Morning versus evening administration of once-daily oral cardiovascular drugs.

Table 1: Morning versus evening administration of once-daily oral cardiovascular drugs.

Medications	Optimal dosing time			References
Medications	Favoring evening dosing	Favoring morning dosing	Indifferent dosing time	References
Perindopril		√		[4]
Ramipril	√			[5]
Candesartan	√			[6,7]
Olmesartan			√	[8]
Olmesartan	√			[9,10]
Valsartan	√			[11]
Valsartan			√	[12,13]
Nebivolol	√			[14]
Nifedipine gastrointestinal therapeutic system	√			[15,16]
Amlodipine	√			[17]
Diuretics (thiazides, torasemide)^a	√			[19,20]
Valsartan/hydrochlorothiazide	√			[21]
Indapamide/losartan	√			[22]
Amlodipine/hydrochlorothiazide	√			[23]
Amlodipine/valsartan			√	[24,25]
Amlodipine/valsartan	√			[26]
Amlodipine/olmesartan			√	[27]
Amlodipine/olmesartan	√			[28]
Amlodipine/telmisartan	√			[29]
Amlodipine/fosinopril	√			[30]
Miscellaneous combination of antihypertensives	√ (Ingesting ≥ 1 antihypertensives)			[31-39]
Cardiovascular polypills (aspirin, simvastatin, lisinopril, hydrochlorothiazide)	√			[40]
Simvastatin immediate-release	√			[41]
Controlled-release simvastatin			√	[42,43]
Ezetimibe/simvastatin			√	[44]
Rivaroxaban	√			[45]
Aspirin	√			[46-48,51]
Aspirin			√	[49,50]

Notes: ^aMorning dosing could still be used for patients with troublesome night-time diuresis with poor quality sleep; √: Given.