ClinMed International Library

The ClinMed International Library is a repository and an open access publisher for medical research that covers a wide range of areas in Clinical Medicine. ClinMed serves as a global platform for medical practitioners and research scholars to foster their learning and professional acumen through an extensive portfolio of research articles and publications that can be accessed without any restrictions.

Dedicated to clinical medical research, we now publish over 70 quality peer-reviewed journals making all the articles freely accessible. The manuscripts submitted to ClinMed will be processed through standard parameters and international peer review systems. This has enabled us to establish new milestones in the global research arena in terms of cogency and integrity, and to disseminate highly credible and accredited research content for researchers, scholars, and practitioners across the globe.

We ensure that all researchers and authors publishing their papers with us retain copyrights, licensed under Creative Commons Attribution License that permits the unrestricted use and re-use of the content with proper citation.

ClinMed International Library

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Articles Published

All articles are fully peer reviewed, free to access and can be downloaded from our ClinMed archive.

Articles Search by   Keyword   |   Journal title   |   Author name   |   DOI

 Open Access DOI:10.23937/2572-4045.1510007

Impact of Donor Cytomegalovirus Serology and duration of Prophylaxis on Follow-Up Strategy in Lung Transplant Recipients

Jose M. Borro, Maria Delgado, Teresa Rey and Pablo Rama

Article Type: Original Article | First Published: July 04, 2015

Cytomegalovirus (CMV) infection is the most prevalent opportunistic infection after lung transplantation. It is reported in between 20% and 50% of cases after discontinuation of prophylaxis, depending on the series. CMV usually remains dormant in the lymphatic system, and its reactivation, due to immunosuppressive therapy, may have considerable adverse consequences in the immunocompromised host. Its many and varied effects include inflammation, increased morbidity, and decreased graft and patient survival....

 Open Access DOI:10.23937/2378-3419/2/3/1019

Screening for the Polyomaviruses BKV, JCV and SV40 in Pediatric Malignancies

Karin Kosulin, Alexander Zimmerhack, Johannes A. Hainfellner, Christine Haberler, Gabriele Amann, Susanna Lang and Thomas Lion

Article Type: Research Article | First Published: July 31, 2015

Different studies suggested an oncogenic potential of the polyomaviruses JC virus, BK virus and simian virus 40, particularly in brain tumors and neuroblastoma, which belong to the most frequent malignancies in children. However, currently available data are controversial, possibly due to the different regional prevalence of the viruses and the detection techniques used. To elucidate the presence of these polyomaviruses in the indicated tumor entities and in childhood cancer in general, we have investigated a broad spectrum of pediatric malignancies, with particular emphasis on neuroblastoma f...

 Open Access DOI:10.23937/2474-3674/1510002

Use of Dexmedetomidine in the Management of Alcohol Withdrawal Syndrome in Critically Ill Patients

Julie Kalabalik and Jesse B. Sullivan

Article Type: Review Article | First Published: July 30, 2015

Alcohol consumption plays a role in the development of over 200 diseases and conditions in individuals worldwide, including liver cirrhosis, cancers, traumatic injury, and alcohol dependence. In hospitalized patients with alcohol use disorders (AUD), up to 25% will develop acute alcohol withdrawal syndrome (AWS). In critically ill patients, presence of AWS is associated with increased duration of mechanical ventilation, prolonged intensive care unit (ICU) length of stay (LOS), more frequent infectious complications and higher mortality....

 Open Access DOI:10.23937/2378-3648/1410016

Understanding the Host Epigenetics in Mycobacterium tuberculosis Infection

Vinod Yadav, Ved Prakash Dwivedi, Debapriya Bhattacharya, Ashwan

Article Type: Research Article | First Published: June 27, 2015

It was in 1942 when C.H. Waddington first coined the term epigenetics. According to him there is no direct relationship between a gene and its phenotype. He considered epigenetics as a part of development biology and in his opinion many times genotype and phenotype variations are not associated and phenotype differences do not necessarily involve change in genotype. Since 40s epigenetics became the topic of interest among the scientific community. Now everybody wants to know that what goes on beyond the DNA and majority says that only epigenetics can address this question....

 Open Access DOI:10.23937/2474-3631/1510006

Alcohol Withdrawal Syndrome: The Importance of Glutamatergic System

Jose Carlos F. Galduroz, Pedro Luis Prior and Anna Carolina Ramos

Article Type: Editorial | First Published: July 30, 2015

Alcohol withdrawal syndrome (AWS) is a complex phenomenon that involves several neurotransmission systems. Its signs and symptoms are related to the adrenergic autonomic hyperstimulation and to the hypofunction of the gabaergic system. Moreover, alcohol is an antagonist of the NMDA (N-Methyl-D-Aspartate) receptors, which are excitatory, in the central nervous system....

 Open Access DOI:10.23937/2469-5807/1510005

Flow Cytometric Analysis of Cell Size in B-Cell Non-Hodgkin Lymphoma: Reliability and Potential Diagnostic Significance

Aaron Cotrell, Farzaneh Sayedian, Michelle Huang, Xia Chen, Ming Xie, Marc Smith and James Huang

Article Type: Research Article | First Published: July 13, 2015

Evaluation of lymphoma cell size is a key step in the sub classification of B-cell lymphomas. Lymphoma cells can be classified as large, small or (less commonly) medium; but recognition of large B-cells is of particular importance because of their diagnostic and prognostic significance. Lymphomas with increased large cells are often associated with more aggressive clinical course. For instance, neoplastic B-cells of diffuse large B-cell lymphoma (DLBCL) are predominately large cells....

 Open Access DOI:10.23937/2474-3674/1510001

Protocols for Uncontrolled Donation after Circulatory Death: International & Comprehensive Analysis

Ivan Ortega Deballon

Article Type: Editorial | First Published: July 18, 2015

Determination of death, the exact moment that a person's death occurs, has been a constant challenge throughout human being history. What we already know is that death usually does not occur abruptly, at a specific time and for all parts of the body simultaneously. Human resistance to degradation by lack of oxygen varies depending on the type of cell and organ. It is possible, for example, for successful cornea transplants from deceased individuals as many as seven days after death. Actually, the absolute absence of any residual vital activity in the body after cessation of circulatory functio...

 Open Access DOI:10.23937/2377-3634/1410035

The Relationship between Diabetes and Retirement from Work: A Ten Year Follow-Up in National Registers

Bryan Cleal and Kjeld Poulsen

Article Type: Research Article | First Published: July 22, 2015

Objectives: To investigate the relationship between diabetes, mortality and exit from work using various Danish Pension schemes. Methods: We linked the Danish National Diabetes register with socioeconomic and population-based registers and followed prevalent and incident cases of diabetes for ten years, adjusting for gender, age and socio-occupational group. We analysed the proportion of individuals with diagnosed diabetes before and after entering a normal retirement pen-sion, voluntary early retirement pension or disability pension. Risk ratios for entering pensions, emigration and mortali-t...

 Open Access DOI:10.23937/2474-3690/1510001

Review of 2003 to 2015 Guidelines on Treatment of Hypertension in Patients with Coronary Artery Disease

Wilbert S. Aronow

Article Type: Review Article | First Published: July 18, 2015

Patients with coronary artery disease should have their modifiable coronary risk factors intensively treated. Dietary sodium should be reduced. Hypertension should be treated with beta blockers and angiotensin-converting enzyme inhibitors or angiotensin receptor blockers. Long-acting nitrates are effective antianginal and antiischemic drugs. Calcium channel blockers may be added if angina persists despite beta blockers and long-acting nitrates....

 Open Access DOI:10.23937/2378-3419/2/3/1018

A Simple Two-Stage PCR Method for Quality Amplification of Degenerate DNA

Ebili Henry O, Ham-Karim Hersh Abdul and Ilyas Mohammad

Article Type: Original Article | First Published: July 06, 2015

Formalin-fixed, paraffin-embedded (FFPE) tissue banks are invaluable to cancer genetics and biomarker discovery. However, FFPE tissue-derived DNA is degenerate. As such, any PCR technique which will give adequate amplification of such DNA to enable downstream applications is important to the characterization of genetic biomarkers and to personalized medicine. The aim of this article is to describe a two-stage PCR method which efficiently amplifies degenerate FFPE tissue-derived DNA. Amplicon enriched templates were produced by a fist-stage multiplex PCR which used fie or more primer pairs with...

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