Table 3: Pregnancy outcomes in 129 women with systemic sclerosis after the disease onset according to ATA positivity.

Events after disease onset

No. of events:

total No. of Topo+ (%)

No. of events:

total No. of Topo - (%)

OR (95% CI)

P-value

Pregnancies

 

 

Gravid women

22:66 (33.3)

9:30 (30.0)

1.22 (0.76 - 4.65)

P = 0.67

Gravidity

34:76 (44.7)

10:31 (32.0)

1.70 (0.48 - 3.11)

P = 0.24

Pregnancy outcomes

 

 

 

 

Women with abortion

5:66 (7.50)

3:30 (10.0)

0.73 (0.164 - 3.31)

P = 0.69

No. of abortions

11:72 (16.4)

3:30 (10.0)

1.62 (0.42 - 6.29)

P = 0.48

Women with RPL

3:66 (4.55)

0:30

3.31 (0.16 - 66.1)

P = 0.43

No. of RPL

9:72 (12.5)

0:30

8.98 (0.50 - 159.4)

P = 0.13

No. of spontaneous abortions

11:72 (15.0)

2:30 (6.70)

2.02 (0.42 - 9.71)

P = 0.37

No. of therapeutic abortions

0:66

1:30

0.15 (0.01 - 3.74)

P = 0.24

Women with delivery

20:66

6:30

1.74 (0.62 - 4.90)

P = 0.29

No. of deliveries

23:69

7:31

 

 

Twin pregnancy

0

0

NOT APPLICABLE

-

Women with term delivery

15:66 (22.7)

6:30 (20.0)

1.17 (0.41 - 3.41)

P = 0.76

No. of term deliveries

18:69 (23.1)

7:31 (22.5)

1.21 (0.45 - 3.30)

P = 0.70

Women with preterm delivery

5:66 (7.5)

0:30

5.45 (0.29 - 101.90)

P = 0.25

No. of preterm deliveries

5:66 (7.5)

0:30

5.45 (0.29 - 101.90)

P = 0.25

Women with stillbirth

1:66 (1.5)

0:30

1.39 (0.05 - 35.29)

P = 0.83

Number of stillbirths

2:66 (3.0)

0:30

2.36 (0.11 - 50.77)

P = 0.58

Women with unsuccessful pregnancy

3:66 (4.5)

2:30 (6.6)

0.66 (0.10 - 4.21)

P = 0.66

Delivery mode

Number of NVD

10:68 (14.7)

4:31 (12.9)

1.16 (0.33 - 4.05)

P = 0.81

Number of caesarian sections

13:60 (21.6)

3:30 (10)

2.20 (0.57 - 8.41)

P = 0.24

Obstetric complications

Gestational hypertension

0

0

NOT APPLICABLE

-

Women with preeclampsia

0

0

NOT APPLICABLE

-

No. of preeclampsia

0

0

NOT APPLICABLE

-

Newborn outcomes

Women with very low birth weight infants (< 1500 g)

2:66 (3.0)

0:30

2.36 (0.11 - 50.77)

 

No. of neonatal deaths

0

0

NOT APPLICABLE

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

# No. (%): Number (percentage); *TOPO+: Anti-Topoisomerase 1 positivity; **TOPO-: Anti-Topoisomerase 1 Negativity; OR (CI95%): Odds Ratio (confidence interval); ŧ NA: Not Applicable.