ClinMed International Library

The ClinMed International Library is a repository and an open access publisher for medical research that covers a wide range of areas in Clinical Medicine. ClinMed serves as a global platform for medical practitioners and research scholars to foster their learning and professional acumen through an extensive portfolio of research articles and publications that can be accessed without any restrictions.

Dedicated to clinical medical research, we now publish over 70 quality peer-reviewed journals making all the articles freely accessible. The manuscripts submitted to ClinMed will be processed through standard parameters and international peer review systems. This has enabled us to establish new milestones in the global research arena in terms of cogency and integrity, and to disseminate highly credible and accredited research content for researchers, scholars, and practitioners across the globe.

We ensure that all researchers and authors publishing their papers with us retain copyrights, licensed under Creative Commons Attribution License that permits the unrestricted use and re-use of the content with proper citation.

COVID-19 related research

Further Evidence of a Possible Correlation between the Severity of Covid-19 and BCG Immunization
Serge Dolgikh
Full article:90464112 | HTML:90464113 | DOI:10.23937/2474-3658/1510120
Strategies of the World Health Organization in the Covid 19 Outbreak
Emel Yürük Bal, (RN) MSc and Şenay Çetinkaya, PhD
Full article:90464112 | HTML:90464113 | DOI:10.23937/2474-3658/1510118
COVID-19 Threat to Major Global Urban Centers
Jean-dAmour K Twibanire
Full article:90464112 | HTML:90464113 | DOI:10.23937/2474-3658/1510116
Covid-19 Epidemic in Italy: Lesson Learning
Giangaspero M, DVM, MSc, PhD
Full article:90464112 | HTML:90464113 | DOI:10.23937/2469-5793/1510119
Modified Non-Invasive Computational Methods of HIV Drug Combinations for Treatment of Coronavirus Disease-19 (COVID-19)
Tamer Ezzat Youssef and Youssef Tamer Moustafa
Full article:90464112 | HTML:90464113 | DOI:10.23937/2469-567X/1510061
Epidemiology and Diffusion of Some Relevant Virus: Latitude, Air Pollutants and Humidity Role, Hypothesis of Work: Covid-19 Effect on the Air Pollution in Some World Region: What Implications?
Luisetto M, Ahmed Yesvi Rafa, Khaled Edbey, Ghulam Rasool Mashori, Farhan Ahmad and Oleg Yurevich Latyshev
Full article:90464112 | HTML:90464113 | DOI:10.23937/2572-4061.1510031
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Articles Search by   Keyword   |   Journal title   |   Author name   |   DOI

 Open Access DOI:10.23937/2378-3672/1410002

Cockroach Allergy, Respiratory Allergic Diseases and Its Immunotherapy

Oner Ozdemir

Article Type: Review Article | First Published: December 31, 2014

Cockroach allergen-derived proteases play a direct role on airway epithelial as well as dendritic cells thru activation of the protease activated receptor (PAR)-2. Cockroach-derived proteases lead to an increased penetration of cockroach allergen thru disturbing airway epithelial integrity, which can activate innate immune cells (e.g., dendritic cells) via binding to Toll-like receptor or C-type lectin receptors. The activated dendritic cells promote the adaptive immune system cells to a Th2 cel...

 Open Access DOI:10.23937/2378-3672/1410001

Polarization of Human THP-1 Macrophages: Link between Adenosine Receptors, Inflammation and Lipid Accumulation

Michael J. Littlefild, Isaac Teboul, Iryna Voloshyna and Allison B. Reiss

Article Type: Research Article | First Published: December 08, 2014

Rationale: Macrophages are key players in inflammation and atherosclerosis. They express surface receptors of different subtypes for the endogenous autocoid adenosine. Macrophages within atherosclerotic lesions attain two clear-cut functional phenotypes M1 (pro-inflammatory) and M2 (immunosuppressive). This study examines the relative expression of adenosine receptors and proteins involved in cholesterol transport in THP-1 human macrophages upon differentiation into M1 and M2 subtypes....

 Open Access DOI:10.23937/2378-3656/1410013

Recurrent Ischemic Strokes as the First Manifestation of A Pancreatic Cancer

Rosaria Renna

Article Type: Case Report | First Published: January 03, 2015

A 56-year-old Caucasian woman presented to the Emergency Department of our hospital with acute headache and a speech disorder characterized by mild aphasia and dysarthria. She had a history of arterial hypertension and nicotism for several years. Neurological evaluation at admission revealed mild motor aphasia and dysarthria (NIHSS: 2). Brain computed tomography (CT) showed two hypodense lesions, in the lef temporal and the right frontal lobes respectively. Results of laboratory tests revealed e...

 Open Access DOI:10.23937/2378-3656/1410012

Monitoring of the Left Recurrent Laryngeal Nerve during Mediastinoscopy is Feasible and Safe

Wolfram Karenovics, Sebastien Guigard, Besa Zenelaj, Marc Licker and Frederic Triponez

Article Type: Research Article | First Published: December 29, 2014

Objective: Left Recurrent Laryngeal Nerve (RLN) palsy is a well known complication of cervical mediastinoscopy and is not infrequent if specifically looked for. Electro-physiological monitoring of the RLN is common practice in thyroid surgery and has greatly improved outcomes. We applied the same technique during cervical video-mediastinoscopy. Patients and methods: Between October 2012 and October 2013 patients undergoing mediastinoscopy were enrolled prospectively for intra-operative monitorin...

 Open Access DOI:10.23937/2378-3648/1410011

Relationship of Mitochondrial DNA Haplogroups with Complex Diseases

Carlos G Urzua-Traslavina, Maria G Moreno-Trevino, Denisse A Martinez-Trevino, Hugo A Barrera-Saldana and Rafael BR Leon-Cachon

Article Type: Review Article | First Published: December 16, 2014

Mitochondria are responsible for energy production in unicellular and multicellular eukaryotes. Apart from their major role in metabolism, mitochondria are involved in many other cellular processes. A new paradigm is needed to understand aging, aging-related illnesses, and complex diseases. Because of the long co-evolution of mitochondria with the cells, subtle variations in the function of these organelles could influence many organ systems. Understanding the extent of this influence will shed ...

 Open Access DOI:10.23937/2378-3648/1410010

Oxidative Stress and the Epigenome in Human Disease

Adriana Arita and Max Costa

Article Type: Review Article | First Published: December 15, 2014

Epigenetics refers to the study of the changes in gene expression that occur without changes in the DNA sequence. There is growing evidence that epigenetic modifications such as changes in the levels of DNA methylation or post-translational histone modifications are involved in the pathogenesis of many human diseases including cancer. Oxidative stress as a result of metabolic or environmental factors leads to excessive production of reactive oxygen species (ROS). ROS plays a role in many human d...

 Open Access DOI:10.23937/2378-3648/1410009

Discordant Disease Course in a Monozygotic Twin Pair with Juvenile Myelomonocytic Leukemia

Silvia Bresolin, Paola De Filippi, Claudia Cagioni, Simone Cesaro, Annamaria Di Meglio, Anna Leszl, Fiorenza Aprili, Chiara Cugno, Chiara Frasson, Marco Zecca, Cesare Danesino and Geertruyte Kronnie

Article Type: Research Article | First Published: December 14, 2014

Juvenile myelomonocytic leukemia is a rare neoplastic disorder occurring in early childhood often showing an aggressive progression. We report a case of a twin pair with concordant JMML but an extremely different disease course. Both twins presented with somatic aberrations of chromosome 7 and mutations in PTPN11. Analysis of sorted BM and PB cell populations revealed the clonal nature of the disease and indicated that genomic aberrations arise from common hematopoietic precursor cells. PTPN11 m...

 Open Access DOI:10.23937/2378-3516/1410007

Eicosapentaenoic Acid Decreases Histamine Receptor 1 Expression on Lung Microvascular Endothelial Cells and Cell Permeability during LPS Stimulation

Takaaki Osako, Michiko Aoyama-Ishikawa, Hayato Yamashita, Makoto Usami, Atsunori Nakao and Joji Kotani

Article Type: Original Article | First Published: December 26, 2014

Introduction: During acute lung inflammation, the lung microvasculature becomes hyperpermeable, resulting in immune cell infiltration and tissue edema. N-3 polyunsaturated fatty acids (PUFAs), when used as a supplement in parenteral nutrition, can attenuate Lipopolysaccharide (LPS)-induced lung injury. In this study, we examined the effects n-3 PUFAs on lung microvascular cell permeability. Material and methods: Human lung microvascular endothelial cells (HMVEC-L) were seeded on fibronectin-coat...

 Open Access DOI:10.23937/2378-3516/1410006

Infective Endarteritis in a Patent Ductus Arteriosus

John Fani Srour

Article Type: Case Report | First Published: December 15, 2014

The ductus arteriosus, an essential fetal structure, normally closes spontaneously soon after birth. It's persistence into late adulthood is considered rare; infective endarteritis complicating a patent ductus arteriosus (PDA) is an even rarer event. The clinical picture of an infected PDA could be subtle, and the diagnosis is frequently delayed. Symptoms may well be attributed to community acquired pneumonia, pleurisy, or pulmonary infarction from pulmonary embolism. Occasionally, especially in...

 Open Access DOI:10.23937/2378-3664/1410006

Optimization and Validation of a New Method for the Production of Lipid Nanoparticles for Ophthalmic Application

Rosario Pignatello, Antonio Leonardi and Sarha Cupri

Article Type: Research Article | First Published: December 29, 2014

Within a wider research project aimed at the pre-industrial development of nanotechnology platforms for the treatment of eye diseases, this work exploited the possibility of obtaining solid lipid nanocarriers (SLN) using ingredients and operating conditions that could be compatible with the technological requirements of medical formulations used for ophthalmic therapies and, above all, capable of an easy industrial scale-up....

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Featured Journals

Clinical Medical Reviews and Case Reports Editor-in-chief: Prof. Wei Wang

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International Journal of Clinical Cardiology Editor-in-chief: Prof. Breijo-Marquez

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International Journal of Cancer and Clinical Research Editor-in-chief: Prof. Sulma I Mohammed

International Journal of Diabetes and Clinical Research Editor-in-chief: Prof. Masayoshi Yamaguchi

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International Journal of Sports and Exercise Medicine Editor-in-chief: Prof. J David Prologo

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International Journal of Psychology and Psychoanalysis Editor-in-chief: Prof. Joaquim JF Soares

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International Journal of Clinical Biostatistics and Biometrics Editor-in-chief: Prof. James Michael Hardin