| Body System Affected | Symptoms |
| Highly Suspicious Sx | |
| General Physical appearance | Characteristic facial features |
| Respiratory, eyes, ears, nose and throat | Hearing loss |
| Corneal clouding | |
| Cardiac | Cardiac manifestations |
| Bones and joints | Dysostosis multiplex |
| GI | Hepatosplenomegaly |
| Neurologic | Spinal cord compression |
| Hydrocephalus | |
| Carpal tunnel syndrome | |
| Delayed mental development or | |
| regression in mental development | |
| Less Suspicious Sx | |
| General Physical appearance | Short stature |
| Extensive Mongolian spots | |
| Respiratory, eyes, ears, nose and throat | Sleep apnea |
| Copious nasal discharge | |
| Recurrent Otitis media, EOM or myringotomy | |
| Frequent URI | |
| Bones and joints | Joint stiffness or limited ROM |
| Hand problems | |
| Gastrointestinal | Hernia |
| Dental | Abnormally shaped teeth |
| Dental cysts/abscess |