Acute Pneumonia: The Beginning of a Revision of Views or Just a Statement of Known Facts?
Igor Klepikov, MD
Article Type: Commentary | First Published: March 14, 2020
The author conducted research on the topic under discussion in the USSR at the State Institute for advanced training of doctors (Novokuznetsk). To date, the USSR and the mentioned Institute no longer exist. However, research and clinical trials of new approaches to the treatment of children with acute pneumonia and the results of this work can provide answers to a number of questions facing us today, which allows us to consider the research of thirty years ago relevant and worthy of mention....
Safety and Effectiveness of Neuromuscular Blockers in the Treatment of Acute Respiratory Distress Syndrome: Systematic Review and Meta-Analysis
Alfredo Aisa-Alvarez MsC, MD, Cesar A Rojas-Gomez, MD and Gilberto Camarena-Alejo MHA, MD
Article Type: Research Article | First Published: March 07, 2020
Two review authors independently screened the abstracts and titles for relevance. Screening for inclusion, data extraction, and risk of bias assessment were performed by one author and checked by the second. We assessed trials for the overall quality of evidence using the Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) instrument. We calculated the risk ratios (RR) and 95% confidence intervals (95% CI) for dichotomous outcomes, while for continuous results we obtained the mean difference and performed a random-effects meta-analysis. Six RCTs including 3351 patients...
Proteasome and Autophagy Pathway in Corneal Epithelial Cells with Limbal Stem Cell Deficiency
Fawzia Bardag-Gorce, Michael Di Lorenzo, Robert Niihara, Sarah Sunada, Amanda Laporte, Kavita Narwani, Daileen Cortez, Jeremy Stark, Mynor Garcia, Alissa Diaz, Joan Oliva, Richard Hoft, and Yutaka Niihara
Article Type: Original Article | First Published: February 28, 2020
Immunofluorescent staining showed that both pathways were positive in normal corneal epithelium. However, while proteasome subunits were decreased in LSCD-CEC, autophagy biomarker MAPLC3B and ATG12-ATG5 complex were significantly increased in LSCD-CEC, compared to healthy CEC. These results indicate that LSCD-induced impairment of UPP may cause a compensatory stimulation of autophagy. However, despite autophagy up regulation, damaged and unwanted proteins, such as modified keratin K4 and K13 aggregates, still deposited and accumulated in LSCD-CEC without clearance, possibly contributing to CEC...
Is Revisional Bariatric Surgery Effective as Primary Surgery?
Hakan Seyit, MD and Halil Alis, Professor
Article Type: Research Article | First Published: February 29, 2020
The study included randomly selected 350 PS patients for control group and 35 RS patients for study group. Prospectively-collected patient data were retrospectively reviewed. To measure the efficacy of the procedure, we calculated the excess weight loss percentage (EWL%). Effective weight loss was accepted as more than 50%. The changes in the status of the comorbid diseases, complications (leakage, bleeding and stenosis), weight loss, % excessive weight loss (EWL) and mortality were recorded. To summarize the first to systematically discuss results of primary surgery versus revisional surgery ...
Does Emu Oil Have a Role in the Relief of Non-Specific Pain? A Systematic Review of Clinical Trials Involving Emu Oil
David Sherwood, DO, Benjamin Gill, DO, MBA and Derick Schirmer, MS
Article Type: Original Article | First Published: March 13, 2020
Given a previous review on emu oil from 2014, which concluded a lack of clinical trial evidence, these authors set out to summarize the literature with regard to emu oil use for non-specific pain management. Non-specific pain management was selected as Google Trend data suggest that emu oil may be commonly amongst the general population for the treatment of non-specific pain. Using PRISMA guidelines, three randomized, controlled trial studies were identified, which found either no statistically significant difference between emu oil and placebo for pain relief or used a compound, which made it...
Teaching Communication Skills in Children and Adolescents with Severe To Profound Neurodevelopmental Disorders through Aided-Alternative and Augmentative Strategies
Article Type: Editorial | First Published: March 14, 2020
Children and adolescents with severe to profound neurodevelopmental disorders (e.g., attention deficit hyperactivity disorders, autism, cerebral palsy, rare genetic syndromes) may have intellectual, motor, and sensorial delays. Additionally, they may experience communication difficulties and exhibit isolation, passivity, and withdrawal. Challenging behaviors (e.g., aggression, impulsivity, stereotypic movements, and tantrum behavior) may occur. Their clinical conditions may seriously hamper their social desirability, image, and status with deleterious outcomes on their quality of life...
Effects of TSH on Erythrocyte Osmotic Fragility: Signaling Pathway
Evelyn Mendonca-Reis, Camila Cristina Guimaraes Nobre, Artur Paes-Chagas, Leandro Miranda-Alves and Clemilson Berto-Junior
Article Type: Original Article | First Published: March 09, 2020
TSH is a peptide hormone synthetized and secreted by pituitary with fundamental importance for thyroid function. TSH receptors are found in other tissue than thyroid playing diverse roles, including erythrocyte. Based on the fact that deformability is one of the most important features of a mature erythrocyte, we aimed to verify if TSH modulates erythrocytes volume and, if does, which signaling is involved in this modulation. Using hemolysis assay, we create a hemolysis curve of erythrocyte in presence of TSH in different concentrations (1, 2, 3 and 5 mIU/L). By adding AICAR, Wortmannin and Ak...
Successful Management of Hyperosmolar Hyperglycaemic State with Oral Hypoglycaemics in a Rural Setting - A Case Report
Jeremy Kay Hock Lee, Aaron Kwun Hang Ho and Lin Ho Wong
Article Type: Case Report | First Published: February 29, 2020
Hyperosmolar Hyperglycaemic State (HHS) is a diabetic emergency which requires prompt restoration of haemodynamic stability due to high early mortality. There is currently no study which recommends the use of oral hypoglycaemics to lower blood glucose levels, due to the high efficacy of parenteral Insulin. We report a case of our management of HHS using oral hypoglycaemics (Metformin and Gliclazide) due to the absence of parenteral Insulin in a rural setting, with remission of symptoms, stabilization of vitals and a significant decline in Random Capillary Blood Glucose (RCBG) levels in our pat...
Molecular Detection of Human Papilloma Virus Type 16 among Conjunctival Intraepithelial Neoplasia Patients in Khartoum State, Sudan
Hala H Ahmed, Aya A Almtry, Isra M Aidrous, Sara M Ali, Mohamed H Arbab and Ali M Badri
Article Type: Research Article | First Published: February 29, 2020
Many factors like exposure to UV radiation, climatic conditions, genetic predisposition, immunological state and, more recently, the presence of HPV have been implicated in the genesis of some lesions of the conjunctiva, especially the carcinoma. The study was carried out to detect Human Papilloma Viruses HPV type 16 in conjunctival intraepithelial neoplasia patient in Khartoum state, Sudan during the period from March to July 2019. A total of 50 Formalin-fixed paraffin- embedded Samples were collected from conjunctival intraepithelial neoplasia patients attending the Radiation-Isotopes Centre...