Table 1: High vs less suspicious symptoms

Body System Affected Symptoms
Highly Suspicious Sx
General Physical appearance Characteristic facial features
Respiratory, eyes, ears, nose and throat Hearing loss
Corneal clouding
Cardiac Cardiac manifestations
Bones and joints Dysostosis multiplex
GI Hepatosplenomegaly
Neurologic Spinal cord compression
Hydrocephalus
Carpal tunnel syndrome
Delayed mental development or
regression in mental development
Less Suspicious Sx
General Physical appearance Short stature
Extensive Mongolian spots
Respiratory, eyes, ears, nose and throat Sleep apnea
Copious nasal discharge
Recurrent Otitis media, EOM or myringotomy
Frequent URI
Bones and joints Joint stiffness or limited ROM
Hand problems
Gastrointestinal Hernia
Dental Abnormally shaped teeth
Dental cysts/abscess