Heart Transplant Patients with Severe Cardiac Allograft Vasculopathy Have More Silent Ischemia and Non-Sustained Ventricular Tachycardia
Katrine Berg, Kamillla Pernille Bjerre, Tor Skibsted Clemmensen, Brian Bridal Logstrup, Henning Molgaard, Steen Hvitfeldt Poulsen and Hans Eiskjær
Article Type: Original Articl e | First Published: September 23, 2019
The incidence of sudden cardiac death (SCD) following heart transplantation (HTx) accounts for approximately 20% of post HTx deaths. Ischemia, bradyand tachy-arrhythmias caused by rejection and cardiac allograft vasculopathy (CAV) seem related to SCD. Hence, we aimed to investigate the relation between CAV, arrhythmias and silent ischemia in long-term HTx patients. 49 HTx patients were included. Patients were CAV-classified in accordance with guidelines from International Society of Heart and Lung Transplantation. Patients were divided into predefined CAV groups (CAV 0, CAV 1, CAV 2 + 3). Inci...
Low or Adequate Carbohydrate Diet and Aerobic Exercise Decrease Cardiometabolic Risk in Overweight Women: A Randomized Controlled Clinical Trial
Raquel Simoes Mendes-Netto, Ana Carolina Santos Barbosa Machado, Barbara Lucia Fonseca Chagas, Marina de Macedo Rodrigues Leite, Alan Bruno Silva Vasconcelos, Danielle Góes da Silva and Marzo Edir da Silva Grigoletto
Article Type: Research Article | First Published: October 04, 2019
To evaluate the efficacy of a low carbohydrate diet on body composition and cardiometabolic markers in overweight women undergoing endurance physical training. A randomized, controlled clinical trial included 24 overweight women, 8 of whom consumed low-calorie diets containing an adequate carbohydrate content, while 16 consumed a low carbohydrate diet. The women regularly performed semi-supervised physical exercise (walking/running) for 12 weeks. Body composition (weight, abdominal and hip circumferences) and cardiometabolic parameters were analyzed. Data were analyzed using a two-way analysis...
Acute Liver Injury: Due to a Rare Case Accompanied by Cardiac and Pulmonary Complications
Fatih Zengin, Vafa Suleymanova, Mehmet Rasih Sonsoz and Mustafa Erelel
Article Type: Case Report | First Published: September 30, 2019
One of the most important causes of acute hepatitis is vascular pathologies of the liver. There are several well-recognized forms of vascular injury to the liver, including Budd-Chiari syndrome, ischemic hepatitis, hepatic infarction and passive congestion due to hemodynamic instability. We present a case of acute liver injury accompanied by hemodynamic and respiratory pathologies. A 53-year-old lady was admitted to the emergency department with complaints of abdominal pain, nausea, vomiting for a week. Gastrointestinal examination was normal. Laboratory tests revealed mild thrombocytopenia, p...
Effectiveness and Safety of Tunneled Pleural Catheter Placement in Patients with Malignant Pleural Effusions
Francisco Leon-Roman, Beatriz Pintado-Cort, Diana Chiluiza-Reyes, Edwin Mercedes- Noboa, Carmen Rodriguez-Calle, Diurbis Velasco-Alvarez, Andrea Perez-Figuera, Esther Barbero-Herranz, Paola Arrieta-Narvaez, Carlos Almonacid-Sanchez, Andres Quezada-Loaiza, Beatriz Prieto-Gonzalez and Deisy Barrios-Barreto
Article Type: Review article | First Published: September 26, 2019
Malignant pleural effusion (PE) is a frequent complication that worsens the quality of life and prognosis of patients with end-stage oncologic disease. Preceded only by parapneumonic PE, malignancy is one of the most common causes of pleural exudates and lung cancer accounts for as much as 37% of these cases. We used the modified scale of the Medical Research Council (mMRC) to assess for degree of dyspnea, the scale of the Eastern Cooperative Oncology Group (ECOG) to measure the functional capacity of the patients and the LENT score (prognostic score for malignant PE) to evaluate the mortality...
Intervention for Non-verbal and Minimally-Verbal Individuals with Autism: A Systematic Review
Lynn Kern Koegel, PhD, Katherine M Bryan, BA, Pumpki Su, MA, Mohini Vaidya and Stephen Camarata, PhD
Article Type: Review Article | First Published: September 27, 2019
Most children diagnosed with ASD will present with late onset verbal communication, and at least one third of these children will remain minimally or completely nonverbal throughout their lifespan, speaking few or no words. Challenges with verbal language can negatively affect many areas, including socialization, academics, independent living and employment. The objective of this paper was to systematically review interventions for the treatment of nonverbal and minimally verbal individuals with ASD. This review exclusively selected studies that targeted verbal communication in minimally and n...
Mathematical Hegselmann-Krause (HK) Model Predicts Chemotherapeutic Resistance to Cisplatin in Human Cervical Cancer Cell Lines
John Zihou Chen, Rong Wu, Henry Simpkins, Zhendong Sun and Jianli Chen
Article Type: Original Research Article | First Published: September 25, 2019
Solid tumors usually have a complex cellular components and intercellular interactions in a complex tumor microenvironment. We used a mathematical HK model to predict the change of drug resistance to cisplatin in a mixed sensitive and resistant human cervical cancer cell population and then employed a cytosensitivity assay to evaluate if biological findings could confirm this change predicted by HK model. We used the HK model to predict the resistance to cisplatin in the mixed cell population. To confirm this prediction, we mixed the sensitive and resistant cancer cells and studied their resis...
A Mathematical Method to Easily and Accurately Measure the Tumor Volume of Prostate Cancer on Pathological Slides
John Zihou Chen, Monika Wrzolek, Lynne Opitz and Jianli Chen
Article Type: Original Research Article | First Published: September 21, 2019
For decades, it has been a big challenge to directly and accurately measure an irregularly shaped area for a tumor volume evaluation of prostate cancer. All current methods are not ideal for different reasons. An objective, practical, accurate, and reliable method for measuring of prostate cancer volume is needed, in particular in modern precision medicine setting, pursuing accuracy and quality of health care. In this study, we applied a mathematical method - the Gauss area calculation formula to the evaluation of irregular shape of prostate cancer areas on H&E slides. To simplify the calculat...
Neuromodulation for Drug-Refractory Epilepsy and Chronic Heart Failure: Targets, Delivery, Composition and Titration
Inder S Anand, MD, FRCP, DPhil (Oxon), Marvin A Konstam, MD, Jeffrey L Ardel, PhD3, Imad Libbus, PhD, Lorenzo A DiCarlo, MD and Douglas L Mann, MD
Article Type: Original Articl e | First Published: September 23, 2019
Vagus nerve stimulation (VNS) is used currently in the management of drug-refractory epilepsy (DRE), and is in development for treating chronic heart failure (HF). HF is accompanied by autonomic nervous system (ANS) dysfunction, consisting of sustained sympathetic hyper-activation and withdrawal of parasympathetic tone, and associated with progressive worsening of cardiovascular (CV) function and increased morbidity and m ortality. We sought to compare how VNS is utilized for DRE and may potentially be employed for HF. Neuromodulation for the treatment of epilepsy and HF is not a one-size-fits...
Diabetes in Latin America: Prevalence, Complications, and Socio- Economic Impact
L Sinisterra-Loaiza, A Cardelle-Cobas, AG Abraham, MN Calderon, MA Espinoza, LG Gonzalez- Olivares, M Gotteland, A Pazos-Sierra, S San Martin, A Cepeda, JJ Gagliardino and IBEROBDIA Project Group
Article Type: Research Article | First Published: September 28, 2019
To review and update epidemiological data on type 2 diabetes (T2D) in Spain and four Latin American countries: Colombia, Mexico, Chile, and Argentina. Literature was reviewed by a search of PubMed, publications of the Ministry of Health, World Health Organization, International Diabetes Federation, and other public health agencies of each respective country. Of the five countries above, Mexico (13.6%) had the highest prevalence of diabetes, followed by Spain (10.4%). Within these countries, significant differences between urban and rural areas were observed (7.8% and 1.4%, respectively). Diabe...
The Role of Human Papillomavirus in Cervical Cancer
Beata Smolarz, Dariusz Samulak, Marianna Makowska, Hanna Romanowicz, Zbigniew Kojs, Luiza Wojcik and Magdalena M Michalska
Article Type: Review Article | First Published: September 28, 2019
Long-term infection with human papillomavirus (HPV) is the cause of cervical cancer and its precursor - cervical intraepithelial neoplasia (CIN). The presence of HPV infection can be presumed in more than 99% of cases of cervical cancer worldwide. The introduction of DNA testing for the presence of HPV has increased the effectiveness of screening programs for the detection of this cancer. This article contains the latest reports on the structure, function and role of HPV in the development of cervical cancer. It was also underlined the importance of performing molecular tests for the presence ...