Qualitative Research: A pathway to Gain an Understanding of UAE Mothers' experiences and Perceptions of Managing a Child Newly Diagnosed with Type 1 Diabetes
Jennifer Louise Cooper, Suhad Marjei, Rachel Rossiter and Sharon Brownie
Article Type: Research Article | First Published: November 25, 2014
A childhood diagnosis of Type 1 diabetes is a life changing event for both the child and his/her family. The impact is experienced strongly by mothers who most frequently fulfil the primary caregiver role for children12 yrs old and younger. Studies which have sought to understand mothers' experiences and perceptions of managing a child newly diagnosed with Type 1 diabetes are mostly questionnaire-based and few, if any, explore the issues within the uniqueness of a Middle-Eastern context. The qualitative research methods described in this discussion have been designed to gain a better understan...
Randomised Clinical Trial Comparing the Efficacy of A Gluten-Free Diet Versus A Regular Diet in A Series of Relapsing-Remitting Multiple Sclerosis Patients
Rodrigo L, Hernandez-Lahoz C, Fuentes D, Mauri G, Alvarez N, Vega J and Gonzalez S
Article Type: Original Article | First Published: December 08, 2014
Objectives: To analyse the clinical efficacy of a Gluten-Free Diet (GFD) compared with a Regular Diet (RD) in Relapsing-Remitting Multiple Sclerosis (RRMS) patients.
Methods: Seventy-two RRMS patients were included into a prospective study. Annual relapse rate (ARR), Expanded Disability Status Scale (EDSS) and lesional activity were compared. Patients were randomly separated according to diet: (GFD, n=36) and (RD, n=36). Follow-up study period was 5.3 ± 1.6 years (median 4.5 years).
Results: At the end of the study period, a clear improvement in the EDSS was observed in GFD (1.5 ± 1.4) com...
D-Leucine Suppresses Prion Formation in Prion-Infected Culture Cells
Kana Miyashita, Morika Suzuki, Kana Nishijima and Naomi Hachiya
Article Type: Short Communication | First Published: November 24, 2014
Prion disease is an infectious and fatal disease. The pathogen consists of an abnormal form of the prion protein; designated PrPSc. PrPSc is insoluble, highly resistant to digestion by proteases and all disinfectants. In contrast, the cellular form of prion protein PrPC is easily soluble and digested by proteases. Direct interaction between PrPSc and PrPC is believed to induce the propagation of prions; however, the molecular mechanisms underlying this step have not been clarified. Despite efforts to find molecules that can specifically interact with the prion protein conformer and thereby inh...
Variation H452Y in HTR2A Gene Effects Immediate Visual Memory
Nesli Avgan, Heidi G. Sutherland, Lauren K. Spriggens, Astrid J. Rodriguez-Acevedo, Larisa M. Haupt, David H. K. Shum and Lyn R. Griffihs
Article Type: Research Article | First Published: November 12, 2014
Serotonin and its receptors, including the 5-Hydroxytryptamine Receptor 2A encoded by the HTR2A gene, are important for learning and memory in animals and humans.Polymorphic variation in the HTR2A gene, which encodes the 5-HT2Aserotonin receptor, has previously been shown to associate with some memory traits,in particular effecting delayed verbal memory. In the current study we have examined the HTR2A His452Tyr (H452Y) substitution for association in a cohort of healthy individuals whose memory traits were assessed using a comprehensive battery of memory tests including, but not limited to, me...
Modification of Antiretroviral Therapy in a Cohort Study of HIV-Infected Patients Attending an Urban Teaching Hospital in Kenya
AO Owuor, GN Lule, CF Otieno, EO Omonge, MC Maritim and P Memiah
Article Type: Research Article | First Published: November 28, 2014
Objective: To determine the prevalence and factors associated with ART modification among HIV patients on 1st line therapy attending a large Teaching Hospital in Kenya.
Methods: A retrospective cross-sectional clinical record review. All patients who commenced ART from January 2005 to June 2011 and had at least 1 follow-up visit were evaluated. Baseline data, including socio demographic and clinical variables was collected using a standard chart abstraction tool.
Results: Out of 1,022 patients 658 (64.4%) were female and the mean age of study participants was 37.8years. The median CD4+ cou...
Prognostic Value of Some Acute Phase Reactants in the Management of Pulmonary Tuberculosis Disease
Akpotuzor Josephine O, Ekarika Evelyn A and Akwiwu Euphoria C
Article Type: Research Article | First Published: November 16, 2014
This study was conducted to assess the relevance of serum C- reactive protein (CRP), erythrocyte sedimentation rate (ESR), relative plasma viscosity (RPV) and fibrinogen level in the management of pulmonary tuberculosis (PTB) disease. One hundred (100) PTB patients attending the TB clinic of Dr Lawrence Henshaw Memorial Specialist Hospital Calabar, and 70 age and sex-matched apparently healthy subjects between 15-65 years of age were selected and enrolled. Standard techniques were used for the assays. Results showed significantly lower PCV (p<0.05) in PTB patients (0.35 ± 0.07L/L) when compare...
Identification of Ten Novel Mutations in Factor VIII Gene: A Study of A Cohort of 52 Haemophilia A Patients
Rosa Santacroce, Angelica Leccese, Roberta Trunzo, Giuseppe Lassandro, Paola Giordano, Cosimo Ettorre, Stefano Antoncecchi, Isabella Cantori, Alfredo Dragani, Donata Belvini, Roberta Salviato and Maurizio Margaglione
Article Type: Research Article | First Published: October 14, 2014
Introduction: Haemophilia A (HA) is the most common X-linked recessive genetic disease caused by mutations in the gene coding for coagulation factor VIII (FVIII) resulting in spontaneous bleeding.
Aim: The aim of our study is to provide additional information about the genetic causes of HA describing the correlation between the observed mutations and the clinical phenotype in a cohort of 52 patients suffering from HA to different degrees.
Methods: First we performed a search of inversion 22 (IVS22) and of the intron 1 (IVS1) for severe HA patients; inversions negative and moderate/mild HA ...
Allergy to General Anesthetics: Evaluation of Patients Profile
Carla Irani, C. Saade, C. Dagher and P.Yazbeck
Article Type: Original Article | First Published: November 02, 2014
8 millions procedures requiring anesthesia are performed yearly in France with 75% of them being general anesthesia. In 45% of those procedures, a NMBA (neuromuscular blocking agents) is used. Th incidence of allergy to general anesthetics ranges between 1/20000 in Australia and 1/350 in Great-Britain. Th incidence of peranesthestic allergic reactions estimated in 1996 in France was 1/9000, all drugs confounded and the incidence of allergic reactions to NMBA was evaluated to be 1/6500 anesthesia. Allergic reactions can be benign or fatal in some cases (6%), presenting with urticaria /angioedem...
Assessment of Learning Guides Improvement in Diabetes Education Program: A QI Initiative for Type I Diabetes Mellitus in Children and Adolescents
Manmohan K. Kamboj, Kathryn J. Stephens, Richard J. Brilli, Heather L. Yardley, Jeff Lewis, Richard E. McClead, Jr. and David R. Repaske
Article Type: Research Article | First Published: November 17, 2014
Aims: To develop objective assessment tools to evaluate proficiency of well-day (WD) and sick-day (SD) diabetes knowledge and management skills in families of pediatric type 1 diabetes patients and to utilize this information to modify our diabetes education (DE) program to improve learning of the desired knowledge and skills.
Methods: Vignette-based assessment quizzes were developed to evaluate WD and SD diabetes knowledge and management skills. Vignettes assessed basic knowledge and skills including calculation of insulin doses, treatment of hypoglycemia, and management of hyperglycemia an...
Type 2 Diabetes and Lifestyle- A Prospective Population-Based Cohort Study among Rural Men
Anders Thelin and Sara Holmberg
Article Type: Research Article | First Published: November 16, 2014
The risk of type 2 diabetes (T2D) is related to lifestyle but less is known about how lifestyle factors interact and how they impact the risk when combined. This study was performed to analyze how lifestyle factors relate to the cumulative incidence of T2D in a Swedish rural population. Outcomes were generated from national registers and from two surveys. Two hundred sixty men (11%) with diabetes were found in the registers, and 193 men with T2D were identified in the surveyed population (9.8%). Physical activity (OR for high physical activity=0.55 (95% CI 0.31-0.97) and meal quality (OR for h...