Table 3: Zinc
complexes with antimicrobial activity.
|
Compound* |
Better activity than ligand
against (MIC) |
Ref. |
|
[Zn(Cl)2(TMP)]∙H2Oa |
B. megaterium
(n.p.), B. cereus (n.p.), S. aureus (n.p.), E. coli (n.p.),
E. cloacae (n.p.), Pseudomona
sp. (n.p.) and B. melitensis
(n.p.) |
[43] |
|
[Zn(flmq)(phen)Cl]b |
E. coli (n.p.), B. cereus (n.p.)
and B. subtilis
(n.p.) |
[44] |
|
[Zn(erx)(phen)Cl]b |
S. aureus
(n.p.), B. cereus (n.p.) and B. subtilis (n.p.) |
|
|
[ZnL12(H2O)2]Cl2c |
E. coli (125
µg mL-1), S. aureus (125 µg mL-1),
L. monocytogenes (250 µg mL-1),
S. typhimurium (125 µg mL-1) and
P. aeruginosa (125 µg mL-1) |
[45] |
|
[ZnL22]
∙1,5H2Od |
E. coli (n.p.), S. aureus (n.p.), P. aeruginosa (n.p.), P. vulgaris (n.p.)
and B. subtilis (n.p.) |
[46] |
|
[Zn4(xylH-4)2(H2O)2]·NaCl·3H2Oe |
P. aeruginosa
(64 µg mL-1) and C. albicans
(n.p.) |
[47] |
|
[Zn(NMAPIMHMC)2]∙2H2Of |
S. aureus
(12.5 µg mL-1) and C. albicans (3.12 µg mL-1) |
[48] |
|
[Zn(TMPIMP)2]∙2H2Og |
S. aureus
(6.25 µg mL-1) and C. albicans (3.12 µg mL-1) |
|
|
[Zn2L3(SO4)2(H2O)4]∙2H2O, |
E. coli (n.p.), S. aureus (n.p.), A. niger (n.p.) and P. chrysogenum
(n.p.) |
[49] |
|
[Zn2L3(Cl)2(H2O)4]∙2H2Oh |
E. coli (n.p.), S. aureus (n.p.), A. niger (n.p.) and P. chrysogenum (n.p.) |
|
|
[Zn(NAL)2(N3)2]i |
K. pneumoniae
(n.p.), V. cholerae (n.p.), M. luteus (n.p.), S. aureus (n.p.), C. albicans (n.p.), C. tropicalis (n.p.) and
C. parapsilosis (n.p.) |
[50] |
|
[Zn(HL4)2]j |
E. coli (3.1
µg mL-1), S. aureus (2.5 µg mL-1),
E. faecalis (12.5 µg mL-1), S. mutans (6.25 µg mL-1), C. albicans (12.5 µg mL-1) and A. niger (6.25 µg mL-1) |
[51] |
|
Zn(L5)(OAc)·3H2Ok |
E. coli (244.3
µM), P. aeruginosa (244.3 µM), S. aureus (61 µM)
and B. subtilis (30.5 µM) |
[52] |
|
Zn(L5)2·2H2Ok |
E. coli (40.3
µM), P. aeruginosa (80.7 µM), S. aureus (10.0 µM) and B. subtilis
(10.0 µM) |
|
|
L6ZnCll |
E. coli (n.p.), P. aeruginosa (n.p.), B. subtilis (n.p.) and C. albicans
(n.p.) |
[53] |
|
[Zn(ATS)2]·H2Om |
S. typhi
(n.p.), P. aeruginosa (n.p.), S.
aureus (n.p.) and
B. subtilis (n.p.) |
[54] |
|
[ZnL72]n |
E. coli (50
µg mL-1), P. aeruginosa (100 µg
mL-1), S. aureus (25 µg mL-1),
B. subtilis (100 µg mL-1), C. albicans (100 µg mL-1), A. niger (50 µg mL-1), R. bataicola (100 µg mL-1) and R. stolonifer (100 µg mL-1) |
[55] |
|
[Zn2(Cip)2(bpdmed)2(pip)(H2O)2]·3H2O, |
E. coli (2.24
µM), S. marcescens (1.87 µM), P. aeruginosa (1.49 µM), S. aureus (0.75
µM) and B. subtilis (0.37 µM) |
[56] |
|
[Zn2(Cip)2(mtma)2(pip)(H2O)2]·3H2O, |
E. coli (1.92
µM), S. marcescens (2.69 µM), P. aeruginosa (1.92 µM), S. aureus (0.46
µM) and B. subtilis (0.31 µM) |
|
|
[Zn2(Cip)2(apq)2(pip)(H2O)2]·3H2O, |
E. coli (1.86
µM), S. marcescens (1.49 µM), P. aeruginosa (1.86 µM), S. aureus (0.75
µM) and B. subtilis (0.60 µM) |
|
|
[Zn2(Cip)2(bpeed)2(pip)(H2O)2]·3H2O, |
E. coli (2.15
µM), S. marcescens (2.15 µM), P. aeruginosa (1.79 µM), S. aureus (0.72
µM) and B. subtilis (0.36 µM) |
|
|
[Zn2(Cip)2(dcnd)2(pip)(H2O)2]·3H2O, |
E. coli (1.66
µM), S. marcescens (2.33 µM), P. aeruginosa (1.66 µM), S. aureus (0.67
µM) and B. subtilis (0.33 µM) |
|
|
[Zn2(Cip)2(dpeda)2(pip)(H2O)2]·3H2Oo |
E. coli (1.89 µM), S. marcescens
(1.89 µM), P. aeruginosa (1.26 µM), S. aureus (0.50
µM) and B. subtilis (0.50 µM) |
aTMP: trimethoprim
bphen: 1,10 phenantroline; oxo: oxolinate acid; flmq: flumequine; erx: enrofloxacinate;
cL1:
(E)-N-(furan-2-yl methylene) quinolin-8-amine
dL2:
ferulate: 4-hydroxy-3-methoxycinnamate
exyl: xylitol
f[NMAPIMHMC]
:7-Hydroxy-4-methyl-8-[(Z)-{[3-(methylamino)propyl]imino} methyl]-2H-chromen-2-one;
g[TMPIMP]:
2-[(E)-{[4-(1H-1,2,4- Triazol-1-ylmethyl)phenyl]imino}methyl]phenol
h(H2L3):
cyclodiphosph(V)azane
ligand
iNAL: N-phenyl-3-pyridinecarboxamide
jH2L4:
3-methoxysalicylaldehyde-2-aminobenzoylhydrazone
kOAc: acetate; [HL5]:
4-[(1,3-Diphenyl-1H-pyrazol-4-ylmethylene)-amino]-5-mercapto-1,2,4-triazole
l2-(N-3-formylchromone)iminothiazole: C15H14O3N2S:
HL6
mATS: 2-aminomethylthiophenyl-4-bromosalicylaldehyde
nSchiff base ligand (HL7) that was
synthesized by the condensation reaction between 2´-methyleacetoacetanilide and
2-amino-3-hydroxypyridine.
oCip: ciprofloxacin; pip: piperazine; bpmed: N,N´-bis-(phenyl)-1,2-dimethyl-ethane-1,2-diimine;
mtma:
4-methoxy-N-(thiophene-2-ylmethylene)aniline; apq:
3-amino-2-phenyl-3H-quinazolin-4-one; bpeed: N, N´-bis-(1-phenylethylidene)-ethane-1,2-diamine;
dcnd: N,
N´-dicyclohexylidene-naphthalene-1,8-diamine; dpeda:
N,N´-(1,2-diphenyl-ethane-1,2-diylidene)dianiline
*All the chemical names were in
accordance to bibliographic references
n.p.: MIC not published