Comparison of sFlt1 Mouse Model with Human Preeclampsia.

Table 1: Comparison of sFlt1 Mouse Model with Human Preeclampsia.

Feature	Mouse Model (sFlt1 Infusion)	Human Preeclampsia [21]
Maternal Hypertension	Elevated blood pressure, dose-dependent effects [1,23]	New-onset hypertension after 20 weeks of gestation, often severe in early-onset PE
Placental Dysfunction	Impaired placental vascularization, reduced labyrinthine differentiation [5,6]	Placental insufficiency, abnormal trophoblast invasion, and defective spiral artery remodeling
Fetal Growth Restriction	Asymmetric FGR, reduced fetal weight, increased brain-to-liver weight ratio [4,6]	FGR, often asymmetric, associated with placental insufficiency
Renal Damage	Glomerular endotheliosis, proteinuria, and renal dysfunction [1,2]	Glomerular endotheliosis, proteinuria, and renal dysfunction
Long-Term Risks in the mother	Increased sensitivity to hypertensive stimuli, aortic stiffness, and atherosclerotic inflammation [24]	Increased risk of cardiovascular diseases, hypertension, and stroke
Long-Term risks in the offspring	Increased blood pressure, insulin resistance and susceptibility to weight gain [13,14]	Increased risk for hypertension, stroke, diabetes, and cardiovascular disease.