Potential drug classes for therapy in PIH/placental dysfunction.

Table 1: Potential drug classes for therapy in PIH/placental dysfunction.

Drug Class	Potential mechanism	Class members	Pregnancy class
Nitrate donors	NO diffusion	Arginine, nitrates	B
PDE-5 blockers	Increased local NO production	Tadafil, sildenafil, numerous others	B except sildenafil C
Prostacyclin receptor agonists	Reduced vasoconstriction	Iloprost, beraprost	B iloprost beraprost unrated
Endothelin receptor blockers	Reduced vasoconstriction improved endothelial function	Sitaxentan, zilosentan numerous others	unrated