Novel Insulin Receptor-Signaling Platform
Fiona Haxho, Farah Alghamdi, Ronald J Neufeld and Myron R Szewczuk
Article Type: Review Article | First Published: October 30, 2014
Insulin receptor (IR) signaling plays a key role in the regulation of glucose homeostasis. A dysfunctional and/or unregulated IR activation has been shown to cause a range of clinical manifestations including insulin resistance, type 2 diabetes, obesity, cancer, hypertension, and cardiovascular disorders. The molecular mechanisms mediating IR activation have become an important area of scientifi and clinical research. Here, we summarize the current understanding of IR structure, function, and si...
Endothelial Function in Obese and Overweight Patients: The Role of Olive Oil, Fish and Nuts
Marco Matteo Ciccone, Pietro Scicchitano, Francesca Cortese, Michele Gesualdo, Fara Fornarelli, et al.
Article Type: Research Article | First Published: October 22, 2014
Objective: To assess the effect of olive oil, non fried fih and nuts on endothelial function in overweight/obese patients.
Methods: 47 overweight/obese patients (24 men, mean age 54 +/- 11 years) fed healthy diet (HD) defied according to the NuretaPREDIMED study for 3 months; after this 3 months of HD, the patients were blindly divided into 4 groups: Controls (24: HD), Group A (8: HD+olive oil), Group B (8: HD+not-fried fih), Group C (7: HD+nuts). These four groups were also followed-up for fur...
HER2 Positive Gastric And Gastroesophageal Adenocarcinoma; An Irish Tertiary Center Experience
Yasir Y Elamin, Shereen Rafee, Mutaz M Nur, Nemer Osman, John V Reynolds, Cian Muldoon and Kenneth J O'Byrne
Article Type: Research Article | First Published: October 29, 2014
Background: Trastuzumab has been approved for patients with human epidermal growth factor receptor 2 (HER2) over expression and gene amplifiation metastatic gastric cancer. Here we present the prevalence of HER2 positive gastric cancer in an Irish population, the use of Trastuzumab in fist line and beyond progression.
Methods: The study was conducted in St James’s Hospital, Dublin. A retrospective analysis of the date of patients with HER2 positive gastric cancer over a period of 3 years was c...
Epidemiology and Radiotherapy of Hepatocellular Carcinoma
Article Type: Short Communication | First Published: October 27, 2014
Hepatocellular carcinoma (HCC) is a primary liver cancer secondary to chronic liver conditions such as hepatitis Bvirus (HBV) and C virus (HCV) infections, obesity and alcoholism. HCC is the sixth most common solid tumor, and third most lethal cancer globally. Thre may be a gender diffrence in the development and outcome of chronic liver diseases. In U.S., the incidence of HBV infection has declined since the introduction of HBV vaccination in 1981. But approximately 350 million of global popula...
Knowledge, Attitude and Screening Behaviour of Benue State University Male Students towards Prostate Cancer Awareness
Joyce M.Terwase, Chioma C. Asuzu and James A. Mtsor
Article Type: Research Article | First Published: October 18, 2014
The study investigated the influence of knowledge, attitude and screening behaviour of Benue State University Male Students towards prostate cancer awareness. Five research questions and research hypotheses guided the study. The study was a cross-sectional design utilizing a pretested 34-item Prostate Cancer Questionnaire (PCQ) (Cronbach’s alpha of 0.62) to collect information about knowledge, attitude and screening behaviour regarding prostate cancer among Benue State University Male students M...
Retinal Examination for the Diagnosis of Alzheimer's Disease
Umur Kayabasi, Robert C Sergott and Marco Rispoli
Article Type: Research Article | First Published: October 17, 2014
Objective: To demonstrate AD plaques in retina.
Methods: We examined 30 patients with Mild Cognitive İmpairment (MCI). In the patients in whom we found hyper or hypo florescent lesions on Fundus Auto Fluorescence (FAF), Optical Scanning Tomography (OCT) was performed through these regions to reveal depositions in the retina. Drusen like spots- dots were noticed in different parts of the retina. 20 randomly chosen patients and 20 age-matched healthy controls were given curcumin to check fo...
Supplementary Low - Dose Oral Ketamine Provides Better Parental Separation and Face Mask Acceptance
Zeinab Ahmed El Seify and Ahmed Metwally Khattab
Article Type: Original Article | First Published: November 01, 2014
Background: Anesthesia is stressful for children and parents. Although anxiolytics can keep children calm, side effects may exist. No single method shows a clear advantage in keeping the child calm and cooperative. This study aimed to test the effiacy and safety of adding a small dose ketamine to midazolam-based oral premedication on child-parents separation and acceptance of face mask.
Methods: Eighty preschool children scheduled for elective surgeries were included. Patients were allocated i...
Six Month Quality of Life of Trauma Patients from A Non- Trauma Regional Hospital in Singapore
Shahla Siddiqui, Lim WoanWui and Koh Kwong Fah
Article Type: Case Report | First Published: October 27, 2014
Introduction: Trauma is a leading cause of mortality and morbidity in Singapore. In our peripheral hospital we have a large trauma load despite being a non level one trauma center. Whilst we have many studies done in the West documenting the quality of life of trauma victims using scoring systems such as the EQ5DTM and GOSE, there is a paucity of literature from this part of the World.
Methods: We analyzed the results of 6 months of data collected by our trauma coordinator looking specifially ...
Environmental Risk Factors and Gene-Environment Interactions for the Development of Multiple Sclerosis
Article Type: Review Article | First Published: October 22, 2014
Multiple Sclerosis (MS) is an inflammatory demyelinating autoimmune disorder of the Central Nervous System (CNS). The typical disease course is Relapsing-Remitting (RR) MS and treatment with Disease Modifying Treatment (DMT) should be initiated as soon as possible following a diagnosis of relapsing MS for individuals with a first clinical event and MRI features consistent with MS, in whom other possible causes have been excluded. Patients with MS tend to do not completely recover from relapses w...
Celiac Disease in Multiple Sclerosis: A Controversial Issue
Silvia Salvatore, Alessandra Tozzo and Luigi Nespoli
Article Type: Review Article | First Published: October 22, 2014
Celiac disease is a common immune mediated disorder elicited by gluten that may manifest with neurological symptoms independent to gastrointestinal manifestations. The real prevalence of celiac disease in multiple sclerosis is still unclear because of limited population studies, different diagnostic assessment and possible non-celiac related response to gluten free diet. Recent studies have contributed to clarify genetic and immune overlap and discrepancy between the two conditions and are discu...