Sex Differences in the Antidepressant Effects of Ketamine in Animal Models of Depression
Frank Adu-Nti, George Ghartey-Kwansah and Benjamin Aboagye
Article Type: Review Article | First Published: July 19, 2019
Major depressive disorder (MDD) is the most common psychiatric disease and it affects millions of people across the world. Patients suffering from MDD consistently complain about cognitive disturbances, significantly worsening the burden of this illness. The second most frequent mental illness in Europe is mood disorders and they are dominated by MDD, aﬀecting 7% of the population. The recent discovery that the N-methyl-D-aspartate receptor (NMDAR) antagonist; ketamine; a revolutionary novel antidepressant, rapidly relieves depressive symptoms and suicidal imaginations, particularly amongst ...
Comparison of the Sequential Organ Failure Assessment (SOFA) and Quick SOFA Scores in Predicting in-Hospital Mortality among Adult Critical Care Patients with Suspected Infection
Mohammed A Said, MBChB, MPH, Wangari-Waweru Siika, MBChB, Vitalis Mung'ayi, MBChB and Reena Shah, MBChB, MRCP, MSc
Article Type: Original Article | First Published: July 13, 2019
Sepsis is global health priority and the leading cause of death in critical care. The SEPSIS 3 criteria introduced in 2016 is the latest tool in diagnosing sepsis. It uses SOFA and qSOFA scores in place of the SIRS criteria for better ability to predict mortality in patients with suspected infections. The performance of these scores in critical care units outside high-income countries remains largely unknown....
Left Main Coronary Artery Dissection during Breastfeeding Treated with CABG Complicated by Severe Ventricular Disfunction and Left Ventricular Thrombosis
Nicolo Sisti, MD, Giulia Elena Mandoli, MD, Antonio Pagliaro, MD, Giuseppe Guerrieri, MD, Carlotta Sciaccaluga, MD, Matteo Cameli, MD, PhD, Sergio Mondillo, MD and Serafina Valente, MD
Article Type: Case Report | First Published: July 18, 2019
Spontaneous coronary artery dissection (SCAD) should always be suspected in presence of chest pain during post-partum, since it is one of the possible causes. Strategies for the management of such disease and its complication are not still clearly encoded. A 40-years-old woman was referred with chest pain, started while breastfeeding, associated with an EKG pattern suggesting ischemia. After hospital admission, coronary angiography was performed showing a Type 1 left main coronary dissection. Given persistent symptoms, hemodynamic instability and persistent EKG alterations the patient underwen...
Is There Any Relationship between ABO Blood Groups and Coronary Ectasia?
Article Type: Research Article | First Published: July 17, 2019
Coronary artery ectasia (CAE) is known as dilatations of coronary vessels which are 1.5 times greater than the adjacent healty segment and it is known to variant of atherosclerosis. Previous reports have shown that the ABO blood groups are associated with atherosclerosis. In this study, it was investigated whether coronary artery ectasia is related to genetically transmitted ABO blood groups. This retrospective study involved 620 subjects who underwent coronary angiography in our center from 2015 to 2018. The control group of the study consisted of 310 patients whose coronary arteries were ang...
Mindfulness Based Cognitive Therapy for Substance Abuse and Depression: A Case Study
Uepndra Singh and Sweta
Article Type: CASE STUDY | First Published: July 20, 2019
Mindfulness is increasingly conceptualized in terms of its regulatory function with research suggesting that mindfulness may have a constructive effect on psychological well-being. A systematic review of the few existing MBCT randomized controlled trials concluded that MBCT has an additive benefit to usual care in preventing depressive relapse for individuals with three or more previous depressive episodes. Mindfulness is an effective tool which help people with addiction because it is a simple skill that anyone can practice multiple times throughout a day regardless of the life challenges tha...
Coronary Artery Bypass Graft Surgery in a Young Female with Systemic Lupus Erythematosus and its Operative Challenges: A Case Report
S Gurpreet, MRCS, SJ Vendargon, MS and SH Syed Rasul, FRCS
Article Type: Case Report | First Published: July 25, 2019
We understand that an autoimmune disorder such as Systemic Lupus Erythematosus increases the likelihood of developing coronary heart disease. However its implications on patients undergoing cardiac surgery are not well understood. Here we present a female patient with SLE who developed coronary artery disease at a young age and underwent coronary artery bypass graft surgery. As SLE is associated with vasculitis, we wanted to understand regarding the choice of conduit as well as its long term patency and also whether percutaneous angioplasty has a role to play in patients with SLE....
A Great Mimicker of Acute Cholecystitis in Young Population: A Case Report and Literature Review
Mehmet Karagulle, Fatma Zeynep Arslan, Esra Bilgi, Suleyman Oncu1, Samet Simsek and Mehmet Oncu
Article Type: IMAGE ARTICLE | First Published: August 02, 2019
Gallbladder agenesis is a rare biliary anomaly which can be important for patients complaining of chronic abdominal pain. Gallbladder agenesis can mimic cholecystitis by causing recurrent upper abdominal pain and tenderness. In a significant number of patients with gallbladder agenesis, unnecessary surgical procedures are performed because of the misdiagnosis. The morbidity of the disease can reduce, since the correct diagnosis of gallbladder agenesis decrease unnecessary surgical procedures. The diagnosis can be established with performing ultrasound and Magnetic resonance cholangiopancreatog...
Rhabdomyosarcoma of the Tongue
Maha OUDRHIRI, Amina KILI, Laila HESSISSEN, Maria EL KABABRI, Mohamed EL KHORASSANI and Mohamed KHATTAB
Article Type: IMAGE ARTICLE | First Published: June 29, 2019
The clinical examination finds an exophytic mass at the expense of the tongue, measuring 3 by 2 cm in diameter. The mass is of muscular consistency, not painful, deeply indurated extending on the left edge of the tongue with infra-centimeter and sub-mandibular cervical lymphadenopathy. The examination also finds 6 coffee-and-milk spots. A CT scan was immediately performed, showing a lingual process weakly heterogeneously after injection of contrast medium, measuring approximately 35*45 mm locally advanced. The mass was biopsied, which led to the diagnosis of embryonic rhabdomyosarcoma poorly d...
Risk of Osteonecrosis of the Jaw in Patients with Postmenopausal Osteoporosis: A Systematic Literature Review
Gloria Candelas, Virginia Villaverde, Petra Diaz, Mercedes Guerra and Antonio Naranjo
Article Type: SYSTEMATIC REVIEW | First Published: July 25, 2019
The studies retrieved by the above strategies were included if they met the following pre-established criteria. The patients studied had to be diagnosed of osteoporosis (all ages, both sexes), and they had to be taking Dmab. We measured the likelihood of having osteonecrosis of the jaw. We included in the search for systematic reviews randomised clinical trials (RCT) and cohort studies. We excluded articles on cancer or other disease other than osteoporosis, animal and basic science studies....
A Review of the Most Common Dermatologic Conditions and their Debilitating Psychosocial Impacts
Madeeha Mian, BA, Annika S Silfvast-Kaiser, MD, So Yeon Paek, MD, Dario Kivelevitch, MD and Alan Menter, MD
Article Type: Review Article | First Published: July 22, 2019
The majority of skin conditions are not life-threatening; however, many can be severe and disfiguring enough to devastate a patient's quality of life. Skin diseases can significantly impact not only a patient's physical appearance, but also their social and emotional well-being. Even the smallest skin lesions have been shown to disrupt a person's level of overall wellness. Here, we aim to address the potential psychological and emotional impact of the most common and debilitating dermatologic conditions. We describe how skin disorders affect individuals and subsequently, how they are perceived...