Table 3d: Cephalosporins

Ceftaroline 2010

• Fifth-generation cephalosporin with extended Gram-positive activity.

• Only FDA approved cephalosporin with activity against VISA, VRSA and linezolid- and daptomycin-resistant S. aureus [49].

• Approved for the treatment of acute bacterial SSSIs and community-acquired pneumonia.

• Demonstrates excellent affinity for prominent PBPs that are used by resistant strains [49-50].

• Synergy with carbapenems, azactams and some aminoglycosides.

• Low probability of developing resistance.

• Favorable safety and tolerability profile.