Table 2: The ten top variants from the single-variant analysis with minor allele frequency ≥ 0.5% in HyperGEN (N = 1,934).

Left ventricular traits SNP Chr Position Gene SNP function MAF Beta p-value
LAD rs45470697 5 149212624 PPARGC1B R330W 0.06 -0.04 5.6*10-7
LAD rs45519432 5 149212802 PPARGC1B S389Y 0.06 -0.04 5.7*10-7
E/A ratio rs8176919 16 3706697 DNASE1 G127R 0.06 0.08 4.7*10-6
E/A ratio rs41277210 1 216144049 USH2A R2292H 0.01 0.23 8.4*10-6
LVIDD rs35892492 20 62333521 ARFRP1 W105R 0.01 0.09 9.8*10-6
RWT rs769929111 1 55075452 FAM151A A416V 0.23 0.03 1.3*10-5
FS rs11555566 20 43255220 ADA K80R 0.07 1.54 1.4*10-5
FS rs36009281 5 70798541 BDP1 K722E 0.01 -3.58 1.7*10-5
E/A ratio rs1801270 6 36651971 CDKN1A S31R 0.27 0.04 2.1*10-5
E/A ratio rs9911502 17 73518203 TSEN54 K347N 0.2 0.04 3.0*10-5

*The models were adjusted for age, gender, center, body mass index and first 10 principal components. LAD: Left Atrial Dimension; E/A ratio: The ratio of left ventricular transmitral early velocity to late/atrial velocity; LVIDD: Left Ventricular Internal Dimension-Diastole; RWT: Relative Wall Thickness; FS: Fractional Shortening; LAD was square-rooted. E/A ratio, LVIDD, and RWT were natural log-transformed. MAF: Minor Allele Frequency.