Cardiology and the New Decade
Article Type: Editorial | First Published: September 29, 2014
Greetings to all readers as we move in to the era of science and technology. Let us hope to witness several exciting developments in the field of cardiology that would pave way to the cure of many cardiological disorders in this new era. This year the International Journal of Clinical Cardiology is debuting in field of open access. We hope to bring to you some of scientific excitements. There had been much progress in the field of Heart Transplantation Surgery. Doctors and Researcher from all across the world has summarized these developments and has challenged us to meet the future scenario, ...
Plasma Homocysteine Levels in Neuromyelitis Optica
Lei Zhang, Yaqing Shu, Shaoyang Sun, Yinyao Lin, Yanqiang Wang, Bingjun Zhang and Xuejiao Men
Article Type: Original Article | First Published: October 30, 2014
Background and purpose: Homocysteine has been implicated in many kinds of neurologic diseases by inducing oxidative injury which is considered one of the pathogenic mechanisms of neuromyelitis optica (NMO). The aim of this study was to investigate whether there were any relationship between plasma homocysteine and clinical features of NMO patients.
Methods: We measured plasma homocysteine in 66 patients with NMO and 66 controls.
Results: The patients with NMO had significantly higher homocysteine level than that of healthy control (P<0.001). The average homocysteine level of patients with ...
The Character and Frequency of Muscular Pain in Myotonic Dystrophy and Their Relationship to Myotonia
Parmova O, Vohanka S, Strenkova J
Article Type: Research Article | First Published: October 29, 2014
Background: Myotonic dystrophy is the most common form of muscular dystrophy in adults. Pain is reported in various hereditary muscular diseases at a frequency of 64%–83%.
Methods: A group of 70 patients with myotonic dystrophy (21 persons with type 1 and 49 with type 2) was investigated by means of questionnaires structured around the subject of pain.
Results: The frequency of long-term muscle pain was 57% in patients suffering from myotonic dystrophy type 1 and 55% among those with type 2. Presence of pain at examination was reported by 52% of patients with myotonic dystrophy type 1 and ...
Effect of Yogic Practices on Mental Health of Orphans Children
Morteza Alibakhshi Kenari
Article Type: Research Article | First Published: October 27, 2014
Orphan children suffer greatly from much physical, physiological and mental disorders leading to the bad effect on their, over-all adjustment, emotional stability autonomy, security-insecurity, intelligence and self concept. Yogic practices are providing the best method to achieve good mental health. Thus keeping in view the benefits of yogic practices, an attempt has made to investigate scientifically the effect yogic practices on mental health of orphan children. In this study the investigator has selected the 60 (Boys and Girls) orphan children from Guru Nanak Ananth Ashram (Orphan Home) Ja...
Cerebellar Stroke in Children, Case report from Qatar & Brief Literature Review
Abdulhafeez M Khair, Mahmoud Elseid, Khalid Mohamed, Rana Al-shami, Khalid Ibrahim and Ahmed Elsotouhy
Article Type: Case Report | First Published: October 27, 2014
Introduction: Cerebro-vascular accidents do happen for both adults & children. Pediatric data in contrary to adult data are clearly defiient & lacking behind. Childhood cerebellar strokes are much more rare & diffiult to pick up.
Case Report: We are reporting a toddler girl, who happened to be an ex premature & part of quadruplet. She presented with severe headache & head tilting in the absence of other focalizing CNS symptoms. Her brain MRI showed changes suggestive of cerebellar stroke. Patient improved clinically & radiologically after proper therapy.
Discussion: Cerebellar infarctions ...
Anti Citrullinated Protein / Peptide Antibody Assay, Rheumathoid Factor or Both as Shifted Test in Diagnostic and Prognostic Evaluation in Patients with Rheumathoid Arthritis
Dejan Spasovski, Tatjana Sotirova, Svetlana Krstevska-Balkanov, Maja-Slaninka-Micevska, Trajan Balkanov, Sonja Alabakovska, Sonja Genadieva-Stavric
Article Type: Research Article | First Published: October 27, 2014
Aim: The aim of this study was to compare the diagnostic values of laboratory variables, to present quantitative evaluations of the anti citrullinated protein / peptide antibody (ACPA), or anti CCP ( anti-cyclic citrullinated peptide, anti-CCP 2) antibodies in second generation antibody assay diagnostic test with reference to sensitivity and specifiity, the predictive value of the positive and negative test and precision of the test for ACPA antibodies, rheumatoid factor, C-reactive protein and DAS 28 index, in the early diagnosis of untreated rheumatoid arthritis.
Materials and methods: 70 ...
Aspergillus flavus Blast2GO Gene Ontology Database: Elevated Growth Temperature Alters Amino Acid Metabolism
Perng-Kuang Chang and Leslie L. Scharfenstein
Article Type: Research Article | First Published: October 05, 2014
The availability of a representative Gene Ontology (GO) database is a prerequisite for a successful functional genomics study. Using the online Blast2GO tool we constructed a GO database of Aspergillus flvus, a plant and human pathogen. Of the predicted total 13,485 A. flvus genes 8,987 were annotated with GO terms. The mean GO level was 5.64. Using a low stringency setting of a sequence cut-off number of 10 and a node score of 20, we obtained 1,177 GO terms associated with biological process, 388 GO terms associated with molecular function and 200 GO terms associated with cellular component. ...
Novel Insulin Receptor-Signaling Platform
Fiona Haxho, Farah Alghamdi, Ronald J Neufeld and Myron R Szewczuk
Article Type: Review Article | First Published: October 30, 2014
Insulin receptor (IR) signaling plays a key role in the regulation of glucose homeostasis. A dysfunctional and/or unregulated IR activation has been shown to cause a range of clinical manifestations including insulin resistance, type 2 diabetes, obesity, cancer, hypertension, and cardiovascular disorders. The molecular mechanisms mediating IR activation have become an important area of scientifi and clinical research. Here, we summarize the current understanding of IR structure, function, and signaling, and highlight the role of glycosylation and sialylation in IR activation. The key interacti...
Endothelial Function in Obese and Overweight Patients: The Role of Olive Oil, Fish and Nuts
Marco Matteo Ciccone, Pietro Scicchitano, Francesca Cortese, Michele Gesualdo, Fara Fornarelli, et al.
Article Type: Research Article | First Published: October 22, 2014
Objective: To assess the effect of olive oil, non fried fih and nuts on endothelial function in overweight/obese patients.
Methods: 47 overweight/obese patients (24 men, mean age 54 +/- 11 years) fed healthy diet (HD) defied according to the NuretaPREDIMED study for 3 months; after this 3 months of HD, the patients were blindly divided into 4 groups: Controls (24: HD), Group A (8: HD+olive oil), Group B (8: HD+not-fried fih), Group C (7: HD+nuts). These four groups were also followed-up for further 15 months. All patients were evaluated at baseline, at 3 and 18 months for glucose and lipid pr...