ClinMed International Library

The ClinMed International Library is a repository and an open access publisher for medical research that covers a wide range of areas in Clinical Medicine. ClinMed serves as a global platform for medical practitioners and research scholars to foster their learning and professional acumen through an extensive portfolio of research articles and publications that can be accessed without any restrictions.

Dedicated to clinical medical research, we now publish over 70 quality peer-reviewed journals making all the articles freely accessible. The manuscripts submitted to ClinMed will be processed through standard parameters and international peer review systems. This has enabled us to establish new milestones in the global research arena in terms of cogency and integrity, and to disseminate highly credible and accredited research content for researchers, scholars, and practitioners across the globe.

We ensure that all researchers and authors publishing their papers with us retain copyrights, licensed under Creative Commons Attribution License that permits the unrestricted use and re-use of the content with proper citation.

ClinMed International Library

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Articles Published

All articles are fully peer reviewed, free to access and can be downloaded from our ClinMed archive.

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 Open Access DOI:10.23937/2469-5750/1510075

A New Way to Inhibit IL-17 in Psoriasis: Real-Life Use of Brodalumab Goes Beyond Clinical Trials Expectations

Mario Valenti, Paola Facheris, Giulia Pavia, Alessandra Narcisi, Riccardo Borroni and Antonio Costanzo

Article Type: CASE SERIES | First Published: December 30, 2019

Psoriasis is a common inflammatory skin disease that is estimated to affect about 2-4% of the population, with rates varying across ethnic groups and geographical regions. Biotechnological (more commonly called biologic drugs) drugs have shown great results in treating severe forms of psoriasis. Biologic agents that specifically block the IL-17 pathway have shown promising results with regard to efficacy and safety. Specific IL-17 inhibitors are represented by Secukinumab and Ixekizumab, fully human and humanized (respectively) monoclonal antibodies against IL- 17A, while Brodalumab is a fully...

 Open Access DOI:10.23937/2378-3397/1410106

Laparoscopic Peritoneal Lavage versus Sigmoidectomy for Management of Perforated Diverticulitis: Meta-Analysis of Randomized Controlled Trials

Arslan Pannu, Ghulam Murtaza Dar, Shahzad Ahmed, Shahab Hajibandeh, Shahin Hajibaneh, Eloise Lawrence, Salman Jabber, Khurram Khan, Rishabha Sharma and Ahmad Mirza

Article Type: Review Article | First Published: January 04, 2020

Controversy exists regarding the role of laparoscopic peritoneal lavage in patients with perforated diverticulitis. Our objective was to conduct the first meta-analysis of Randomized Controlled Trials (RCTs) to compare the outcomes of patient undergoing laparoscopic peritoneal lavage with sigmoidectomy in patients with perforated diverticulitis. In accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement standards, we conducted a systematic search of electronic information sources, including MEDLINE; EMBASE; CINAHL; CENTRAL; The World Health Organiz...

 Open Access DOI:10.23937/2378-3516/1410127

Dank or Disease? A Case of Vape Associated Pneumonitis in a 19-Year-Old Male

Jalla T Mustafa, DO, Amanda V Wright, DO, Jesse L Wolfe, OMSIII and Anand Popuri, DO

Article Type: Case Report | First Published: January 04, 2020

A 19 y/o male with no significant past medical history presented to the hospital in acute respiratory distress with SOB, dyspnea, chills, cough productive of green sputum, nausea and vomiting refractory to low dose steroids and broad spectrum antibiotics. Patient had no other significant history except for 2 years of vaping, including more recently the use of a THC-infused cartridge preceding the onset of his symptoms. Prior imaging was negative but now chest CT showed extensive bilateral ground glass, interstitial, alveolar infiltrates, confluent in the lower lung zones with resultant air bro...

 Open Access DOI:10.23937/2378-3516/1410126

Paediatric Empyema Thoracis: Roles and Outcomes of Surgical Intervention in Advanced Disease

YL Ho, M Fauzi, Sothee K, A Salleh, AY Khamis and Basheer A Kareem

Article Type: Research Article | First Published: January 03, 2020

Empyema thoracis has become increasingly common in paediatric population. Antibiotics and thoracostomy have been the cornerstones in managing stage 1 empyema, where as management of stage 2-3 empyema remains controversial. Surgical intervention is perceived to be associated with high morbidity and protracted recovery. This paper reviews the roles and outcomes of surgical decortication, and to provide data for comparison with other treatment modalities. Thirty children (median age 5.2 years, range 2 months to 12 years) with stage 2-3 empyema who underwent surgical decortications in our unit fro...

 Open Access DOI:10.23937/2643-4571/1710014

Case Series Synopsis: Gaucher Disease Type 1 Patients Treated with Eliglustat over 6 Years

Cristina Fraga, Sonia Medeiros, Sara Serpa and David Silva

Article Type: Case Series | First Published: January 08, 2020

Gaucher disease (GD) type 1 is a lysosomal storage disorder associated with bone disease, hepatosplenomegaly, anemia and thrombocytopenia. Here we present a case series from 5 (3 females and 2 males) Portuguese individuals from a single institution with GD type 1 who were treated with substrate-reduction therapy (eliglustat, 84 mg once or twice daily) for 6-years. Four cases were switched from IV imiglucerase (28 U/kg q2 week [n = 1]) or 45 U/kg q2 week [n = 3]) and one was enzyme-replacement therapy naive prior to eliglustat dosing. Two patients had 1304A > C (homozygous)/ N435T mutations and...

 Open Access DOI:10.23937/2572-4215.1510019

Prognostic Factors for Disability and Pain Outcomes in Patients with Axial Low Back Pain Undergoing a Multidisciplinary Spine Treatment Program

Nicholas K Donohue, Emily J Graf, Alexis M Visotcky, Sergey S Tarima and Andrew C Hsu

Article Type: Research Article | First Published: January 11, 2020

Several studies in the past have examined factors impacting improvement in low back pain in the primary care context. However, there is limited evidence regarding prognostic factors for pain and disability scores in patients with axial low back pain entering a multidisciplinary spine program. The goal of this study was to assess which baseline demographic, disability, and pain-related characteristics may be prognostic for improvement in pain and disability scores entering a multidisciplinary spine program. This was a retrospective review of patients with axial low back pain who participated in...

 Open Access DOI:10.23937/2469-5734/1510105

Amnion-Chorion Strips in the Treatment of Peri-Implantitis, Report of a Case

Mohamed A Maksoud, DMD

Article Type: Case Report | First Published: January 04, 2020

Dental implant disease described as Peri-implantitis is bacterial inflammation of the implant surrounded soft and hard tissue that can lead to bone loss and eventual failure of the implant fixture. Several protocols have been introduced to treat implantitis including the use of systemic and local antibiotics in addition to bone grafting in advanced cases. Although the treatment outcome is effective in the early to moderate cases its unpredictable in cases with severe bone loss. Human placental tissue has been introduced in medicine for the treatment of burns and ophthalmic disease around the t...

 Open Access DOI:10.23937/2378-3001/1410095

Towards a Biological Definition of Alzheimer Disease

Kurt A Jellinger, MD

Article Type: Commentary | First Published: January 08, 2020

Alzheimer disease (AD), the most common form of dementia, is a heterogenous syndrome with various pathobiologically defined subtypes. The clinical diagnosis of probable AD is enabled by the recent ATN biomarker system, but the definite diagnosis is only possible at post-mortem according to the updated NIA-AA criteria. The recent developments in the clinical and neuropathological diagnosis of AD including its specific subtypes improving the evaluation of AD and its impact on public health are briefly discussed. Alzheimer disease (AD), the most common form of dementia that currently affects arou...

 Open Access DOI:10.23937/2378-3001/1410094

Polymyositis in Adamantiades-Behcet's Disease

Carlos Arteaga Rodriguez, MD, MSc, Otto J Hernandez Fustes, MD, MSc, Renato Puppi Munhoz, MD, PhD and Olga Judith Hernandez Fustes, MD, MSc

Article Type: Case Report | First Published: January 04, 2020

Although Adamantiades-Behçet’s disease (ABD) has a worldwide distribution, it is considered rare in the Americas, with a prevalence of 0.12-0.33:100.000 in the United States. The characteristic triad of recurrent oral aphthous lesions, genital ulcers and iridociclitis occurring more often in young adults during their third or fourth decade of life was initially described by Hippocrates but gained it's classic eponym to acknowledge the Greek ophthalmologist from Asia Minor (nowadays part of Asian Turkey) Benediktos Adamantiades and Turkish dermatologist Hulusi Behçet, who in first identifi...

 Open Access DOI:10.23937/2643-4539/1710014

Predictors of Health-Related Quality of Life and Communicative Participation in Individuals with Dysarthria from Parkinson’s Disease

Kristie A Spencer, Clare Friedlander and Katherine A Brown

Article Type: Researc h Article | First Published: January 03, 2020

The motor and non-motor deficits of Parkinson’s disease (PD) can cause daily challenges and have been associated with reduced health-related quality of life (HrQoL). A number of variables have been consistently, though not unequivocally, identified as important in influencing overall HrQoL in individuals with PD, such as demographic factors, cognitive decline, and level of motor impairment. However, the presence and severity of dysarthria is often overlooked, despite the potentially adverse influence on HrQoL. The primary purpose of this study was to understand the predictors of HrQoL, as we...

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