Table 4: Psychopharmachological treatment
after surgery.
Author
and Publication year |
Country |
Study
features |
N
Participants |
Mean
age |
Sex |
Other features of the study |
Surgery/setting |
Instruments |
Results |
Roerig
et al. 2013 [57] |
Fargo,
USA |
Observational
study |
10
patients, 10 controls |
|
|
To determine to what extent the RYGB procedure
alters the area under the plasma concentration/time curve (AUC) of the
antidepressant, duloxetine (60 mg/die): 1 year post-RYGB |
RYGB |
Nineteen plasma samples were obtained
during 72 hours to characterize the plasma level profile. |
The bariatric surgery group was exposed to
only 57.7% of duloxetine as compared to the nonsurgery
group. |
Roerig
et al. 2012 [28] |
Fargo,
USA |
Observational
study |
5
patients, 5 controls |
|
|
To determine to what extent RYGB alters the area
under the plasma concentration/time curve (AUC(0-10.5))
of the antidepressant, sertraline (100 mg /die). |
RYGB |
Plasma samples were obtained for 10.5 hours. |
The mean AUC(0-10.5) and the
maximal plasma concentration were significantly smaller for
the postbariatric surgery group
(compared with the nonsurgical control group. |
Hamad
GG et al. 2012 [58] |
Pittsburgh,
USA |
Prospective, longitudinal study, 6- 12- months
follow up |
12 |
41.9 |
11
F, 1 M |
Timed blood samples for SRI plasma levels were drawn
for pharmacokinetic studies before surgery and 1, 6, and 12 months afterward.
Maximum concentration, time to maximum concentration, and area under the
concentration/time curve (AUC) were determined. |
RYGB |
SCID-IV; Structured Interview Guide for the Hamilton
Depression Rating Scale–Atypical Depression Symptom Version (SIGH-ADS) |
AUC values 1 month after surgery dropped to an
average of 54% of preoperative levels;
in 6 of these patients, AUC values returned to baseline levels (or greater)
by 6 months. 4 patients had an exacerbation of depressive symptoms, which
resolved by 12 months in three of them. 3 of the four patients had a reduced
AUC level at 1 month and either gained weight or failed to lose weight
between 6 and 12 months. |
Tripp
AC et al. 2011 [101] |
Pittsburgh,
USA |
Case
report |
1 |
51 |
M |
Treatment with Lithium at therapeutic dose |
RYGB |
|
Alterations in drug dissolution and absorption as
result of RYGB |
F:
Female; M: Male; BS: Bariatric Surgery; BMI: Body mass Index; RYGB:
Roux-Y-Gastric Bypass; LAGB: Laparoscopic Adjustable Gastric Banding; MDD:
Major Depressive Disorder; BD: Bipolar Disorder; BED: Binge Eating Disorder;
SCID-I: Structured Clinical Interview for DSM IV Axis I disorders; Ham-D:
Hamilton Rating Scale for Depression; BDI: Beck Depression Inventory; Beck
Depression Inventory-II (BDI-II); QoL: Quality of
Life