Authors

Year

HA patients with Spontaneous ICH

Age

Presentation

Site of ICH

HA Severity

FactorActivity Level

Surgical Intervention

Initial Intervention

Regimen/Schedule

Outcome

Balak N, Silav G, Kiliç Y, Timur Ç, Elmaci I, [18]

2007

1

18 mo

Fever, Vomiting,

Hypersomnia

Right temporoparietooccipital SDH

Severe

2%

Craniotomy

Bolus of 500 IU of FVIII Concentrate

Maintenance with FVIII concentrate at 60 U/kg every 8 hours for 1 day,

then 60 U/kg every 12 hours for 7 days, and 60 U/kg every 24 hours for an additional 7 days

Normal neurological examination at the time of discharge

Bergin SM, Dunn AL, Smith LGF, Drapeau AI [20]

2019

1

14 wks

4 days of vomiting, Increase dirritability, Seizure with left eyed eviation in the Emergency department

Left lateral ventricle hematoma

Severe

ND

VP shunt

Bolus of 50 IU/kg of SHL rFVIII, CI of SHL Rfviii targeted to levels of 80%-120% + Prednisolone

Pre-op: Bolus 50 IU/kg; CI at 5 IU/kg/hr, target 100%-120%

Intra-op: CI target 80%-120%

Post-op: POD 0-7: CI w/target 80%-100%

POD 7-14: Bolus infusion every 12 hrs, Trough target ≥ 50%

POD 15-42: Bolus infusion every 24 hrs

At 6-months post-oppatient met developmental milestones, Displayed good visual tracking, and had noneurologicaldeficit

Bray GL, Luban NLC [21]

1987

1/3 Patients

5 wks

Rapidly increasing head size

Right superior cerebellar (IPH)

Severe

PTT: 42-100

Craniectomy

Intra-opp RBC, Platelets, FFP

Cryoprecipitate infusions consisting of 25 to 50 U/kg of FVIII every 6 to 8 hours for 14 days

Discharged hospital day 34 with neurological impairment

Cermelj M, Negro F, Schijman E, Ferro AM, Acerenza M, Pollola J [19]

2004

1

3 y/o

Fever, Vomiting, Headache

Left temporal SDH + Left temporal IPH

Severe

ND

Craniectomy

Bolus of 500 U (27 U/kg), Followed by a 60 U/kg/day CI of FVIII + Dexamethason

Pre-op: 15 U/Kg bolus

Intra-op: 117 U/Kg/day

Post op: CI FVIII at 50 U/kg/day for 10 days

Normal neurological exam 6 months after admission

Zakaria Z, Kaliaperumal C, Crimmins, D, Caird J [10]

2018

1/2 Patients

14 mo

48 hours of headache, Intermittentvomiting, Irritability, Left sided weakness, Seizure

Right Frontal IPH

Severe

< 1%

Craniotomy

Bolus of 500 U of factor VIII (Advate) intravenously + Dexamethasone

CI of FVIII concentrate (Advate) at 6 U/kg/hr

One month after discharge patient presented with right-sided weakness and bilateral papilledema. A CSF hygromacausinghydrocephalus was diagnosed. Required evacuation and VPS. Normal neurological exam 1 year later.

Hu Q, Zhang A, Liu AG, Wang SM, Wang YQ, Zhang LQ [11]

2018

4/13 Patients

Pt 1: 2y/o Pt 2: 2 y/o Pt 3: 6y/o Pt 4: 10 y/o

Pt 1: Fever, Convulsion, Gazing

Pt 2: Convulsion, Unconsciousness

Pt 3: Headache, Vomiting, Lethargy

Pt 4: Headache, Vomiting, Lethargy

Pt 1: Intracranial non-specified

Pt 2: Left temporal occipital region

Pt 3: SAH

Pt 4: ND

Allsevere

Pt1:.2%

Pt2:.9%

Pt3:1%

Pt4:.5%

ND

Recombinant FVIII: 40-50 U/kg per 12 h

40-50 U/kg/day upon symptom improvement. One week later, the dose was decreased to 20-25 U/kg/day, lasting for 10-14 days

There were no deaths during follow-up

Shrestha GS, Poudyal B, Bhattarai AS, Shrestha PS, Sedain G, Acharya N [22]

2014

1/2 Patients

19 y/o

Sudden onset loss of consciousnes and Anisocoria

Left intracerebral hematoma (IPH)

ND

ND

Craniotomy

FVIII 2500 units + Tranexamicacid 1 g

2000 Units of FVIII every 12 h for 3 days; 1250 units every 12 h for next 4 days; 750 units every 12 h for following 7 days. Tranexamicacid was continued at 500 mg 4 times daily for 15 days

Extubated POD 1 with GCS 15, discharged home POD 9

Yue CP, Mann KS [7]

1986

7/9 Patients

Pt 1: 2 mo Pt 2: 14 y/o Pt 3: 15 y/o

Pt 4: 16 y/o

Pt 5: 2 y/o Pt 6: 10 moPt 7: 3 y/o

Bulging fontanel (2/7), Headache (4/7), Hemiparesis (2/7), Dysphasia (1/7), Vomiting (1/7)

Pt 1: Right frontal SDH

Pt 2: Left frontal temporal SDH

Pt 3: Left occipital SDH

Pt 4: Left frontoparietal SDH

Pt 5: Left Parietal-occipital Epidural hematoma

Pt 6: Left frontal SDH

Pt 7: Left hemispheric SDH

All severe (7/9)

All < 1%

All craniotomies

Body weight (kg) × Desired factor VIII (% normal)/ 2

Repeat infusion every 8 hrs with an additional dose prior to surgery. Target activity 100% POD 1-3

50% POD 4th-10th.

Good recovery reported at 6 months