Causes for MTX toxicity in each case.

Table 3:Causes for MTX toxicity in each case.

No	age [y]	disease	MTX-dosage[mg/w]	Reason of toxicity	GFR before[ml/min]	Minimal GFR[ml/min]	Cofactors	Relevant comedication	Toxicity	Outcome
1	57	RA	150	Dose error	90	90			Pancytopenia, mucositis,pneumonia	Died
2	73	RA	15	ARF on CRF II	72	40		LEF, ARB	Leukopenia,thrombocytopenia	Recovery
3	43	RA	105	dose error	90	90	Previous diarrhea		Pancytopenia,mucositis	Recovery
4	53	pSS	15	ARF	68	20	Unkown LCDD		Pancytopenia	Recovery
5	66	PS	12.5	CRF IV	29	27		ARB, LD	Leucopenia,mucositis	Recovery
6	75	RA	15	CRF IV	28	24	Use of painkiller	ACE	Pancytopenia, mucositis,pneumonia	Died
7	79	RA	15	ARF on CRF II	65	37	Diarrhea (Noro-Virus)	NSAID, ACE	Pancytopenia	Recovery
8	54	RA	15	ARF on CRF Ill	58	36	Acute interstitial nephritis		Pancytopenia, mucositis	Recovery
9	55	RA	15	ARF	92	36		ACE	Leucopenia, anemia, pneumonia	Recovery
10	82	RA	15	ARF on CRF Ill	55	24			Pancytopenia, mucositis,fever,soor esophagitis	Recovery
11	71	AAV	15	ARF on CRF Ill	59	43	Infection with fever	ARB, HCT	Pancytopenia,mucositis,pneumonia	Recovery
12	78	RA	15	ARF on CRF 111	53	21			Pancytopenia, pneumonia	Recovery
13	83	RA	15	ARF on CRF Ill	51	32		ARB	Pancytopenia	Recovery
14	64	RA	70	dose error	90	90	Urinary retention		Pancytopenia	Recovery
15	84	RA	7.5	ARF on CRF II	66	15	Infection with fever	ACE, COX	Pancytopenia,mucositis,diarrhea	Recovery
16	66	RA	15	ARF	90	31		ACE, TOC	Pancytopenia	Recovery
17	68	PSA	15	unclear	90	90	Acute interstitial nephritis	LEF	Panzytopenia, mucositis	Recovery
18	78	pSS	15	ARF on CRF Ill	55	38	Previous diarrhea		Pancytopenia	Recovery
19	61	RA	15	ARF	90	10		ARB, NSAID, HGT	Pancytopenia	Recovery
20	62	RA	30	ARF on CRF II and dose error	83	54	Previous diarrhea	LEF, NSAID	Pancytopenia, mucositis, pneumonia	Recovery
21	72	PS	22.5	CRF IV	28	27		LD	Leucopenia,thrombocytopenia,mucositis	Recovery
22	89	RA	90	CRF IV and dose error	20	18			Pancytopenia, mucositis, pneumonia	Died

ARF: acute renal failure, CRF (2-4): chronic renal failure (stage 2-4), LCDD: light chain deposition disease, Medication: LEF: leflunomide, TOC: tocilizumab,

ARB: angiotensin receptor blocker; ACE: ACE-inhibitor, LD: loop diuretics, HCT: hydrochlorothiazide, NSAID: nonsteroidal antiinflammatory drugs, COX: cyclooxygenase II-inhibitor.