ClinMed International Library

The ClinMed International Library is a repository and an open access publisher for medical research that covers a wide range of areas in Clinical Medicine. ClinMed serves as a global platform for medical practitioners and research scholars to foster their learning and professional acumen through an extensive portfolio of research articles and publications that can be accessed without any restrictions.

Dedicated to clinical medical research, we now publish over 70 quality peer-reviewed journals making all the articles freely accessible. The manuscripts submitted to ClinMed will be processed through standard parameters and international peer review systems. This has enabled us to establish new milestones in the global research arena in terms of cogency and integrity, and to disseminate highly credible and accredited research content for researchers, scholars, and practitioners across the globe.

We ensure that all researchers and authors publishing their papers with us retain copyrights, licensed under Creative Commons Attribution License that permits the unrestricted use and re-use of the content with proper citation.

ClinMed International Library

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Articles Published

All articles are fully peer reviewed, free to access and can be downloaded from our ClinMed archive.

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 Open Access DOI:10.23937/2469-570X/1410018

Mammary Epithelial Cell Lineage Analysis via the Lyon's Hypothesis

Andrea L. George and Gilbert H. Smith

Article Type: Case Report | First Published: January 03, 2016

Implants of mammary glands from a single mammary fat pad in a H253 transgenic female mouse heterozygous for a lacZ-labeled X chromosome were analyzed at various time points following transplantation into the epithelium-cleared mammary fat pads of immune-compromised mice. The results show that the lacZ-marked X chromosome, demonstrated by nuclear-associated X-gal staining, was confined to a single epithelial clone that gave rise to the cap cells of all growing terminal end buds (TEB) in the expanding mammary outgrowths and also the basal cells of the elongated ducts....

 Open Access DOI:10.23937/2469-570X/1410017

Ex-Vivo Expansion of Cardiac Stem Cell Therapy Products for Clinical Use: The Importance of Moving towards the Optimization of Process Development

Silvana Bardelli and Marco Moccetti

Article Type: Short Review | First Published: January 03, 2016

Preliminary studies based on stem cells were initially applied to the clinical setting of acute myocardial infarction (AMI) with the purpose of delivering a cardioprotective effect. The field has then rapidly expanded to embrace chronic heart failure as a cardiorestorative therapy. For the easiness of collection as hematologic tissue, Bone Marrow (BM)-derived stem cells were utilized as the primary source of these applied therapies. Specifically, unselected Bone-Marrow Mononuclear Cells (BMMNCs) fuelled the first generation of clinical trials focused on cardiac regeneration....

 Open Access DOI:10.23937/2469-570X/1410016

Regulation of Normal Somatic Cell and Cancer Cell Reprogramming by p53

Jie Yuan and Qin Yang

Article Type: Review Article | First Published: December 24, 2015

Reprogramming healthy somatic cells into disease-relevant cell types through cellular reprogramming has been intensively investigated. The discovery of reprogramming methods holds the promise of generating desired cells for disease modeling, drug screening studies and treatment of numerous diseases. Recently studies also focus on different disease cell reprogramming, including cancer cell reprogramming. Reprogramming and tumorigenesis share many similarities and the tumor suppressor p53 suppresses both processes....

 Open Access DOI:10.23937/2469-570X/1410015

Neural Stem Cells and their Niches in Neuroregeneration

Jong-Hang Chen, Mei-Shu Chen, Su-Liang Chen and Ing-Ming Chiu

Article Type: Review Article | First Published: December 21, 2015

Stem cell-based therapies in alleviating symptoms or reversing the progression of neurodegenerative diseases and nerve injuries have been investigated extensively. In this review, we first summarize our current understanding of the ontogeny of neural stem cells (NSCs) and their mobilization in vivo. We then focus on the cellular reprogramming in generation of iP-NSCs, iNeurons and iNSCs, and applications of NSCs and iNeurons in cell-based therapy, disease modeling and drug discovery. NSCs belong to the adult stem cells, which can self-renew and differentiate into neurons, astrocytes and oligod...

 Open Access DOI:10.23937/2469-5726/1510027

Aspirin-Triggered Resolvin D1 Versus Dexamethasone in the Treatment of Sjogren's Syndrome-Like NOD/ShiLtJ Mice - A Pilot Study

Justin T Easley, Joel W Nelson, Rachel E Mellas, Salah Sommakia, Chunhua Wu, Bryan Trump, and Olga J Baker

Article Type: Research Article | First Published: December 17, 2015

Resolvin D1 (RvD1) and its aspirin-triggered epimeric form (AT-RvD1) are endogenous lipid mediators (derived from docosahexaenoic acid, DHA) that control the duration and magnitude of inflammation in models of complex diseases. Our previous studies demonstrated that RvD1-mediated signaling pathways are expressed and active in salivary glands from rodents and humans. Furthermore, treatment of salivary cells with RvD1 blocked TNF- -mediated inflammatory signals and improved epithelial integrity. The purpose of this pilot study was to determine the feasibility of treatment with AT-RvD1 versus dex...

 Open Access DOI:10.23937/2469-5726/1510026

A Rare Coexistence of Seronegative Enthesopathy and Arthropathy Syndrome with Familial Mediterranean Fever

Hakan Genc, Alper Gumustepe, Fikriye Figen Ayhan and Aynur Karagoz

Article Type: Case Report | First Published: November 18, 2015

The juvenile-onset spondyloarthropathies begin at age of 16 years or younger and are associated with the HLA-B27 allele. They are classified as the enthesitis-related arthritis (ERA) subgroup of juvenile idiopathic arthritis (JIA) by the international league of associations for rheumatology (ILAR) [1]. Although the adult form has inflammatory low back pain as the predominant clinical symptom, the juvenile form has peripheral enthesitis and arthritis as its main clinical features. For this reason, Rosenberg and Petty proposed the concept of the seronegative enthesopathy and arthropathy (SEA) sy...

 Open Access DOI:10.23937/2469-5726/1510025

In the Idiopathic Inflammatory Myopathies, How Significant is Creatine Kinase Levels in Diagnosis and Prognosis? A Case Study and Review of the Literature

Travis C Sizemore

Article Type: Case Report | First Published: November 18, 2015

The clinical significance of creatine kinase [CK] levels in idiopathic inflammatory myopathies [IIM] has varied between studies. CK levels continue to be the most sensitive laboratory marker for muscle disease in IIM but vary depending upon the disease entity. The goal of this article was to further elucidate the clinical significance of CK levels in the setting of IIM, including role of CK in diagnostics and prognostication. A case report was described with a subsequent literature review completed by searching within high quality peer-reviewed articles in the Cochrane Review database as well ...

 Open Access DOI:10.23937/2469-5726/1510024

Hypercoagulation in Patients with Rheumatoid Arthritis Correlates with Activation of Act1/NF-kb Signaling Pathway

Pingheng Zhang, Jian Liu and Bing Tan

Article Type: Research Article | First Published: November 16, 2015

Peripheral blood samples were taken from 30 RA patients and 20 healthy volunteers, as controls. Ex vivo correlates of disease severity, such as C-reactive protein, erythrocyte sedimentation rate, anti-cyclic citrullinated peptide and rheumatoid factor, and immunological activation, such as interleukin (IL)-10, IL-17 and IL-6 were measured biochemically. Factors derived from the coagulation fibrinolytic system were also determined, such as the number of platelets, platelet activating factor, platelet activating factor-acetylhydrolase, D-dimer, thrombin time, prothrombin time, partial thrombopla...

 Open Access DOI:10.23937/2469-5823/1510025

Cross-sectional Survey: Public Attitude toward Mental Illness in China

Anson Chui Yan Tang

Article Type: Review Article | First Published: December 31, 2015

Public attitude toward mental illness is usually negative in many western and Asian countries. Both qualitative and quantitative studies have reported that Chinese societies possess a lower benevolence toward and impose more social restriction on the mentally ill. People with mental illnesses are being labelled as dangerous and aggressive, and their families are being disapproved of and devalued....

 Open Access DOI:10.23937/2469-5823/1510024

Making IPE Work: Idea to Actualization

Kimberly A. Udlis and Stephanie Stewart

Article Type: Commentary | First Published: December 31, 2015

According to the World Health Organization Interprofessional Care (IPC) is linked with improved outcomes in family health infectious disease humanitarian efforts, responses to epidemics and non-communicable disease. Others improvements with IPC are noted in access to care and coordination of services, appropriate use of specialty care, chronic disease outcomes and safety. Safety indicators include complications and error rates, lengths of stay, conflict among care givers, staff turnover and mortality rates which are improved in collaborative care environments....

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