Table 1: Clinical and histopathological differences between chondroblastoma, giant cell tumor and clear cell chondrosarcoma [7,14-17].

Chondroblastoma Giant Cell Tumor of Bone Clear Cell Chondrosarcoma
Clinical Features

- Epiphyseal, but could extend to metaphysis

- 2nd-3rd decade

- Secondary aneurysmal bone cyst possible

- Usually metaphyseal

- Ages 20-40

- Peripheral eggshell calcification

- Secondary aneurysmal bone cyst possible

- Epiphyseal

- Very similar to chondroblastoma

- Secondary aneurysmal bone cyst possible


- S-100 positive (negative result does not exclude diagnosis)

- Reticular "chicken wire" calcification

- Linear nuclear grooves

- Chondroid matrix; patchy, scattered osteoclastic giant cells

- S-100 negative

- Osteoclastic giant cells contain large number of nuclei

- Diffuse distribution of stromal cells and giant cells

- Nuclei of mononuclear cells identical to those of giant cells

- S-100 positive

- Faintly lobulated

- Abundant clear & eosinophilic cytoplasm, sharp cell borders, larger nuclei

- Fewer, scattered osteoclastic giant cells

- Cells mixed with reactive bone