Table 4: Clinical characterisitics, CSF analysis and radiological features of patients with definite, probable and possible TBM.
| Definite TBM | Probable TBM | Possible TBM | p-value | |
| (n = 61) | n (%) | n (%) | n (%) | (< 0.05) |
| Clinical characteristic | ||||
| Age | 41 (27)* | 35 (26)* | 51.5 (31)* | 0.272 |
| Gender | 3/10 (30) | 7/11 (63.6) | 27/40 (67.5) | 0.092 |
| HIV infected | 2/10 (20) | 1/11 (9.1) | 4/40 (10) | 0.65 |
| Previous history of TB | 1/10 (10) | 2/11 (18.2) | 4/40 (10) | 0.743 |
| Duration of symptoms | 7 (13)* | 14 (14)* | 5 (7)* | 0.02 |
| Fever | 8/10 (80) | 8/11 (72.7) | 18/40 (45) | 0.063 |
| Fever (days) | 6.5 (11)* | 7 (14)* | 0 (4)* | 0.011 |
| Headache | 10/10 (100) | 9/11 (81.8) | 29/40 (72.5) | 0.158 |
| Photophobia | 5/10 (50) | 3/11 (27.3) | 19/40 (47.5) | 0.451 |
| Vomiting | 1/10 (10) | 1/11 (9.1) | 12/40 (30) | 0.195 |
| Weight loss | 3/10 (30) | 8/11 (72.7) | 14/40 (35) | 0.059 |
| Seizure | 3/10 (30) | 4/11 (36.4) | 15/40 (37.5) | 0.907 |
| Altered consciousness | 7/10 (70) | 7/11 (63.6) | 34/40 (85) | 0.236 |
| GCS Mild | 9/10 (90) | 7/11 (63.6) | 20/40 (50) | 0.239 |
| Moderate | 1/10 (10) | 3/11 (27.3) | 15/40 (37.5) | |
| Severe | 1/11 (9.1) | 5/40 (12.5) | ||
| BMRC Non specific symptom | 1/10 (10) | 3/11 (27.3) | 9/40 (22.5) | 0.482 |
| Drowsy/Focal signs | 9/10 (90) | 8/11 (72.7) | 27/40 (67.5) | |
| Deep stupor/Coma | 4/40 (10) | |||
| Cerebrospinal fluid analysis | ||||
| Opening pressure < 20 cm H2O | 3/10 (30) | 5/11 (45.5) | 18/40 (45) | 0.732 |
| > 20 cm H2O | 6/10 (60) | 5/11 (45.5) | 15/40 (37.5) | |
| Not measured | 1/10 (10) | 1/11 (9.9) | 7/40 (17.5) | |
| Presence of PMNL (cells × 106/L) | 3/10 (30) | 3/11 (27.3) | 11/40 (27.5) | 0.986 |
| Lymphocytes dominant (cells × 106/L) | 4/10 (40) | 3/11 (27.3) | 9/40 (22.5) | 0.529 |
| Protein concentration < 400 mg/dL | 1/10 (10) | 1/11 (9.1) | 5/40 (12.5) | 0.981 |
| 400-100 mg/dL | 2/10 (20) | 3/11 (27.3) | 11/40 (27.5) | |
| > 1000 mg/dL | 7/10 (70) | 7/11 (63.6) | 24/40 (60) | |
| Radiological features | ||||
| CT Brain (n = 60) | ||||
| Hydrocephalus | 4/10 (40) | 6/11 (54.5) | 16/39 (41) | 0.744 |
| Leptomeningeal enhancement | 4/10 (40) | 4/11 (36.4) | 4/39 (10.3) | 0.041 |
| Infarct | 4/10 (40) | 9/39 (23.1) | 0.086 | |
| Hyperdense | 1/11 (9.1) | 2/39 (5.1) | 0.633 | |
| Cerebral atrophy | 1/10 (10) | 2/11 (18.2) | 11/39 (28.2) | 0.506 |
| MRI Brain (n = 42) | ||||
| Hydrocephalus | 1/7 (14.3) | 3/6 (50) | 7/29 (24.1) | 0.311 |
| Leptomeningeal enhancement | 1/7 (14.3) | 5/6 (83.3) | 12/29 (41.4) | 0.041 |
| Infarct | 4/7 (57.1) | 2/6 (33.3) | 9/29 (31) | 0.429 |
| Tuberculoma | 4/7 (57.1) | 2/6 (33.3) | 7/29 (24.1) | 0.235 |
*Median (IQR); TB = Tuberculosis, GCS = Glasgow Coma Scale, PMNL = Polymorphonuclear Lymphocytes.