Parameter

Baseline

Day 7

Change Baseline-day 7. (^*day 2-baseline)

P value

Top: Day 7-baseline

Bottom: Difference between arms at day 7

Inflammatory markers

ESR

Study Total

12.8

11.4

1.37

0.0025^*

IVM

12.9

10.98

1.88

0.257

IVM+

12.7

11.91

0.86

C-reactive Protein

Study total

14.7

5.6

9.00

< 0.0001^*

IVM

14.7

5.9

6.9

0.743

IVM+

14.7

5.4

7.4

D-Dimer FEU

Study total

221.8

171.2

50.55

< 0.0001^*

IVM

223.9

164.5

59.4

0.221

IVM+

220.6

178.1

41.7

Hematology

Hemoglobin

Study Total

12.7

12.1

0.56

0.138

IVM

12.9

12.3

0.67

0.615

IVM+

12.6

12.1

0.44

WBC

Study Total

9.5

7.9

1.62

0.0002^*

IVM

9.8

8.0

1.75

0.75

IVM+

9.3

7.8

1.49

Lymphocytes

Study total

34.9

33.5

1.3

0.322

IVM

32.4

32.7

-0.27

0.233

IVM+

37.3

34.4

2.2

Neutrophils

Study total

59.2

51.8

7.31

0.0006^*

IVM

58.6

51.7

6.9

0.838

IVM+

59.8

52.1

7.7

Neutrophil to Lymphocyte ratio (NLR)

Study total

1.70

1.55

0.15

0.9102

IVM

1.81

1.58

0.23

0.499

IVM+

1.60

1.52

0.08

Platelet count × 10⁹/liter

Study total

204.1

153.8

49.7

< 0.0001^*

IVM

211.5

148.8

62.7

0.155

IVM+

197

158.7

36.8

Viral Cycle threshold (Ct)

N-Gene

Study total

26.5

33.8

7.04^*

< 0.0001^*

IVM

27.4

33.7

6.42^*

0.425

IVM+

25.7

33.8

7.68^*

E-gene Viral Cycle Time

Study total

20.9

28.6

7.62^*

< 0.0001^*

IVM

21.2

27.8

6.53^*

0.133

IVM+

20.7

29.5

8.71^*

SpO₂

Study total

92.9

97.7

4.78

< 0.0001^*

IVM

93.8

97.8

3.5

0.0189^*

IVM+

92

97.5

6