Some Diagnostic Aspect on Abnormal Nitric Oxide Metabolism and Some Pharmacological Aspects of the most used Drugs in Rheumatoid Arthritis
Article Type: Research Article | First Published: July 31, 2015
Introduction: To evaluate the diagnostic test for Assymetric Dimethyl Arginine (ADMA), Rheumatoid factor (RF), C-reactive protein (CRP), Disease Activity Score with 28 joint ( DAS 28 index ), and to define the effect of untreated rheumatoid arthritis on endothelial function. In order to determine whether ADMA changes depending on the disease evolution, ADMA was used as an indicator for endothelial dysfunction in subclinical atherosclerosis Methods: Using a ELISA technology of DLD-Diagnostika-GMBH for detection of ADMA, the samples of serum and urine have been examined in 70 participants (35 RA...
The Case of 11w+ 2d Fetal Heart Rate Positive Unruptured Cervical Pregnancy
Onder Sakin, Bulent Kars, Ilke Tanir and Omer Talip Turhan
Article Type: Case Report | First Published: August 05, 2015
The treatment of cervical pregnancy which is one of the rarest forms of ectopic pregnancy is one of the cases difficult decisions need to be taken. Many years ago when hysterectomy was the only treatment and in case of late treatment decision, 50% of maternal mortality was seen, which results in a change of status with the shape of the high-risk pregnancies' extremely minimal invasive treatment may be possible Moreover, the patient fertility will be preserved and hysterectomy and the negative situations accordingly will stay away....
Spontaneous Ruptured Heterotopic Fallopian Tube Pregnancy: A Challenging Case
Olga Grechukhina, Diana P. English, Wei Hong, Ravi Kaza and Elena Ratner
Article Type: Case Report | First Published: August 09, 2015
This is a case of a 39 year old gravida 4 para 2-0-1-2 patient who presented to the emergency room with 1 week history of worsening left sided abdominal pain associated with vaginal bleeding. She had a positive pregnancy test and transvaginal ultrasound demonstrated an 11x9x7cm retrouterine mass concerning for hemorrhagic debris but no adnexa were identified. Surgery was complicated by conversion from laparoscopy to low transverse laparotomy due to hemorrhage and severe adhesive disease. Both tubes were dilated with evidence of ectopic pregnancy. A bilateral salpingostomy was performed and the...
Discharge Care Bundle for Patients with Acute Exacerbations of COPD: Benefit more likely to be seen beyond 30 Days
Shorofsky M, Lebel M, Sedeno M, Zhi Li P and Bourbeau J
Article Type: Original Article | First Published: August 03, 2015
Background: COPD is associated with significant morbidity, mortality, and hospital costs. The implementation of COPD 'discharge care bundles' has been proposed as having an impact on readmissions. We developed and implemented a discharge care bundle and the aim of this study was to evaluate its effects on utilization of hospital services in a real life setting. Methods: We conducted a retrospective chart review study from 2007-2013 to evaluate utilization of hospital services over three time periods (30, 90 days, and one year) post discharge care bundle implementation in two patient cohorts. T...
Ethical Issues Surrounding In-Patient Treatment for Adolescents with Substance Use Disorders
Article Type: Review Article | First Published: August 12, 2015
The following article reviews the literature on ethical issues surrounding in-patient treatment of adolescents with substance use disorders. Ethical issues surrounding confidentiality, informed consent, competency, multiple relationships and boundaries, working on a multi-disciplinary team, responsible caring, and termination of services are discussed. There is a gap in the literature regarding the ethical issues associated with this specific population; however, given the sensitive nature of this population and treatment setting, knowledge and understanding of these ethical issues are critica...
Ocular Hypotensive Activity of a Non-Peptide Bradykinin B2-Receptor Antagonist (WIN-64338) In Dutch-Belt Rabbits- A Case of Poly-Pharmacology in Action
Najam A Sharif, Laura Klekar, Linya Li and Shouxi Xu
Article Type: Research Article | First Published: August 11, 2015
Ocular hypertension is a well-recognized and treatable biomarker that is believed to be involved in the etiology of primary open-angle glaucoma, the second leading cause of blindness in the world. This retinopathy is a painless disease that is slow but progressive and steals the patient's sight if left untreated. Over the last several decades, a number of pharmaceutical agents have been shown to be effective in reducing intraocular pressure (IOP) and have been approved for treatment of glaucoma and the associated elevated IOP. Thus, muscarinic agonists, beta-blockers, alpha-2 agonists, carboni...
A Surgical Procedure and Prognosis for Gallbladder Carcinoma According to the Extent of the Tumor Invasion-A Retrospective Case Series Study at a Japanese Hospital
Akitsugu Makino, Hiroshi Nakagomi, Atsushi Takano, Masahiro Maruyama, Kazunori Takahashi, Yuko Nakayama, Masayuki Inoue, Kazushige Furuya, Hidemitsu Sugai, Masao Hada, Yoshiaki Miyasaka and Toshio Oyama
Article Type: Case Series | First Published: August 14, 2015
Purpose: To analyze the prognostic effects of our selecting surgical procedures for gallbladder carcinoma based on the extent of tumor invasion. Methods: We reviewed 35 patients with gallbladder carcinoma who underwent the surgical treatment in our hospital. We divided the patients into three groups (8 with T1, 15 with T2, and 12 patients with T3) according to the pathological extent of the tumor invasion. Results: Although 8 patients with T1 group had been achieved curative operation (R0), 2 patients developed an unexpected recurrence regardless the kinds of surgical procedures....
Left Renal Cell Carcinoma with a Tumor Thrombus in the Inferior Vena Cava: A Case Report
Changqin Jiang and Chaozhao Liang
Article Type: Case Report | First Published: July 30, 2015
A case of Left renal cell carcinoma with a tumor thrombus in the inferior vena cava in a 79-years-old woman is presented. Renal Cell Carcinoma (RCCs) is the most common malignancy of the kidney. Because of shorter right renal vein, the right renal cell carcinoma is more common, the cases of left renal cell carcinoma merging inferior vena cava cancer embolus were rare compared to those in the right. Here, we reported a case is with left renal cell carcinoma with a tumor thrombus in the inferior vena cava....
Chorioretinitis as a Rare Presentation of Cat Scratch Disease: A Case Report
Zimmermann, Nicolas Lefebvre, Jaulhac B and Sauer A
Article Type: Case Report | First Published: July 30, 2015
A 12-year-old female was referred in our center for management of a chorioretinopathy. Ophthalmologic examination revealed unilateral chorioretinal scar with subretinal detachment. Laboratory evaluation revealed IgG antibodies for Bartonella hensalae. Treatment with oral azithromycin led to regression of lesions, resolution of subretinal detachment, and improvement in visual acuity....
Modified Vertico-Sagittal Osteotomy Technique
Renato de Toledo Breguez, Giovanni Gasperini and Jose Nazareno Gil
Article Type: Review Article | First Published: July 29, 2015
Among the techniques used to correct mandibular deformities, intraoral vertico-sagittal ramus osteotomy is indicated for small mandibular rotations and forward or backward movements. Although it is still little used by oral and maxillofacial surgeons, it presents advantages compared to intraoral vertical ramus osteotomy because of a greater contact between bone fragments, and in relation to sagittal split ramus osteotomy, it introduces a parallelism to the sagittal plane, thereby decreasing the possibility of a post-operative dislocation of the mandibular condyle and leading to a lower inciden...