Table 1: Basal data, comorbidity, initial clinical and microbiological data in patients with Ceftaroline and another antibiotic.

 

Ceftaroline

(N = 34) (28.1%)

Another Antibiotic

(N = 87) (71.9%)

p

Sex male

20 (58.8%)

65 (74.7%)

0.09

Age (years)

55.1 ± 15.5

63.1 ± 15.2

0.01

Institutionalized

0

4 (4.6%)

0.204

Comorbidity

 

 

 

Smoke

12 (35.3%)

21 (24.1%)

0.216

Diabetes mellitus

8 (23.5%)

18 (20.7%)

0.732

Alcohol abuse

0

4 (4.6%)

0.204

Neoplasm

3 (8.8%)

2 (2.3%)

0.105

COPD

7 (20.6%)

21 (24.1%)

0.677

Asthma

2 (5.9%)

0

0.023

Chronic hepatopathy

4 (11.8%)

7 (8%)

0.522

Corticoids

2 (5.9%)

11 (12.6%)

0.280

Immunosuppressor therapy

2 (5.9%)

6 (6.9%)

0.840

Initial data in ICU

 

 

 

Type of sepsis

 

 

 

Sepsis

8 (23.5%)

43 (49.4%)

 

Septic shock

26 (76.5%)

44 (50.6%)

0.01

Mechanical Ventilation

22 (64.7%)

35 (40.2%)

0.01

Vasoactive drugs

28 (82.4%)

44 (50.6%)

0.001

Procalcitonin (ng/ml)

23.6 ± 28.5

11.8 ± 23.6

0.025

Procalcitonin at third day (ng/ml)

6.9 ± 7.2

6.4 ± 11.1

0.803

ICU associated treatment

 

 

 

Macrolide

18 (90%)

22 (45.8%)

0.001

Quinolone

13 (86.7%)

57 (78.1%)

0.453

Corticoids

9 (26.5%)

27 (31.4%)

0.596

Microbiological data

 

 

 

Positive blood culture

14 (41.2%)

8 (9.4%)

< 0.001

Positive Bronquial secretion culture positivo

7 (20.6%)

12 (13.8%)

0.356

Positive urine Antigens

16 (47.1%)

18 (20.7%)

0.004

Results

 

 

 

Pneumococcus

17 (50%)

18 (20.7%)

 

Others

4 (11.8%)

22 (25.3%)

 

Negative

13 (38.2%)

47 (54%)

0.005

Another antibiotic group includes treatment with ceftriaxone, piperacillin tazobactam, cefepime or cloxacillin. Quantitative data are expressed like median ± standard deviation and categoric data like percentage. COPD: Chronic obstructive pulmonary disease; ICU: Intensive care unit [2].