Table 2: Prevalence
of affective disorders after surgery.
Author and Publication year |
Country |
Study features |
N Participants |
Mean age |
Sex |
Other features of
the study |
Surgery/setting |
Instruments |
Results |
Ivezaj V & Grilo Cm 2015 [45] |
New Haven (CT-USA) |
Prospective, longitudinal study |
107 |
|
94 F; 13M |
To evaluate the frequency
of bariatric patients who experienced
discernible increases in depression
levels following surgery and explored their correlates. 6- 12-
months follow up |
RYGB |
BDI; Eating Disorder
Examination EDE-Q; Self-esteem (RSES), Social functioning (SF-36) |
14 (13.1 %) participants
reported discernible increases (BDI-Increase), 14 (13.1 %)
reported discernible decreases (BDI-Decrease), and 79 (73.8 %) did not
report discernible changes (no change) in BDI scores from 6 to 12 months
postsurgery.
By 12 months postsurgery, the
BDI-Increase group had significantly higher depression scores. |
Nepal H et al.
2015 [47] |
Springfield (IL-USA) |
Case report |
1 |
57 |
F |
One of complications after
bariatric surgery is represented by neuropsychiatric disorders and psycho-behavioral symptoms. Onset 2 monts after
surgery. |
RYGB |
Psychiatric evaluation, clinical interview |
Primary mania. |
Ahmed AT et al.
2013 [60] |
San Francisco (USA) |
Prospective, longitudinal study |
144 patients with bipolar
disorder who underwent BS and 1440 controls |
43.9+/-10 |
88.9% F, 11. 1%M |
To determine if bariatric
surgery alters psychiatric course among stable patients with bipolar disorder |
Bariatric surgery |
Psychiatric hospitalization:
defined as any inpatient stay at a psychiatric hospital. |
9% BS and 10.6% unexposed to
surgery had psychiatric hospitalization during follow-up. |
Cunningham JL et
al. 2012 [46] |
|
Retrospective study |
439 |
|
|
Antidepressant usage after sugery |
RYGB |
|
23% increase antidepressant,
40% same antidepressant, 18% change, 16% decrease or discontinued
antidepressant. |
de Zwaan et al.
2011 [38] |
Nuremberg, Germany |
Prospective, longitudinal study |
107 |
37.5 +/- 9.7 |
32 M; 75 F |
Assessment after 6-12 months
and 24-36 months. |
Bariatric surgery |
SCID -I |
The point prevalence of
depressive disorders but not of anxiety disorders decreased significantly
after surgery. Patients with both depressive and anxiety disorders at
baseline (current and lifetime) lost significantly less weight after surgery.
Postoperative depressive disorder was negatively associated with weight loss
at the 24–36 month follow-up assessment point. |
Hayden et al. 2011
[40] |
Victoria, Australia |
Prospective, longitudinal study |
191 |
41+/-9 |
|
Assessment at baseline and
after 12 months |
LAGB |
BDI |
Patient scores on the negative
self-attitude subscale were significantly greater than the two other
subscales and showed the greatest improvement 1 year following LAGB. |
Sultan et al.
2009 [41] |
New York |
Prospective, longitudinal study |
53 |
46.9 |
|
BMI lower than 35, follow up 2
years. Study parameters included preoperative age, gender, BMI, presence of
comorbidities, percentage of excess weight loss (%EWL), and resolution of
comorbidities. |
LAGB |
|
Substantial improvement
occurred for the following comorbidities evaluated: hypertension, depression,
diabetes, asthma, hypertriglyceridemia, obstructive sleep apnea,
hypercholesterolemia, and osteoarthritis. |
Segal JB et al.
2009 [29] |
Baltimore (USA) |
Retrospective study |
6235 |
44 |
M/ F (F = 82%) |
To compare the mean number
of medications at the time of surgery and in the
subsequent year |
RYGB, Gastroduodenostomy |
|
Decrease in the mean number of
prescriptions filled for antidepressant medications, with a 9% decrease by
12-months. |
Schowalter et al. 2008 [42] |
Wuerzburg, Germany |
Prospective, longitudinal study |
248 |
|
|
128 patients were treated with
gastric banding and 120 controls |
LAGB |
BDI |
In the preoperative assessment,
35% of all obese patients suffered from clinically relevant depressive
symptoms. After 5 to 7 years, patients with gastric banding improved
significantly in depression, whereas no change was found in patients without
gastric banding. |
Burgmer et al.,
2007 [39] |
Dortmund, Germany |
Prospective, longitudinal study |
149 |
38.8 ± 10.3 |
47 M; 102 F |
To evaluate depressive
symptoms, self-esteem and health-related quality of life 2 years after
bariatric surgery. |
Gastric restrictive surgery |
|
Pre-surgery, 40.5% (n=62) of
the patients suffered from depressive symptoms of clinical relevance. These
depressive symptoms persisted in 17.7% (n = 27) 1 year and in 16.4% (n = 25)
2 years after surgery. |
Emery et al.
2007 [43] |
Columbus (USA) |
Prospective, longitudinal study |
13 |
46.9 ± 5.7 |
F |
To examine the relationship of
inflammation and depression among gastric bypass patients in a 12-month
longitudinal study. |
RYGB |
Self-report measures of
depression |
Significant reductions in BMI,
participants experienced significant reductions in C-reactive protein (CRP),
IL-6, and depressive symptoms. Decreased depression during the 12-month
follow-up was highly correlated with reduced CRP. |
Dixon et al.
2003 [3] |
Melbourne, Australia |
Prospective, longitudinal study |
487 |
41.2 ± 9.7 |
M (15%)/ F |
To examine depression before
and after surgically induced weight loss. |
LAGB |
BDI |
Weight loss was associated with
a significant and sustained fall in BDI scores, with a mean +/- SD score of
7.8 +/- 6.5 at 1 year and 9.6 +/- 7.7 at 4 years after surgery. Greater falls
in BDI score at 1 year were seen in women, younger subjects, and those with
greater excess weight loss. |
Kaltsounis et al. 2000 [26] |
|
Case report |
1 |
27 |
M |
To report the use of intra-
venous valproate sodium for the treatment of severe manic symptoms that
developed after gastric bypass surgery |
RYGB |
Monitoring during hospedalization; C linician-Administered Rating Scale for Mania (CARS-M) |
Intravenous valproate was
initiated conservatively at approximately 4 mg/ kg every 60 minutes. Intravenous
administration of valproate seemed to be efficacious, well tolerated, and pharmacokinetically appropriate. |
F: Female; M: Male; BS:
Bariatric Surgery; BMI: Body mass Index; RYGB: Roux-Y-Gastric Bypass; LAGB:
Laparoscopic Adjustable Gastric Banding; MDD: Major Depressive Disorder; BD:
Bipolar Disorder; SCID-I: Structured Clinical Interview for DSM IV Axis I
disorders; BDI: Beck Depression Inventory; Beck Depression Inventory-II (BDI-II)