Marked Increases in Alpha Power Over the Left Prefrontal Region During Days Following Shift Work: A Case Report
Nirosha J. Murugan, Nicolas Rouleau, Lukasz M. Karbowski, Andrew P. Lapointe and Michael A. Persinger
Article Type: Case Report | First Published: September 10, 2015
Quantitative electroencephalographic (QEEG) measurements were completed for a 35 year old of paramedic following two to five days of shift change and rest periods. The most conspicuous and reliable change was a marked increase (factor of 5) in power within the alpha band over the left prefrontal region and, to a lesser degree, increased power within the low-beta band over the right parietal region during the test periods after no work days. These results indicate that regions of cerebral cortices associated with self-monitoring and spatial vigilance are most affected by a schedule that involve...
Association of SORL1 Polymorphisms with the Risk of Amnestic Mild Cognitive Impairment in the Han Chinese Population
Lili Zhang, Xiaowei Liu, Bailing Wang, Qing Xu, Jianzhong Zhu, Feng Zhang and Chunhui Jin
Article Type: Communication | First Published: September 14, 2015
Mild cognitive impairment (MCI) is defined as the symptomatic predementia stage, characterized by cognitive impairment that is not severe enough to influence the usual activities of daily living. MCI is suggested to be a transitional state between healthy aging and clinically probable Alzheimer's disease (AD). Previous studies have identified that single nucleotide polymorphisms (SNPs) in the sortilin-related receptor, L (DLR class) A repeats containing (SORL1) gene are associated with amnestic MCI (aMCI). To further investigate the relationships between SORL1 genetic variants and aMCI, we con...
Bayesian Survival Analysis of Genetic Variants in PTPRN2 Gene for Age at Onset of Cancer
Ke-Sheng Wang, Yue Pan, Weize Wang and Chun Xu
Article Type: Research Article | First Published: September 9, 2015
The protein tyrosine phosphatase, receptor type, N polypeptide 2 (PTPRN2) gene may play a role in cancer; however, no study has focused on the associations of genetic variants within the PTPRN2 gene with age at onset (AAO) of cancer. Methods: This study examined 220 single nucleotide polymorphisms (SNPs) within the PTPRN2 gene in the Marshfield sample with 716 cancer cases (any diagnosed cancer, excluding minor skin cancer) and 2,848 non-cancer controls. Multiple logistic regression model and linear regression model in PLINK software were used to examine the association of each SNP with the ri...
A Review of Graphical Approaches to Common Statistical Analyses. The Omnipresence of Latent Variables in Statistics
Emil N. Coman, L. Suzanne Suggs, Maria Coman and Eugen Iordache and Judith Fifield
Article Type: Review Article | First Published: September 4, 2015
We provide a comprehensive review of simple and advanced statistical analyses using an intuitive visual approach explicitly modeling Latent Variables (LV), likely to better illuminate what is assumed in each analytical method and what is actually estimated, by translating the causal relationships embedded in the graphical models in equation form. We recommend the graphical display rooted in the century old path analysis, that details all parameters of each statistical model, and suggest labeling that clarifies what is given vs. what is estimated....
Drug Treatment Comparison for Total Knee Replacement Surgery
Kevin Soderholm and Rhonda Magel
Article Type: Research Article | First Published: September 02, 2015
Data from over 2000 patients receiving knee replacement surgery was gathered from a hospital system in the Midwestern United States. The age group that each patient belonged to was noted, under age 65 or 65 years of age and older, as well as their gender. A variety of drugs in each of three drug categories was studied as to their association with total hospital cost, length of stay, prevalence of early readmissions and prevalence of blood transfusions. The drug categories included spinal blocks, anticoagulants, and antifibrinolytics....
Coexisting Normal- Tension Glaucoma and Deficiencies of Folic Acid and Vitamin B6 (Pyridoxal)
Article Type: Case Report | First Published: September 06, 2015
A 43-year-old man presented with bilateral visual field defect. Large disc cupping, retinal nerve fiber layer defect, and normal intraocular pressure were found in both eyes. Although the patient was prescribed an anti-glaucoma eye drop, the visual field defect deteriorated after two months of treatment. The patient was diagnosed with sensory, taste, and hearing impairments, as well as depression, caused by folic acid and vitamin B6 (pyridoxal) deficiencies at an internal medicine department. The Visual field and ocular blood flow improved after two months of treatment with folic acid and pyri...
Topic: Acute Kidney Injury in Children: 3-Year Data Review from Ghana
Sampson Antwi, Anima Sarfo, Abigail Amoah, Anna Serwaa Appia and Esther Obeng
Article Type: Research Article | First Published: September 14, 2015
Acute kidney injury (AKI) is a relatively common condition encountered in everyday paediatric practice. It remains a significant contributor to preventable deaths especially in resource constraint regions of the world largely due to lack of dialysis services.
This 3-year data analysis (2010-2012) was undertaken to determine the aetiology and treatment/mortality outcomes of children with AKI presenting to a Teaching Hospital in Ghana. AKI was defined in this analysis by the RIFLE and KDIGO criteria....
Hormonal Therapy for GI Angiodysplasia: Out of Hope After Failure of the Scope?
Ujjwal Kumar, Kevin Cowley and Frederick Weber
Article Type: Case Report | First Published: September 14, 2015
Angiodysplasia of the gastrointestinal (GI) tract can present both diagnostic and therapeutic challenges. Despite the recent advances in endoscopy, many patients continue to suffer from recurrent bleeding. We report a remarkable case of a multi-year history of transfusion-requiring obscure overt recurrent GI bleeding, refractory to multiple endoscopic therapies as well as both octreotide and thalidomide. Upon initiation of hormonal therapy, the patient's bleeding completely resolved, with complete cessation of transfusion and procedure requirements for 18 months....
Effect of Biologics on the Outcomes of Inflammatory Bowel Disease: A Retrospective Study on a Large Pediatric Cohort
Hoda M. Malatyr, Bincy Abraham, Mina S. Emil, George D. Ferry and Elizabeth A. Garnett
Article Type: Research Article | First Published: September 11, 2015
The incidence of inflammatory bowel disease (IBD) in children has increased over the past 20 years and treatment with biologics is increasingly used.
Objective: We assessed the associations of biologics to IBD outcomes in children.
Methods: A retrospective investigation was conducted on a cohort of children with IBD between 1988/2008 who were enrolled in the Pediatric IBD registry. The diagnosis of IBD was based on clinical, radiological, endoscopic, and/or histological examinations. Clinical outcome measures were grouped into surgical, extra intestinal manifestations (EIMs), and frequen...