Timeline of Staphylococcus aureus antibiotic resistance [11].

Table 1: Timeline of Staphylococcus aureus antibiotic resistance [11].

Antibiotic	Year Antibiotic Introduced	Year Resistance Identified	Notes
Penicillin	1943	1940	Penicillinase, a highly potent plasmid-encoded β-lactam ring hydrolyzer, was extracted from naturally resistant strains of S. aureus samples, collected before its clinical use
Methicillin	1960	1962	Before widespread use, resistance to Celbenin (Methicillin) was noted in clinical isolates obtained from skin lesions and anterior nares of hospitalized patients with no previous exposure to the drug.
Linezolid	2000	2001
Vancomycin	1972	2002	Resistance development evolved slowly over time with MIC creeps, therapeutic failures, VISA then VRSA
Ceftaroline	2010	2011