Table 2: Severity scores, stay, clinical respond, and outcomes in Ceftaroline group versus another antibiotic.
|
Ceftaroline (N = 34) (28.1%) |
Another Antibiotic (N = 87) (71.9%) |
p |
Severity of clinical presentation |
|
|
|
SOFA at admission |
7.6 ± 2.9 |
5.6 ± 3.01 |
0.001 |
FINE |
4.4 ± 0.7 |
3.6 ± 1.2 |
0.001 |
Stay |
|
|
|
Stay in ICU (days) |
18.9 ± 15.5 |
9.4 ± 12.8 |
0.001 |
Stay in hospital (days) |
28.9 ± 20.4 |
17.01 ± 19.1 |
0.003 |
Clinical response |
|
|
|
Cure criteria: End of treatment |
33 (97.1%) |
66 (75.9%) |
0.007 |
Clinical improvement in 72 hours |
28 (82.4%) |
47 (54%) |
0.004 |
Mortality |
|
|
|
Hospital death |
6 (17.6%) |
22 (25.3%) |
0.370 |
Early death (< 3 days) |
1 (25%) |
8 (36.4%) |
0.660 |
Death at 30 days |
3 (75%) |
12 (80%) |
0.827 |
Related Mortality |
0 |
12 (63.2%) |
0.007 |
Another group includes treatment with ceftriaxone, piperacillin-tazobactam, cefepime or cloxacillin. Quantitative data are expressed like median ± standard deviation and categoric data like percentage; SOFA: Sequential Failure Assessment Score; ICU: Intensive care unit.