Table 2: Patient demographics and severity of illness before and after protocol implementation
| Parameters | All (n = 762) | Before "Per IDSA Guidelines" (n = 332) | Before "Off IDSA Guidelines" (n = 82) | After "Per Hospital Protocol" (n = 277) | After "Off Hospital Protocol" (n = 71) | p-value |
|---|---|---|---|---|---|---|
| Median Age (IQRa), yrs. | 60.5 (24) | 62 (27) | 58 (21) | 60 (22) | 60 (28) | 0.0720 |
| Race | ||||||
| White | 563 (73.9%) | 230 (69.3%) | 57 (69.5%) | 220 (79.7%) | 56 (78.9%) | |
| African American | 55 (7.2%) | 22 (6.6%) | 6 (7.3%) | 21 (7.6%) | 6 (8.5%) | |
| Hispanic | 94 (12.3%) | 59 (17.8%) | 13 (15.9%) | 15 (5.4%) | 7 (9.9%) | |
| Other | 50 (6.6%) | 21 (6.3%) | 6 (7.3%) | 21 (7.6%) | 2 (2.8%) | 0.0031 |
| Sex | ||||||
| Female | 422 (55.4%) | 187 (56.3%) | 47 (57.3%) | 145 (52.4%) | 43 (60.6%) | 0.5625 |
| Sex | ||||||
| Mild-moderate | 537 (70.5%) | 279 (84.0%) | 20 (24.4%) | 233 (84.1%) | 5 (7.0%) | |
| Severe 143 | (18.8%) | 40 (12.1%) | 21 (25.6%) | 35 (12.6%) | 47 (66.2%) | |
| Severe and complicated | 82 (10.8%) | 13 (3.9%) | 41 (50.0%) | 9 (3.3%) | 19 (26.8%) | < 0.0001 |
| NAP1b Strain | 206 (27.0%) | 92 (27.7%) | 27 (32.9%) | 72 (26.0%) | 15 (21.1%) | 0.4027 |
| Median SAPS IIc Score (IQR) | 25 (15) | 25 (14) | 26 (18) | 24 (13) | 30 (15) | 0.0018 |
| ICUd Admission | 360 (47.2%) | 144 (43.4%) | 54 (65.9%) | 114 (41.2%) | 48 (67.6%) | < 0.0001 |
aIQR: Interquartile Range; bNAP1: North American Pulsed Field Type 1; cSAPS II: Simplified Acute Physiology Score; dICU: Intensive Care Unit.