitant transmaxillary injury due to a pencil stab wound-and a review of the literature. Transorbital penetrating injuries (TOPI) are particularly rare in the adult population, accounting for 0.096% of all head injuries. In the setting of TOPI, there should be a high index of suspicion for damage to the intracranial vascular and neural ...
CTGF Signaling in Skeletogenesis, Articular Cartilage, and Osteoarthritis Development
Eduardo Branco de Sousa and Diego Pinheiro Aguiar
Article Type: Review Article | First Published: December 21, 2020
CTGF/CCN2 is involved in many cellular events related to proliferation and migration. Its main physiological role is related to the promotion of endochondral ossification, besides regeneration, protection of bone and articular cartilage, and angiogenesis. Skeletogenesis, the process by which bone and articular elements are formed, comprises endochondral and intramembranous ossification. However, the signaling pathways that mediate CTGF/CCN2 expression in chondrocytes have not been fully understo...
Retrograde Air Flow through the Lacrimal Drainage System with Valsalva Maneuver
Swati Malik, B.A., Mohammad Javed Ali, F.R.C.S., Miel Sundararajan, M.D. and Harsha S. Reddy, M.D.
Article Type: Case Report | First Published: December 14, 2020
We present a series of three clinical videos of retrograde air flow through the lacrimal system with Valsalva maneuver that illustrate the hypothesized dysfunctions at various points within the lacrimal valvular system. Under normal physiologic conditions, the lacrimal excretory system has a series of valves that prevent retrograde flow of fluid and air. Therefore, while performing the Valsalva maneuver, increased intranasal pressure is not transmitted to the nasolacrimal system; however, trauma...
Musculoskeletal Pain and Postural Abnormalities among Smartphone-Using Digital Natives
Adesola C Odole, Dorcas A Olutoge, Oluwagbohunmi Awosoga, Chidozie E Mbada, Clara Fatoye, Olufemi O Oyewole, Ruth I Oladele, Francis A Fatoye and Aderonke O Akinpelu
Article Type: Original Article | First Published: December 16, 2020
The younger generations are labeled “digital native” among whom smartphone penetration and adoption is high. However, the health consequences of intense utilization of smartphones as a contributor to the increasing prevalence of musculoskeletal disorders in young adults are less explored. This study investigated patterns of musculoskeletal pain, postural abnormalities, and smartphone usage among undergraduate university students. Four hundred (200 males and 200 females) two-staged sampled un...
Personal Protection Equipment Utilization and Hand Hygiene Practice during COVID-19 Pandemic: A Narrative Review
Azmeraw Bekele and Yimenu Yitayih
Article Type: Review Article | First Published: December 16, 2020
Personal protective equipment and instant hand hygiene found the most effective preventive measures during coronavirus disease-19 and their utilization should depend upon contact-droplet exposure. The aim of the review was to evaluate when, where, and how the personal protective equipment utilized and hand hygiene practiced during SARS-CoV-2 infection. The following databases were searched using keywords and related browsing terms: PubMed Central, Ovid Medline via PubMed, Cochrane database, WHO ...
Hybrid Autopsy Virology Laboratory Experimental Platform
Izak B Dimenstein, MD, PhD, HT (ASCP)
Article Type: Commentary | First Published: December 11, 2020
The SARS-CoV-2 aerosols’ transmission route is not still settled. Along with epidemiology data, there is an urgent necessity for reliable reproducible experimental methods for virus aerosolization studies. The autopsy table can form part of a hybrid autopsy virology laboratory as an investigative platform equipped with the necessary instruments for SARS-CoV-2 aerosolization studies. Wide open mucosa surfaces COVID-19 deceased can be a field for studying under experimental manipulations of air ...
The Cardio-Vascular and Metabolic Treatments in Canada: Assessment of Real-Life Therapeutic Value Registry (CV-CARE): Registry Description and Baseline Patient Demographics
Goldenberg Ronald, Cheng Willoon, Bell Alan, Burrows Melonie Blavignac Jessica, Paron Emilia, Nadège Fils-Aimé and Barakat Maxime
Article Type: Research Article | First Published: December 12, 2020
Bausch Health Canada cardiovascular and metabolic treatment portfolio has been shown to be safe and effective in clinical trials. However, in clinical trials, data is collected in selective populations under ideal conditions, making inference to the real-world problematic. Well executed patient registries are required to provide evidence of the benefits of therapeutic agents under routine, real world conditions. The ‘Cardio-Vascular and metabolic treatments in Canada: Assessment of REal-life t...
Y Chromosome Sequences in Turner Syndrome: Multiplex PCR, a New Method for Diagnosis
Lene Garcia Barbosa Maria Anunciação Souza, Adriana Aparecida Siviero-Miachon, Magnus Régius Dias-da-Silva and Angela Maria Spinola-Castro
Article Type: Brief Report | First Published: December 02, 2020
Turner’s syndrome is characterized by the partial or complete absence of one of the sex chromosomes in women in association with one or more clinical exposures. Molecular techniques such as polymerase chain reaction (PCR) are useful when it comes to complementing the genetic approach, as they present greater sensitivity in recognizing mosaicism. Considering the high percentage of mosaicism and the possible clinical impact of the presence of Y chromosome in these patients, we proposed in this s...
The Effects of the Symptoms Experienced by Patients Undergoing Hemodialysis Treatment on their Comfort Levels
Rukiye Demir Dikmen and Hakime Aslan, PhD
Article Type: Original Article | First Published: December 17, 2020
This is cross-sectional study. The population of consisted of patients aged over 18 who received treatment at three hemodialysis centers in Elazig province and two in Bingol province. Sampling method was not used as it was aimed to reach the whole population. The research was carried out with 363 patients (84% of the population) meeting the research criteria. The data was collected between June-October 2019. Personal Information Form, Hemodialysis Comfort Scale (HDCS), and Dialysis Symptom Index...
The Transformation of Burnet’s Immune Surveillance Cells into Natural Killer Cells and its Circumstances
Joseph Geza Sinkovics and Joseph Csaba Horvath
Article Type: Case Report | First Published: December 17, 2020
In 1969 it was very difficult to explain the sudden unexpected appearance of some finely granulated large lymphoid cells that had been hidden in the human blood for over a full century, as they suddenly revealed themselves in our laboratory at M.D. Anderson Hospital, Houston TX. At first, the hematopathologists considered these cells to be of monocytoid (M) derivation; by accidental misprint, instead of monocytoid noted as “macrophagic” in the legends. These new cells appeared clearly distin...