Characteristics of studies evaluating the clinical value of PpIX fluorescence in identifying representative HGG tissue, as defined by neuroimaging ± histopathological criteria, in stereotactic biopsies or resections of suspected high-grade brain tumours.

Table 1: Characteristics of studies evaluating the clinical value of PpIX fluorescence in identifying representative HGG tissue, as defined by neuroimaging ± histopathological criteria, in stereotactic biopsies or resections of suspected high-grade brain tumours.

Study	Sample size	Sensitivity (%)	Specificity (%)	NPV (%)	PPV (%)
Piquer, et al. [20]	8	73	100	63	100
Widhalm, et al. [11]	33	100	80	100	91.9
Von Campe, et al. [21]	13	100	100	100	100
Widhalm, et al. [8]	26	88	89	91	85
Coburger, et al. [7]	34	91	80	22	99
Stummer, et al. [19]	33	-	-	39.5	96.2
Roessler, et al. [9]	10	-	-	-	100
Díez Valle, et al. [18]	36	92.2	92.3	66.6	98.6

PpIX: Protoporphyrin IX; HGG: High-grade gliomas (WHO grade  3); NPV: Negative Predictive Value; PPV: Positive Predictive Value; Lggs: Low-Grade Gliomas