Simultaneous Corneal Allograft and Contralateral Corneal Autograft: A Case Report
Sitaula Sanjeeta and Singh Sanjay K
Article Type: Case Report | First Published: January 21, 2019
Autologous contralateral autograft has been described as a useful procedure in patients who require penetrating keratoplasty on their only functional eye and have a clear cornea on their nonfunctional eye due to the low chances of graft rejection in autografts. Here we describe a case where we were able to salvage vision by corneal autografting in a blind patient. A 65-year-old male had blurred vision in both eyes with visual acuity of perception of light (PL) in right eye (RE) and hand motion (HM) in left eye (LE). On examination, RE had a clear cornea, sluggish pupillary reaction with presen...
Alcohol Biomarkers and their Relevance in Detection of Alcohol Consumption in Clinical Settings
Shayani Ghosh, Raka Jain, Sonali Jhanjee, Ravindra Rao and Ashwani Kumar Mishra
Article Type: Review Article | First Published: January 21, 2019
Alcohol use disorder is a growing public health concern worldwide. Accurate assessment is an important step towards effective management of the patient suffering from alcohol use disorder. Self-report often lacks accuracy and may be misleading in a hesitant patient. The use of biochemical laboratory measures such as alcohol biomarkers, often helps in obtaining independent estimations of alcohol use. The traditional biomarkers (such as Aspartate Aminotransferase, Alanine Aminotransferase or Mean Corpuscular Volume) have lower specificity as number of other comorbid disease conditions can indepe...
Improved Timeliness of Care for the Underserved: A Potential for Patient Navigation
Jason F Ohlstein, Thomas S Edwards, Charles A Riley, Joseph F Buell and Paul L Friedlander
Article Type: Original Article | First Published: Janaury 21, 2019
Retrospective chart review of 100 consecutive patients presenting from each of two tertiary referral centers in inner city New Orleans, Louisiana located in the same zip code serving the local community, with a new diagnosis of squamous cell carcinoma of the head and neck between 2011 and 2014.The data from 187 patients were analyzed for delay at presentation and subsequent provider delay. Statistical analysis was performed to evaluate the effect of race, insurance status, and patient navigation on patient and provider delay using....
Gastrointestinal Stromal Tumor: Diagnosis and Management
Yasemin Altıntas and Mehmet Bayrak
Article Type: Original Article | First Published: January 18, 2019
To investigate the frequency, management, and consequences of gastrointestinal stromal tumors in thirty patients treated and followed up at a single site. All gastrointestinal stromal tumor patients admitted to our institution from 2008 to 2018 were retrospectively reviewed. Demographics, clinical findings, and tumor features, pathological, radiological, and immunohistochemical observations, surgical technique, recurrence, and mortality were documented. Thirty patients were selected for this study, the primary tumor locations were the stomach (46.7%) and small intestine (43.3%)....
Repair versus Replacement: A Questionnaire Examining the Repair Preferences of Turkish Dentists in Dental Restorations
Omer Hatipoglu and Banu Aricioglu
Article Type: Research Article | First Published: January 12, 2019
To investigate the preferences of Turkish dentists in repairing dental materials. 344 Turkish dentists participated the survey. The questionnaire consisted of 3 sections. In the first part demographic features were asked. The case was presented in the second part; How treatment plans change was asked in the cases such as partial loss of restoration, discoloration, loss of hard substance, secondary caries, marginal discoloration, and marginal gap. In the third part, the most frequently used materials in repairing were demanded....
Evaluation of Synergetic Antibacterial Effect of Gaseous Ozone and Ozonated Water against Enterococcus Faecalis in Human Root Canals
Banu Uygun Can, Gizem Ozbay, Hatice Altundal, Parla Meva Durmazpinar, Burak Kitiki, Sertac Peker, Tanju Kadir and Betul Kargul
Article Type: Research Article | First Published: December 28, 2018
Elimination of the microorganisms in root canals is one of the most important stages for a successful endodontic treatment. Several techniques and agents have been tested to find an alternative option to sodium hypochloride for effective root canal disinfection. The aim of this in vitro study was to evaluate the antimicrobial efficacy of gaseous ozone and ozonated water in order to establish their potential as endodontic root canal disinfectant....
Impact of a Dedicated Multidisciplinary Research and Treatment Network on Outcomes of Muscle-Invasive Bladder Cancer Patients
Debbie G Robbrecht, Rob HA Verhoeven, Peter de Vries, Michiel S van der Heijden, Joost L Boormans and Ronald de Wit (on behalf of the Dutch Uro-oncology Study group (DUOS))
Article Type: Original Article | First Published: February 09, 2019
Our retrospective analysis based on 3472 muscle-invasive bladder cancer patients, showed a non-significant trend towards survival benefit when treated in hospitals involved in a national study-group network (DUOS), with significantly superior outcomes concerning neo-adjuvant chemotherapy, surgical margins and lymph node dissection. These factors significantly correlated with an improved survival, favoring treatment at centers that are involved in a multidisciplinary national network with dedicated care for bladder cancer....
Exemestane-Induced Eosinophilic Colitis in a Patient with Grade 3 Ductal Carcinoma In-Situ: A Case Report and Review of the Literature
Kristyn Sanders, Shannon Lim, Sandra Ortega RN, Mark Gimbel and Lida Mina
Article Type: Case Report | First Published: February 07, 2019
Approximately after three months of exemestane therapy for breast cancer risk reduction, a 60-year-old female with estrogen receptor positive, right breast ductal carcinoma in situ (DCIS) presented to the emergency room with severe abdominal pain, nausea, vomiting, and diarrhea. Imaging studies revealed severe colitis of the transverse colon. No other medications were started except for exemestane that would have contributed to the patient's symptoms. Outpatient workup included stool cultures, laboratory studies, and esophagogastroduodenoscopy and colonoscopy with biopsies. Results of the stud...
Αβ-Crystallin and Laminin-332 are Prognostic Markers for Triple Negative Breast Cancers in a Brazilian Series
Marcia S Graudenz, Diego M Uchoa, Ermani Cadore, Juliana Giacomazzi and Sidia Maria Callegari-Jacques
Article Type: Research Article | First Published: February 01, 2019
Association between increased αβ-crystallin (ABC) and abnormal LN332 (LN332) expression in triple negative (TNBC) and basal-like (BLBC) breast cancers has been suggested recently. This study aims to evaluate ABC and LN332 immunohistochemical expression in a series of TN infiltrating ductal breast carcinomas and its association with clinical-pathological features and prognostic significance. Microarrays of 69 cases of TNBC cases were scored for the expression of ABC, LN332, CK5/6 and EGFR by immunohistochemistry with linked clinical and pathological data (age, tumor size, lymph node metastase...
High Prevalence of Hepatitis B Virus Infection among Pregnant Women Attending Antenatal Care in Central Nigeria
Peter Asaga Mac, Adamu Chipago Suleiman and Philomena Ehi Airiohuodion
Article Type: Original Research | First Published: January 30, 2019
A total of 200 pregnant women subjects were selected for this study to determine the sero-prevalence of hepatitis B virus (HBV) infection and assess the risk factors among pregnant women attending ante natal care at FMC, Keffi, Nigeria. A structured questionnaire was used for the data collection. Sera were collected and tested for hepatitis B surface antigen (HBsAg) and hepatitis B e antigen (HBeAg). The sero prevalence of HBV infection and its infectivity is high in Central Nigeria. This research article suggest the need for improved maternal health, routine immunization HBV screening among p...