An Unexpected Operative Finding of Intracerebral Pus in a Case of Multifocal Cerebral Metastases from Small Cell Lung Cancer
Ibiwari Pepple and Debasish Hajra
Article Type: Case Report | First Published: October 05, 2019
Small cell lung cancer (SCLC) accounts for 10-20% of all lung cancers and is characterised by early and rapid spread. Ten percent of patients already have cerebral metastases at time of presentation. We report a case of a 37-yr-old female whose pre-operative CT and MRI brain revealed multicentric left frontal and temporal lesions which mimicked intracerebral abscess intraoperatively and confirmed on gram stain as moderate growth of white cells. The patient was commenced on prolonged antimicrobial therapy postoperatively, however, histology reported SCLC metastases with lung as primary and pati...
Vancomycin-Resistant Staphylococcus aureus: Formidable Threat or Silence before the Storm?
Helen Kest and Ashlesha Kaushik
Article Type: Review Article | First Published: September 21, 2019
Globally, Staphylococcus aureus (S. aureus), notably methicillin-resistant S. aureus, is a leading cause of morbidity and mortality. Vancomycin is considered a drug of last resort for severe MRSA and other resistant Gram-positive infections. Vancomycin enjoyed a high level of success for decades following MRSA outbreaks until recent reports of increasing S. aureus MICs culminating in high-level vancomycin-resistant S. aureus (VRSA), first reported in 2002. Since then, there have been selected case reports of VRSA disease in the US and other countries. The resistance mechanism of VRSA is mediat...
White Coat Hypertension in Children and Adolescents: Innocent or Not?
Evrim Kargin Cakici, Eda Didem Kurt Sukur, Fatma Yazilitaş, Gokce Gur, Tulin Gungor, Evra Celikkaya, Deniz Karakaya and Mehmet Bulbul
Article Type: Research Article | First Published: September 30, 2019
The clinical significance of white coat hypertension is still uncertain. We aimed to evaluate children with white coat hypertension regarding their clinical, laboratory characteristics, evidence of target organ damage and compare them to normotensive and hypertensive children. Fourty patients diagnosed with white coat hypertension, 40 patients with primary hypertension and 40 normotensive children of similar age, gender and body mass index were included in the study. Ambulatory blood pressure monitoring and echocardiographic examination were performed to all children. Clinical and laboratory c...
Partial Endoprosthesis Application with Posterior Mini-Incision in Geriatric Hip Fractures: A Retrospective Study
Recep Dincer, Halil Burc, Y Barbaros Baykal, Tolga Atay and Vecihi Kirdemir
Article Type: Research Article | First Published: October 03, 2019
Recent technological advancements and accumulating surgical experience have led to a higher interest in orthopedic minimally invasive surgery. This study aims to present the feasibility of posterior mini-incision for partial hip prosthesis compared with total hip prosthesis. In all patients, a mini-incision of 8.5-cm mean length was used. The mean surgical duration was 67.4 min, and the mean blood loss was 526 mL. We observed no neurovascular damage in any patient resulting from the limited exposure. Moreover, no postoperative complication was reported, and there was no mortality during the fo...
Two Rare Mechanisms for Acute Anuric Renal Failure in a Patient with Metastatic Malignant Melanoma - A Case Report
Amy D Kennedy, MD, Alex J Liu, MD, Regan M Seipp, MD, Margaret S Ryan, MD, Shaun K Yang, MD, MPH and Leslie F Thomas, MD
Article Type: Case Report | First Published: September 27, 2019
This case report examines two rare mechanisms of acute renal failure in a patient with metastatic melanoma treated with high-dose vitamin C. The first is oxalate nephropathy, which is an uncommon but known complication of highdose vitamin C therapy in naturopathic medicine. The second is due to melanuria and renal melanosis, which has been described in metastatic melanoma; however, acute renal failure requiring renal replacement therapy has not been reported previously. We report a patient with metastatic melanoma who presented to our hospital in acute anuric renal failure after receiving natu...
Prevalence, Etiology and Clinical Characteristics of Biopsy Proven Non-Diabetic Renal Disease in a Population of 67 Diabetic Patients
Joana Monteiro Dias, Rita Valerio Alves, Mario Gois, Helena Viana and Fernando Nolasco
Article Type: Original Article | First Published: September 25, 2019
Diabetic nephropathy (DN) has been historically the major cause of kidney disease in diabetic patients. However, recent studies have found a high proportion of diabetic patients with biopsy proven Non-diabetic renal disease (NDRD) or NDRD superimposed on DN. These findings have resurfaced the interest in establishing which of these patients may benefit most from a kidney biopsy. Our study aims to enlighten the prevalence and etiology of biopsy proven NDRD and to explore clinical and morphologic differences encountered in the diabetic patient with NDRD. Nearly half diabetic patients proposed to...
High Anti-Acid Omeprazole Lightweight Capsule for Gastro-Enteric System Acid-Related Disorders Treatment
Longjian Geng, Lidong Han, Lulu Huang, Ziheng Wu, Zhenghong Wu and Xiaole Qi
Article Type: Research Article | First Published: September 26, 2019
Utilization of diverse anti-acid materials is necessary for the preparation of compound omeprazole capsules. However, to gain the satisfied anti-acid effect, use of large amount of anti-acids is always difficult to swallow. This study aimed to develop a lightweight compound omeprazole capsule which could achieve immediately drug releasing with high anti-acid ability in stomach. In this study, we successfully prepared OMZ-CD, which were characterized and compared with micronized OMZ. An improved OMZ immediate-release capsule was prepared, and in vitro release behavior and pharmacokinetics studi...
Preventing Unwanted Pregnancies in Schizophrenia: The Importance of Patient Education
Smita Agarkar MD and Teresitta Velez BA
Article Type: Short Note | First Published: October 03, 2019
The importance of contraception education and family planning is often underestimated by physicians providing care to people with schizophrenia. When compared to the general population, women with schizophrenia tend to have a higher rate of lifetime sexual partners and low utilization of contraception. While women with schizophrenia have a comparable number of pregnancies to the general population, these pregnancies are significantly more likely to be unplanned and more importantly, unwanted. In a keystone study done by Miller and Finnerty, 44.3% of pregnancies among surveyed women with schizo...
The Experiences of Jordanian Employed Women in Health Sector after Returning from Maternity Leave a Qualitative Study
Ola Naiem Alfuqaha and Ruqayya Zeilani
Article Type: Research Article | First Published: September 26, 2019
Women have played a very important part in the labor force and the term “feminization” has become very common in workplace. In Jordan the latest figures of the Public Institution for Social Security for the year 2012 indicate that the proportion of women who were involved in the organization has been nearly 25% of all the organization participants, many factors influence the levels of women’s economic activity and which include both the legal frameworks and the socio-cultural perceptions (De - partment of Statistics, 2013). The descriptive phenomenology as a qualitative research design w...