ClinMed International Library

The ClinMed International Library is a repository and an open access publisher for medical research that covers a wide range of areas in Clinical Medicine. ClinMed serves as a global platform for medical practitioners and research scholars to foster their learning and professional acumen through an extensive portfolio of research articles and publications that can be accessed without any restrictions.

Dedicated to clinical medical research, we now publish over 70 quality peer-reviewed journals making all the articles freely accessible. The manuscripts submitted to ClinMed will be processed through standard parameters and international peer review systems. This has enabled us to establish new milestones in the global research arena in terms of cogency and integrity, and to disseminate highly credible and accredited research content for researchers, scholars, and practitioners across the globe.

We ensure that all researchers and authors publishing their papers with us retain copyrights, licensed under Creative Commons Attribution License that permits the unrestricted use and re-use of the content with proper citation.

ClinMed International Library

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Articles Published

All articles are fully peer reviewed, free to access and can be downloaded from our ClinMed archive.

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 Open Access DOI:10.23937/2378-3656/1410012

Monitoring of the Left Recurrent Laryngeal Nerve during Mediastinoscopy is Feasible and Safe

Wolfram Karenovics, Sebastien Guigard, Besa Zenelaj, Marc Licker and Frederic Triponez

Article Type: Research Article | First Published: December 29, 2014

Objective: Left Recurrent Laryngeal Nerve (RLN) palsy is a well known complication of cervical mediastinoscopy and is not infrequent if specifically looked for. Electro-physiological monitoring of the RLN is common practice in thyroid surgery and has greatly improved outcomes. We applied the same technique during cervical video-mediastinoscopy. Patients and methods: Between October 2012 and October 2013 patients undergoing mediastinoscopy were enrolled prospectively for intra-operative monitoring of the left RLN. A standardized protocol for the use of the neuromonitor was followed....

 Open Access DOI:10.23937/2378-3648/1410011

Relationship of Mitochondrial DNA Haplogroups with Complex Diseases

Carlos G Urzua-Traslavina, Maria G Moreno-Trevino, Denisse A Martinez-Trevino, Hugo A Barrera-Saldana and Rafael BR Leon-Cachon

Article Type: Review Article | First Published: December 16, 2014

Mitochondria are responsible for energy production in unicellular and multicellular eukaryotes. Apart from their major role in metabolism, mitochondria are involved in many other cellular processes. A new paradigm is needed to understand aging, aging-related illnesses, and complex diseases. Because of the long co-evolution of mitochondria with the cells, subtle variations in the function of these organelles could influence many organ systems. Understanding the extent of this influence will shed light on the pathophysiology of some of these diseases. This review will examine the history of mito...

 Open Access DOI:10.23937/2378-3648/1410010

Oxidative Stress and the Epigenome in Human Disease

Adriana Arita and Max Costa

Article Type: Review Article | First Published: December 15, 2014

Epigenetics refers to the study of the changes in gene expression that occur without changes in the DNA sequence. There is growing evidence that epigenetic modifications such as changes in the levels of DNA methylation or post-translational histone modifications are involved in the pathogenesis of many human diseases including cancer. Oxidative stress as a result of metabolic or environmental factors leads to excessive production of reactive oxygen species (ROS). ROS plays a role in many human diseases including cancer and pulmonary and cardiovascular diseases by promoting DNA damage and/or al...

 Open Access DOI:10.23937/2378-3648/1410009

Discordant Disease Course in a Monozygotic Twin Pair with Juvenile Myelomonocytic Leukemia

Silvia Bresolin, Paola De Filippi, Claudia Cagioni, Simone Cesaro, Annamaria Di Meglio, Anna Leszl, Fiorenza Aprili, Chiara Cugno, Chiara Frasson, Marco Zecca, Cesare Danesino and Geertruyte Kronnie

Article Type: Research Article | First Published: December 14, 2014

Juvenile myelomonocytic leukemia is a rare neoplastic disorder occurring in early childhood often showing an aggressive progression. We report a case of a twin pair with concordant JMML but an extremely different disease course. Both twins presented with somatic aberrations of chromosome 7 and mutations in PTPN11. Analysis of sorted BM and PB cell populations revealed the clonal nature of the disease and indicated that genomic aberrations arise from common hematopoietic precursor cells. PTPN11 mutations in oral swab specimens of both patients during the active phase of the disease were attribu...

 Open Access DOI:10.23937/2378-3516/1410007

Eicosapentaenoic Acid Decreases Histamine Receptor 1 Expression on Lung Microvascular Endothelial Cells and Cell Permeability during LPS Stimulation

Takaaki Osako, Michiko Aoyama-Ishikawa, Hayato Yamashita, Makoto Usami, Atsunori Nakao and Joji Kotani

Article Type: Original Article | First Published: December 26, 2014

Introduction: During acute lung inflammation, the lung microvasculature becomes hyperpermeable, resulting in immune cell infiltration and tissue edema. N-3 polyunsaturated fatty acids (PUFAs), when used as a supplement in parenteral nutrition, can attenuate Lipopolysaccharide (LPS)-induced lung injury. In this study, we examined the effects n-3 PUFAs on lung microvascular cell permeability. Material and methods: Human lung microvascular endothelial cells (HMVEC-L) were seeded on fibronectin-coated transwell inserts. The cells were pretreated with docosahexaenoic acid (DHA) or eicosapentaenoic ...

 Open Access DOI:10.23937/2378-3516/1410006

Infective Endarteritis in a Patent Ductus Arteriosus

John Fani Srour

Article Type: Case Report | First Published: December 15, 2014

The ductus arteriosus, an essential fetal structure, normally closes spontaneously soon after birth. It's persistence into late adulthood is considered rare; infective endarteritis complicating a patent ductus arteriosus (PDA) is an even rarer event. The clinical picture of an infected PDA could be subtle, and the diagnosis is frequently delayed. Symptoms may well be attributed to community acquired pneumonia, pleurisy, or pulmonary infarction from pulmonary embolism. Occasionally, especially in the case of silent PDA, the correct diagnosis can be reached after an extensive work up of fever of...

 Open Access DOI:10.23937/2378-3664/1410006

Optimization and Validation of a New Method for the Production of Lipid Nanoparticles for Ophthalmic Application

Rosario Pignatello, Antonio Leonardi and Sarha Cupri

Article Type: Research Article | First Published: December 29, 2014

Within a wider research project aimed at the pre-industrial development of nanotechnology platforms for the treatment of eye diseases, this work exploited the possibility of obtaining solid lipid nanocarriers (SLN) using ingredients and operating conditions that could be compatible with the technological requirements of medical formulations used for ophthalmic therapies and, above all, capable of an easy industrial scale-up....

 Open Access DOI:10.23937/2378-3664/1410005

Development of A Cellular Hepatocarcinoma Animal Model for the Evaluation of Pt(Acac)2/Tio2 Nanoparticles Effect

Tessy Lopez Goerne, Mayra Alvarez Lemus, Gustavo Jardon Guadarrama, Paola Ramirez Olivares, Aurora Sanchez Garcia, Daniel Rembao Bojorquez, Ruben Arguero Sanchez and Octavio Novaro Penalosa

Article Type: Research Article | First Published: December 16, 2014

Because of the worldwide increasing incidence of cancer new alternative therapies are needed. The use of nanotechnology for clinical applications is constantly growing. The objective of this work was to evaluate the effect of the administration of platinum inorganic nanoparticles over livers from Wistar rats. In order to reach this goal cellular Hepatocarcinoma was fist induced with N-nitrosodiethylamine (NDEA) and Carbon tetrachloride....

 Open Access DOI:10.23937/2377-4630/1/3/1018

Time and Motion Study Assessment of Simulated Rapid Sequence Intubation

Trung Du, David Bramley, Justin Nazareth and David T Andrews

Article Type: Research Article | First Published: December 29, 2014

We carried out an observational study using a system of time and motion analysis that was developed to critically evaluate work systems by correlating the number and type of hand and equipment movements that were associated with the time taken to perform the stereotypical anaesthetic technique of rapid sequence intubation (RSI). The number and type of hand movements required to complete RSI exhibited significant correlation with, and were linearly related to, the time taken to carry out the RSI procedure....

 Open Access DOI:10.23937/2377-4630/1/3/1017

Robotic Surgery, Hypertrophic Cardiomyopathy and Difficult Airway - A Challenging Combination for the Anesthesiologist! : A Case Report

Uma Hariharan, Shagun Bhatia Shah and Binod Kumar Naithani

Article Type: Case Report | First Published: December 23, 2014

The introduction of robotic surgery has heralded new challenges for the anesthesiologists. The daVinci TM robotic system provides a three-dimensional view and better work ergonomics for the surgeon, especially in complex and radical cancer surgeries. Innovation of robotic surgery has opened the doors for newer concerns in patient safety for the anesthesia team. This is of greater importance in patients with concurrent serious conditions like hypertrophic cardiomyopathy. The challenge becomes greater when difficult airway compounds the situation....

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