Table 6: Examples of events likely to occur and their influence on oxidative stress.
Disease, syndrome or treatment | Main consequences |
Inflammation | WBC production of ROS, increased energy needs |
Clotting | O2 and energy consumption, increased glycolysis and proteolysis, inflammation |
Atherosclerosis | Increased lipid metabolism, ischemia |
Diabetes | Increased polyol pathway, proteins glycation |
Ischemia | Mitochondrial dysfunction, lipid peroxydation, arachidonic acid catabolism, inflammation |
Cancers | Toxic agents, ischemic areas, increased metabolic needs, inflammatory responses |
Chemo or radiotherapy | Cytolysis, release of ROS, impairment of food intake |
Surgery | Tissue inflammation, ischemia, foreign materials Ischemia reperfusion, healing process |
Anesthetics | Renal or hepatic toxicity, cell repair, variations of pO |