Table 2: Pregnancy outcomes in 109 women according to disease subset and disease onset in systemic sclerosis.

 

All patients

dcSSc

#N0 (%)

*lcSSc

N0 (%)

0R (CI 95% CI)

P-value

After Disease onset

N0 (%)

Before disease onset

N0 (%)

OR (CI 95%)

P-valve

Pregnancies

Women with pregnancy

109

52

57

-

-

18

71

-

-

No. of pregnancies

278

123

155

-

 

49

229

-

-

PREGNANCY OUTCOME

 

 

 

 

 

 

 

 

 

Women with abortion

32 (29)

9 (17)

23 (40)

0.30 (0.1268 - 0.75)

0.01

8:18 (44)

24:71 (34)

1.56 (0.54 - 4.48)

0.40

Women with RPL

10 (9)

3 (5.7)

7 (12.2)

1.20 (0.27 - 5.24)

0.80

2 (11)

8 (11)

0.64 (0.12 - 3.34)

0.59

No. of abortions

46 (16.5)

14 (11.3)

32 (21)

0.49 (0.25 - 0.97)

0.04

14 (29)

32 (14)

2.46 (1.19 - 5.07)

 0.01

No. of spontaneous abortions

34 (12.2)

11 (8.9)

23 (14.8)

0.56 (0.26 - 1.20)

0.14

13 (26.5)

22 (9.6)

3.05 (1.39 - 6.69)

0.005

No. of therapeutic abortions

12 (4.3)

3 (2.4)

9 (5.8)

0.41 (0.10 - 1.53)

0.18

1 (2)

10 (4.3)

0.93 (0.19-4.39)

0.92

Women with delivery

102 (93.5)

49 (94.2)

53 (93.0)

3.36 (0.66 - 16.98)

0.14

12 (67.0)

70 (98.0)

0.02 (0.003 - 0.25)

0.001

No. of deliveries

227 (81.6)

107 (87.0)

120 (77.0)

2.17 (1.14 - 4.12)

 0.10

33 (67.0)

191 (83.3)

0.41 (0.20 - 0.81)

0.01

Twin pregnancy

1 (0.4)

0

1 (0.7)

0.42 (0.01 - 10.41)

0.52

1 (2)

0

14.19 (0.56 - 353.74)

0.10

Women with term delivery

99 (91.0)

49 (94.2)

50 (87.7)

0.28 (0.55 - 9.35)

0.24

11 (6.1)

70 (98.5)

0.02 (0.002 - 0.23)

0.001

No. of term delivery

214 (77.0)

100 (81.3)

114 (73.5)

1.56 (0.87 - 2.78)

0.12

27 (55.1)

187 (81.6)

0.27 (0.14 - 0.53)

0.0001

Women with preterm delivery

17 (15.6)

9 (17.3)

8 (14.0)

1.28 (0.45 - 3.61)

0.63

8 (44.4)

9 (12.6)

5.51 (1.72 - 17.63)

0.004

No. of preterm deliveries

18 (6.5)

9 (7.3)

9 (5.8)

1.28 (0.49 - 3.33)

0.61

8 (16.3)

10 (4.3)

4.76 (1.73 - 13.08)

0.002

Women with stillbirth

5 (4.6)

1 (1.9)

4 (7.0)

0.25 (0.02 - 2.31)

0.22

2 (11.1)

3 (4.2)

0.96 (0.155 - 5.99)

0.96

No. of stillbirths

5 (1.8)

1 (0.8)

4 (2.5%)

1.26 (0.07 - 20.38)

0.86

2 (4.1)

3 (1.3)

3.20 (0.52 - 19.71)

0.20

Unsuccessful pregnancy

7 (2.5)

2 (1.6)

5 (3.2)

0.41 (0.07 - 2.24)

0.30

6 (12.2)

1 (0.4)

35.00 (3.86 - 317.08)

0.001

Delivery mode

Number of normal vaginal delivery

166 (60.0)

73 (59.0)

93 (60)

0.97 (0.60 - 1.57)

0.91

17 (34.6)

149 (65.0)

0.28 (0.15 - 0.54)

0.0001

Number of caesarian sections

66 (24.0)

34 (27.6)

32 (21)

1.46 (0.84 - 2.55)

 0.17

18 (36.7)

48 (21.0)

2.18 (1.12 - 4.24)

0.02

Obstetrics complications

Gestational hypertension

1 (0.4)

0

1 (0.7)

0.42 (0.01 - 10.41)

0.52

0

1 (0.4)

1.53 (0.06 - 38.33)

0.79

No. of preeclampsia

3 (1.1)

2 (1.6)

1 (0.7)

2.54 (0.22 - 28.4)

 0.44

2 (4.1)

1 (0.4)

9.70 (0.81 - 109.2)

0.06

Newborn outcomes

No. of live births

228 (82.0)

107 (87.0)

121 (78.0)

2.17 (1.14 - 4.12)

 0.10

33

191

0.41 (0.20 - 0.81)

0.01

Women with very low birth weight infants (< 1500 g)

4 (3.1)

1 (1.9)

3 (5.2)

0.35 (0.03 - 3.50)

 0.37

2 (11.1)

2 (2.81)

4.31 (0.56 - 32.9)

0.15

No. of women with very low birth weight infants (< 1500 g)

5 (1.7)

1 (0.8%)

4 (2.5%)

0.31 (0.03 - 2.82)

0.29

3 (6.1)

2 (1)

7.40 (1.20 - 45.55)

0.03

Women with neonatal death

3 (2.7)

1 (1.9)

2 (3.5)

0.53 (0.04 - 6.12)

0.61

1 (5.5)

2 (2.81)

2.02 (0.17 - 23.71)

0.57

No. of neonatal death

4 (1.4)

1 (0.8)

3 (1.9)

0.41 (0.04 - 4.04)

0.44

1 (2)

3 (1.3)

1.56 (0.15 - 15.41)

 0.69

 

dsSSc: Diffuse Cutaneous Systemic Sclerosis; #No (%): Number (percentage); *lcSSc: Limited Cutaneous Systemic Sclerosis; OR (CI): Odds Ratio (confidence interval).