Intervention for Non-verbal and Minimally-Verbal Individuals with Autism: A Systematic Review
Lynn Kern Koegel, PhD, Katherine M Bryan, BA, Pumpki Su, MA, Mohini Vaidya and Stephen Camarata, PhD
Article Type: Review Article | First Published: September 27, 2019
Most children diagnosed with ASD will present with late onset verbal communication, and at least one third of these children will remain minimally or completely nonverbal throughout their lifespan, speaking few or no words. Challenges with verbal language can negatively affect many areas, including socialization, academics, independent living and employment. The objective of this paper was to systematically review interventions for the treatment of nonverbal and minimally verbal individuals with ASD. This review exclusively selected studies that targeted verbal communication in minimally and n...
Mathematical Hegselmann-Krause (HK) Model Predicts Chemotherapeutic Resistance to Cisplatin in Human Cervical Cancer Cell Lines
John Zihou Chen, Rong Wu, Henry Simpkins, Zhendong Sun and Jianli Chen
Article Type: Original Research Article | First Published: September 25, 2019
Solid tumors usually have a complex cellular components and intercellular interactions in a complex tumor microenvironment. We used a mathematical HK model to predict the change of drug resistance to cisplatin in a mixed sensitive and resistant human cervical cancer cell population and then employed a cytosensitivity assay to evaluate if biological findings could confirm this change predicted by HK model. We used the HK model to predict the resistance to cisplatin in the mixed cell population. To confirm this prediction, we mixed the sensitive and resistant cancer cells and studied their resis...
A Mathematical Method to Easily and Accurately Measure the Tumor Volume of Prostate Cancer on Pathological Slides
John Zihou Chen, Monika Wrzolek, Lynne Opitz and Jianli Chen
Article Type: Original Research Article | First Published: September 21, 2019
For decades, it has been a big challenge to directly and accurately measure an irregularly shaped area for a tumor volume evaluation of prostate cancer. All current methods are not ideal for different reasons. An objective, practical, accurate, and reliable method for measuring of prostate cancer volume is needed, in particular in modern precision medicine setting, pursuing accuracy and quality of health care. In this study, we applied a mathematical method - the Gauss area calculation formula to the evaluation of irregular shape of prostate cancer areas on H&E slides. To simplify the calculat...
Neuromodulation for Drug-Refractory Epilepsy and Chronic Heart Failure: Targets, Delivery, Composition and Titration
Inder S Anand, MD, FRCP, DPhil (Oxon), Marvin A Konstam, MD, Jeffrey L Ardel, PhD3, Imad Libbus, PhD, Lorenzo A DiCarlo, MD and Douglas L Mann, MD
Article Type: Original Articl e | First Published: September 23, 2019
Vagus nerve stimulation (VNS) is used currently in the management of drug-refractory epilepsy (DRE), and is in development for treating chronic heart failure (HF). HF is accompanied by autonomic nervous system (ANS) dysfunction, consisting of sustained sympathetic hyper-activation and withdrawal of parasympathetic tone, and associated with progressive worsening of cardiovascular (CV) function and increased morbidity and m ortality. We sought to compare how VNS is utilized for DRE and may potentially be employed for HF. Neuromodulation for the treatment of epilepsy and HF is not a one-size-fits...
Diabetes in Latin America: Prevalence, Complications, and Socio- Economic Impact
L Sinisterra-Loaiza, A Cardelle-Cobas, AG Abraham, MN Calderon, MA Espinoza, LG Gonzalez- Olivares, M Gotteland, A Pazos-Sierra, S San Martin, A Cepeda, JJ Gagliardino and IBEROBDIA Project Group
Article Type: Research Article | First Published: September 28, 2019
To review and update epidemiological data on type 2 diabetes (T2D) in Spain and four Latin American countries: Colombia, Mexico, Chile, and Argentina. Literature was reviewed by a search of PubMed, publications of the Ministry of Health, World Health Organization, International Diabetes Federation, and other public health agencies of each respective country. Of the five countries above, Mexico (13.6%) had the highest prevalence of diabetes, followed by Spain (10.4%). Within these countries, significant differences between urban and rural areas were observed (7.8% and 1.4%, respectively). Diabe...
The Role of Human Papillomavirus in Cervical Cancer
Beata Smolarz, Dariusz Samulak, Marianna Makowska, Hanna Romanowicz, Zbigniew Kojs, Luiza Wojcik and Magdalena M Michalska
Article Type: Review Article | First Published: September 28, 2019
Long-term infection with human papillomavirus (HPV) is the cause of cervical cancer and its precursor - cervical intraepithelial neoplasia (CIN). The presence of HPV infection can be presumed in more than 99% of cases of cervical cancer worldwide. The introduction of DNA testing for the presence of HPV has increased the effectiveness of screening programs for the detection of this cancer. This article contains the latest reports on the structure, function and role of HPV in the development of cervical cancer. It was also underlined the importance of performing molecular tests for the presence ...
Social Influences of Teachers, Classmates, and Parents on Children's Commitment to Physical Education and Language Education
Derwin KC Chan, Karen CH Lo and Felix Cheung
Article Type: Research Article | First Published: September 30, 2019
This study aims to examine the social influences of teachers, classmates and parents (i.e., positive reinforcement and punishment) on childrens commitment to physical education (PE) and language education (LE). Children from the UK (N = 614; Mean age = 13.05, SD = 2.01) completed the Perceived Social Influence Scale (Chan, et al. 2012), and also measures of competence, enjoyment, and effort in either the PE or LE context. Multi-group structural equation modelling (CFI = 0.97-0.98; TLI = 0.96-0.97; RMSEA = 0.03-0.04) showed that social influences from teachers, classmates, and parents explained...
Working through Others - A Qualitative Content Analysis of Nursing Students’ Experiences with Malnutrition at One Hospital in Vietnam
Elin Eriksson, RN, BSc, Victoria Ferm, RN, BSc and Kristina Rosengren, PhD, RN
Article Type: Original Article | First Published: October 05, 2019
Malnutrition causes problems in Vietnam, including illnesses with physiological and psychological complications. The aim of this study was to describe nursing students experiences with malnutrition at one hospital in Vietnam. Interviews of eight nursing students were performed, and the results were analysed by qualitative content analysis. This study highlights the use of guidelines in collaboration (between staff and patients’ relatives) to facilitate early identification and/or prevent malnutrition by improving self-care, as supported through nursing activities using family-centred care as...
Saphenous Vein Graft Aneurysm and Coronary Artery Disease: Case Report
Victor Rodrigues Ribeiro Ferreira, Maria Christiane Valeria Braga Braile-Sternieri, Eliana Migliorini Mustafa, Giovanni Braile Sternieri, Sofia Braile Sabino, Cibele Olegário Vianna Queiroz, Bethina Canaroli Sbardellini, Luiza Braile Verdi, Idiberto José Zotarelli Filho and Domingo Marcolino Braile
Article Type: Case Report | First Published: September 28, 2019
Despite a general reduction in the number of myocardial revascularization surgeries in recent decades, more than 150,000 are still performed annually in the United States. Early complications of venous graft use include an occlusion rate of up to 25% in the first year. The aneurysmal dilatation of the great saphenous vein, when used in aorto- coronary venous bridges, is rare and requires important care by the cardiology team. This study aimed to present a case report on saphenous vein aneurysm in a patient with coronary artery disease and myocardial ischemia who was diagnosed by angiotomograph...