Table 2: Univariate analysis of risk factors for in-hospital
deaths among surgical, critically ill patients with sepsis Results reported as
mean ± standard error.
|
Variables |
Hospital
Survivors |
Hospital
Non-survivors |
P-value |
|
|
(n
= 78) |
(n
= 25) |
|
|
Age (years) |
72.5 ± 1.4 |
71.7 ± 2.3 |
0.869 |
|
Gender (Male) |
47 (60.3%) |
18 (72.0%) |
0.347 |
|
Body weight (kg) |
52.1 ± 1.3 |
57.0 ± 3.6 |
0.299 |
|
Comorbidities |
|||
|
Diabetes mellitus |
11 (14.1%) |
4 (16.0%) |
0.755 |
|
Hypertension |
18 (23.1%) |
3 (12.0%) |
0.271 |
|
Heart failure |
4 (5.1%) |
5 (20.0%) |
0.036 |
|
Chronic renal failure |
9 (11.5%) |
0 (0.0%) |
0.109 |
|
Neoplasm |
21 (26.9%) |
9 (36.0%) |
0.450 |
|
Positive blood culture |
30 (38.5%) |
7 (28.0%) |
0.473 |
|
Localization of infection |
|||
|
Respiratory |
2 (2.6%) |
0 (0.0%) |
1.000 |
|
Heart |
1 (1.3%) |
0 (0.0%) |
1.000 |
|
Upper digestive tract |
11 (14.1%) |
2 (8.0%) |
0.730 |
|
Hepatobiliary-pancreas |
25 (32.0%) |
8 (32.0%) |
1.000 |
|
Lower digestive tract |
32 (41.0%) |
13 (52.0%) |
0.362 |
|
Urinary tract |
1 (1.3%) |
1 (4.0%) |
0.428 |
|
Soft tissue |
6 (7.7%) |
1 (4.0%) |
1.000 |
|
APACHE II score (points) |
14.0 ± 0.8 |
20.4 ± 2.0 |
0.002 |
|
SOFA score (points) |
5.0 ± 0.4 |
8.8 ± 0.8 |
< 0.0001 |
|
Body temperature (centigrade) |
37.6 ± 0.2 |
37.0 ± 0.3 |
0.145 |
|
Heart rate (/minute) |
101.8 ± 2.0 |
106.6 ± 4.9 |
0.508 |
|
Hematocrit (%) |
33.6 ± 0.8 |
35.1 ± 1.6 |
0.263 |
|
White blood cell count (/mm3) |
13920 ± 1184 |
15296 ± 9968 |
0.661 |
|
Platelet (×104/mm3) |
20.4 ± 1.3 |
17.2 ± 2.4 |
0.162 |
|
C-reactive protein (mg/dl) |
16.2 ± 1.3 |
14.4 ± 3.2 |
0.222 |
|
Total bilirubin (mg/dl) |
1.3 ± 0.1 |
2.3 ± 0.8 |
0.205 |
|
Serum creatinine (mg/dl) |
1.7 ± 0.2 |
1.9 ± 0.3 |
0.147 |
|
Fibrinogen (mg/dl) |
476.9 ± 30.9 |
351.0 ± 72.2 |
0.054 |
|
Prothrombin
activity (%) |
66.6 ± 2.7 |
55.2 ± 3.4 |
0.006 |
|
FDP (μg/ml) |
24.9 ± 3.7 |
62.2 ± 34.0 |
0.983 |
|
D-dimer (μg/ml) |
10.6 ± 1.5 |
17.4 ± 7.5 |
0.480 |
|
Surgical intervention |
66 (84.6%) |
18 (72.0%) |
0.234 |
Abbreviations:
APACHE II: Acute Physiology and Chronic Health Evaluation; SOFA: Sequential
Organ Failure Assessment; FDP: fibrinogen degradation products