Deep Brain Stimulation Frequency Modulation in Parkinson Disease - One Size May Not Fit All
Ritesh A. Ramdhani
Article Type: Editorial | First Published: September 11, 2014
Deep Brain Stimulation (DBS) is an effective therapeutic modality for patients with Parkinson's Disease who have developed complications from longstanding levodopa such as dyskinesias and motor fluctuations. It produces robust responses to segmental symptoms (ie, bradykinesia, tremor, rigidity) while attenuating involuntary dyskinetic movements and smoothing out 'on' and 'off' period cycling. The subthalamic nucleus and the globus pallidus internaare widely accepted surgical targets for stimulation therapy, with STN more commonly used, though superiority has not been established....
Is Allogeneic Hematopoietic Cell Transplantation Still an Option for Chronic Lymphocytic Leukemia in the Era of BTK Inhibition?
Josh D. Simmons and Jeremy Pantin
Article Type: Editorial | First Published: September 08, 2014
Chronic lymphocytic leukemia (CLL) remains the most common adult leukemia in Western countries. Over the last several decades, there has been an evolution in therapeutic options from single-agent alkylating agents to purine analog-containing regimens, as well as chemo-immunotherapy combinations. Despite the high initial response rates reported with conventional chemo-immunotherapy, patients invariably relapse and may subsequently develop resistance to further conventional therapy.Unfortunately, there is no evidence to date that conventional therapy is curative.Allogeneic hematopoietic cell tra...
Isnt it the Timing for Physics Guidelines on High Dose Rate (HDR) Brachytherapy for Localized Prostate Cancer?
Article Type: Editorial | First Published: August 23, 2014
Prostate cancer has been known as the most frequently occurring (233,000 estimated new cases in 2014) and the secondly death-causing (29,480 estimated deaths in 2014) for men in the United States of America. Based on the extension of tumor, prostate cancer is staged in the Tumor-Node-Metastasis (TNM) scoring system. Depending upon clinical TNM staging, prostate-specific antigen (PSA) level (ng/mL) and pathologic biopsy denoted as Gleason sum score (GSS), localized prostate cancer patients are categorized into three risk groups according to the National Comprehensive Cancer Network (NCCN) guide...
Single-Incision Laparoscopic Morgagni Hernia Repair in an Adult
Sharon Monsivais, Nicole E. Sharp, Hannah Vassaur and F. Paul Buckley
Article Type: Case Report | First Published: September 07, 2014
Introduction: This is a case report of a single-incision laparoscopic Morgagni hernia repair. We discuss our initial experience with this technique.
Case Description: A 63-year-old man elected to undergo a single incision laparoscopic Morgagni hernia repairs after diagnostic imaging showed a large fat containing right diaphragmatic hernia. The patient's only preoperative symptom was periodic right sided chest pain....
Induced Pluripotent Stem Cells and Heart Failure Therapy
Article Type: Editorial | First Published: August 23, 2014
Heart failure is a major public health concern worldwide, and coronary artery disease in particular is the leading cause of death in developed countries. Percutaneous coronary interventions can effectively treat coronary artery disease, but the management of ventricular remodeling and chronic ischemic cardiomyopathy after Myocardial Infarction (MI) remains a challenge. The human heart has very limited regenerative capacity, which is insufficient to replace the cells lost after MI. Stem cell therapy is a promising new approach to restoring cardiac function and preventing ventricular remodeling ...
Boron Neutron Capture Therapy of Cancer as a Part of Modern Nanomedicine
Alexander V. Safronov
Article Type: Editorial | First Published: August 16, 2014
Boron neutron capture therapy (BNCT) is a method of cancer therapy with a simple idea behind it. Positioning a certain amount of 10B-enriched boron-containing compounds into tumor cells with subsequent irradiation of the tumor tissue by thermal or epithermal neutrons causes tumor damage and death. The mechanism of the tumor cell damage during BNCT is based on the capture-fission reaction between the boron-10 nucleus and a neutron resulting in an α-particle release inside the cell. A successful BNCT therapeutic agent must obey several requirements, most importantly it should (1) selectivel...
International Journal of Cancer and Clinical Research- Commited to Ensure Quality Publication in Cancer Research
Sulma I. Mohammed
Article Type: Editorial | First Published: August 20, 2014
With great pleasure we welcome you to the inaugural issue of the International Journal of Cancer and Clinical Research. We envision this journal to provide a platform for all cancer researchers around the world to publish their high quality findings in cancer and clinical research as well as a venue to nurture researchers and young investigators in developing countries. The journal aims to accelerate the pace of research, discovery and innovation in clinical research around the globe....
Intrathecal Dexmedetomidine or Meperidine for Post-spinal Shivering
Mohamed Hamdy Ellakany
Article Type: Research Article | First Published: September 11, 2014
Background: Shivering occurs frequently during the perioperative period. A prospective, randomized, double-blind study was done to compare between intrathecal dexmedetomidine (5mcg) and intrathecal meperidine (0.2mg/kg) for decreasing the incidence and intensity of shivering after spinal anesthesia for lower abdominal operations.
Methods: Seventy five patients scheduled for lower abdominal operations under spinal anesthesia were randomly allocated to three groups. Spinal anesthesia consisted of 12.5 mg hyperbaric bupivacaine 0.5% in addition to dexmedetomidine (5mcg) (group D) or meperidine ...
Validity of Creatine Kinase as an Indicator of Muscle Injury in Spine Surgery and its Relation with Postoperative Pain
Domingo Lombao Iglesias, Joan Bago Granell, Teresa Vilor Ribero
Article Type: Research Article | First Published: September 10, 2014
Injury to the paraspinal muscle during posterior spinal surgery has been related to the intensity of postoperative pain. The aim of the study was to confirm the validity of serum postoperative creatine kinase (CK) values as an indicator of muscle lesion as well as to assess the relationship of CK with variables indicating surgical invasiveness and investigate the association between CK values and excessive postoperative pain.
Material and Method: The study included 96 patients (mean age 62.8 years) who underwent instrumented spine fusion for degenerative lumbosacral disorders. Serum CK conce...