Table 2: Effect of inhibitors doxycycline and ECGC with and without PMA treatment on laryngeal squamous cell carcinoma (FaDu) and tongue cancer cells (SCC-25).

Larygneal squamous cell carcinoma (FaDu) Tongue cancer cells (SCC-25)
MMP-2 (%) MMP-9 (%) MMP-2 (%) MMP-9 (%)
Doxycycline (μM)
Control 7.1 7.5 12.4 14.1
10 - - 15.9 20.2
25 6.6 22.3 6.5 13.8
50 0 53.7 0.6 12.2
100 0 2.8 0.3 4
Doxycycline (μM) with PMA (100 ng/ml)
Control 0.2 0.3 - -
10 - - - -
25 0.1 87.6 - -
50 0 11 - -
100 0 0.1 - -
EGCG (μg/ml)
Control 2.3 5 16.1 13.7
10 - - 22.1 31.5
25 3.1 15.2 10.4 4.8
50 1.5 42.6 0.4 1
100 0 96 0 0
EGCG (μg/mL) with PMA (100 ng/ml)
Control 0.2 0.4 9.9 38.7
10 - - 1.5 21
25 0.4 53.7 0.4 15.4
50 0.2 43.5 0 5.1
100 0 0.9 3.9 4