Table 1: Inclusion and exclusion criteria.
Criteria | To include | To exclude |
Study designs |
All quantitative study designs Case Report Randomized Controlled Trials Crossover Trials Clinical Trial (Not Randomized) Cohort Systematic Review Meta-analysis Conference Proceedings |
Opinion Pieces Conference Proceedings |
Population characteristics |
Human subjects Adult ( ≥ 18 yrs) diagnosed with: • HTN (BP > 130/mmHg) • OSA (mild OSA or greater, AHI > 5) All races/ethnicities Male & Female |
Non-human subjects Persons < 18-years-old Pregnant Women Populations with CKD, poorly controlled DM HF, MI, unstable angina, stroke |
Intervention |
Evening administration of antihypertensive medication (6:00 p.m. to 12:00 midnight) vs.morning administration of antihypertensive medication (6:00 a.m. to 12:00 noon) or vs. placebo groups |
Morning only or non-time specific medication administration. Chronotherapy for conditions other than HTN. |
Outcomes assessed |
Primary outcome: Change from baseline 24-hour mean SBP and DBP measured by: • Office BP measurement OR • Ambulatory BP monitoring OR • Asleep BP measurement • Dipping pattern Characterization • CV morbidity and mortality Secondary outcome: • Adverse drug events • OSA occurrence (AHI or similar scoring system) |
|
Year Performed | No start date limitation - January 19, 2018 |
*HTN: Hypertension; OSA: Obstructive Sleep Apnea; CKD: Chronic Kidney Disease; DM: Diabetes Mellitus; HF: Heart Failure; MI: Myocardial Infarction; SBP: Systolic BP; DBP: Diastolic BP; BP: Blood Pressure; CV: Cardiovascuar; OSA: Obstructive Sleep Apnea; AHI: Apnea-Hypopnea Index.