The Role of Neurostimulation in the Treatment of Epilepsy- A Commentary on the State of Its Use and Its Potential Worldwide
Arun Swaminathan, MD
Article Type: Editorial | First Published: February 22, 2020
Vagal nerve stimulation (VNS) represents the earliest and longest used method of neuromodulation for epilepsy. Implanted and transdermal VNS approaches have both been used and the implanted technique has been proven to be more superior and has become the procedure of choice. VNS implants offer a good treatment option for generalized, multifocal and inoperable epilepsies and are often preferred by patients who wish to have the least invasive option used in them. The VNS also offers relatively good results in patients with focal epilepsies that may be unable or unwilling to undergo more invasive...
Origami-Induced Alignment of MNP Inside of DNA Nanotubes
Adele Rafati, Ali Zarrabi and Pooria Gill
Article Type: Original article | First Published: February 20, 2020
The advent of nanotubes in the nanotechnology world has led to significant advances in a number of biological and materials application, due to their structural properties such as the surface to volume ratio and potential to surface carrying or inside capsulation any materials. Among the various types of nanotubes, DNA nanotubes, due to their unique characteristics, such as precis controllability and programmability in shape/size/length/diameter and its biological origin compared to different types of nanomaterial, can be the suitable candidate for template patterning alignment and precise org...
Effect of Lactobacillus Rhamnosus GG on the Number and Differentiation of T Lymphocytes in the Intestine of Early Weaned Piglets
Seria Masole Shonyela, Bo Fong, Wentao Yang, Guilian Yang and Chunfeng Wang
Article Type: Research Article | First Published: February 20, 2020
In recent years, with the rapid development of Chinas breeding industry, the weaning age of piglets is also in advance. The weaning time of piglets determines the number of piglets per year and the reproduction rate of sows. At the same time, the earlier weaning the piglets, the lower the production cost. However, early weaning of piglets will have a series of adverse effects on piglets. First of all, piglets will suffer from malnutrition due to early weaning, and their growth and development will be affected. Secondly, breast milk contains a large number of antibodies. Early weaning will caus...
Simplified Neutrophil Isolation Protocol
Antonio Muniz-Buenrostro, Alma Y Arce-Mendoza, Edgar I Montes-Zapata, Rubi C Calderon- Melendez and Maricruz J Montelongo-Rodriguez
Article Type: Original Article | First Published: February 13, 2020
Neutrophils are the most abundant leukocytes in humans and among the first cells to arrive on the site of inflammatory immune response. Due to their key role in inflammation, neutrophil functions such as locomotion, cytokine production, phagocytosis, respiratory burst and release of extracellular traps are extensively studied. In the presentstudy, we present a simplified neutrophil isolation protocol which has excellent reproducibility and low cost. Taken together, our findings point to the fact that this protocol can be used in any lab around the world, but is mainly focused in labs with low ...
Total Flavonoid Extract of Pseudocedrela kotschyi (Schweinf) Harms (Meliaceae) Inhibits the Pro-Inflammatory Function of Asthmatic Patients Neutrophils
Oumar Mahamat, Guessom K Oulianovie, Tume Christopher and Kamanyi Albert
Article Type: Research Article | First Published: February 12, 2020
Asthma is one of the most common chronic diseases worldwide affecting approximately 300 million individuals. Asthma or anaphylaxis are allergic diseases essentially characterized by eosinophilia and mast cells release histamine which is responsible for the production of IgE. Nevertheless, neutrophils are highly implicated and it is demonstrated in about 50% of asthma cases. Consecutive to bronchial allergen challenge for example, there is an influx of neutrophils in proximal and distal airways. In asthmatic patients, neutrophils are known to be hyperactive, characterized by a production of num...
An Atypical Soft Tissue Mass on the Dorsum of the Foot: A Case Report
Kirmanj Atrushi PGY-3, DPM
Article Type: Case Report | First Published: February 17, 2020
Evaluating and treating soft tissue masses is a component of podiatric practice that few will be able to avoid. Indeed, of all soft tissue masses, ganglion cysts appear to be the most common. Many of these can be adequately treated with fine-needle aspiration. However, in other cases, surgical excision may be indicated, particularly when the cyst is pressing against a nerve or similarly sensitive structure. In this case report we seek to analyze one case of a painful soft tissue mass that was originally diagnosed as a ganglion cyst, had failed fine-needle aspiration, and was analyzed under MRI...
Case Report: Lymphatic Drainage Resolves Toe Walking Gait in a Boy with Autism Spectrum Disorder
Susan Vaughan Kratz, OTR, CST-D
Article Type: Case Report | First Published: February 14, 2020
Describe how lymphatic drainage (LD) resolved obligatory toe walking gait and stance in a boy with Autism Spectrum Disorder (ASD). The treatment plan was generalized from an identical treatment given to a collegiate athlete with chronic spasms of gastronemii. A single treatment of LD. No literature suggests a fluid anatomy model for manual therapies as treatment options for toe walking. This case highlights an effective method discovered to quickly reverse functional deformities despite several years of traditional pediatric interventions for toe walking in ASD....
Organophosphate Poisoning and Suicide in Nepal: A Reflection on the limitations of Behavioral Health Resources
Tyler Johnston, MS, Kris Brickman, MD, Roshana Shrestha, MD, Anmol Shrestha, MD and Shaza Aouthmany, MD
Article Type: Case Report | First Published: February 15, 2020
Organophosphate poisoning is the most common cause of suicide attempt in Nepal. Mortality rates of organophosphate poisoning are 41 times higher than they are in the United States, even with appropriate treatment. In low middle income countries organophosphate poisoning is much more prevalent than any other forms of suicide due to the easy availability in these agricultural countries. The most common cause of organophosphate poisoning for intentional suicide is from depression. Social reforms within the country to address the stigma related to mental health problems and improved data collectio...
Evaluation of Accidents and Injuries in International Rally Organizations Held in Turkey
Ramazan SABIRLI, Damla ANBARLI METIN, Emre KARSLI and Omer CANACIK
Article Type: Original Research | First Published: February 13, 2020
International rally events, such as the World Rally Championship (WRC) and the Bosphorus Rally and the World Rally Cross Championship (WRX), have been held in Turkey from 2014 onwards. WRX race is an asphalt runway race in which two different categories of vehicles (Super car and RX-Lite) are racing and the rally racers aim to get the first place by passing one another. Super cars have approximately 650 hp engine, RX-Lite cars have approximately 380hp engine. Having been known since 1967, rallycross was organized under the name of WRX in 2014. WRX was held in the Istanbul Park circuit on 01-02...
Clostridium Sporogenes Causing Bacteremia Originated from the Skin and Soft Tissue Infection in an Immunocompetent Patient - Case Report and Literature Review
Harith A Alataby, MD, Vaishali Krishnamoorthy, MD, Laura Ndzelen, MD, Foma Munoh Kenne, MD, Kate Valenti, MLT, Jessie Savermuttu, MD and Jay Nfonoyim, MD
Article Type: Case Report | First Published: January 15, 2020
The genus Clostridium comprises of over 200 described species that are associated with a variety of toxin-mediated as well as invasive infections, such as bacteremia, gas gangrene, foodborne botulism, and antibiotic- associated colitis. Clostridium sporogenes is one of the members of the genus Clostridium that is considered to be a significant cause of food spoilage. However, it is rarely recognized as a clinical pathogen. Less than 25 cases of infection secondary to this organism have been reported so far. In this report, we present a case of bacteremia in an immunocompetent patient, which wa...